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Xlr X-linked lymphocyte-regulated [ Mus musculus (house mouse) ]

Gene ID: 22441, updated on 8-Feb-2024

Summary

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Official Symbol
Xlrprovided by MGI
Official Full Name
X-linked lymphocyte-regulatedprovided by MGI
Primary source
MGI:MGI:98976
See related
Ensembl:ENSMUSG00000054626 AllianceGenome:MGI:98976
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to be involved in meiotic cell cycle and spermatogenesis, exchange of chromosomal proteins. Predicted to be located in lateral element. Predicted to be active in synaptonemal complex. Is expressed in germ cell of testis; gonad; and testis. Human ortholog(s) of this gene implicated in spermatogenic failure 4. Orthologous to human SYCP3 (synaptonemal complex protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in placenta adult (RPKM 1.3), liver E14 (RPKM 0.3) and 10 other tissues See more
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Genomic context

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Location:
X A5; X 30.06 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (52779084..52799673, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (53777118..53797716, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted pseudogene 6025 Neighboring gene zinc finger protein 36, C3H type-like 3 Neighboring gene 60S ribosomal protein L37 pseudogene Neighboring gene X-linked lymphocyte-regulated complex pseudogene Neighboring gene predicted gene, 38663

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Sequence analysis and expression of an X-linked, lymphocyte-regulated gene family (XLR). Siegel JN, et al. J Exp Med, 1987 Dec 1. PMID 3681192, Free PMC Article
  2. Ectopic expression of X-linked lymphocyte-regulated protein pM1 renders tumor cells resistant to antitumor immunity. Kang TH, et al. Cancer Res, 2010 Apr 15. PMID 20395201, Free PMC Article
  3. Sex-specific gene expression during meiotic prophase I: Xlr (X linked, lymphocyte regulated), not its male homologue Xmr (Xlr related, meiosis regulated), is expressed in mouse oocytes. Escalier D, et al. Biol Reprod, 2002 Nov. PMID 12390899
  4. The XLR sequence family: dispersion on the X and Y chromosomes of a large set of closely related sequences, most of which are pseudogenes. Garchon HJ, et al. Nucleic Acids Res, 1989 Dec 11. PMID 2602144, Free PMC Article
  5. The meiosis-specific Xmr gene product is homologous to the lymphocyte Xlr protein and is a component of the XY body. Calenda A, et al. EMBO J, 1994 Jan 1. PMID 8306953, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. X-linked lymphocyte-regulated protein pM1 (XMR), XLR, and SCP3 render tumor cells resistant to antitumor immunity
    Title: Ectopic expression of X-linked lymphocyte-regulated protein pM1 renders tumor cells resistant to antitumor immunity.
  2. Xlr (X linked, lymphocyte regulated) was expressed in oocytes throughout meiotic prophase I. These findings indicate a sex-specific expression of two closely related members of the Xlr gene family during meiotic prophase I.
    Title: Sex-specific gene expression during meiotic prophase I: Xlr (X linked, lymphocyte regulated), not its male homologue Xmr (Xlr related, meiosis regulated), is expressed in mouse oocytes.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in meiotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spermatid development IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in synaptonemal complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
X-linked lymphocyte-regulated protein PM1
Names
X-linked gene family of B-cell surface antigens
X-linked lymphocyte-regulated complex

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291747.2 → NP_001278676.1  X-linked lymphocyte-regulated protein PM1 isoform a

    See identical proteins and their annotated locations for NP_001278676.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4-8 all encode the same isoform (a).
    Source sequence(s)
    AL691513
    Consensus CDS
    CCDS30139.1
    UniProtKB/Swiss-Prot
    P05531
    UniProtKB/TrEMBL
    Q544L6
    Related
    ENSMUSP00000110458.2, ENSMUST00000114810.2
    Conserved Domains (1) summary
    pfam04803
    Location:61 → 192
    Cor1; Cor1/Xlr/Xmr conserved region

  2. NM_001291748.1 → NP_001278677.1  X-linked lymphocyte-regulated protein PM1 isoform b

    See identical proteins and their annotated locations for NP_001278677.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, the 3' UTR, and the 3' coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a. Variants 3, 9, and 10 all encode the same isoform (b).
    Source sequence(s)
    AK035025, AL691513
    Consensus CDS
    CCDS81127.1
    UniProtKB/TrEMBL
    Q8BS74
    Related
    ENSMUSP00000066162.2, ENSMUST00000067782.8
    Conserved Domains (1) summary
    pfam04803
    Location:63 → 162
    Cor1; Cor1/Xlr/Xmr conserved region

  3. NM_001426070.1 → NP_001412999.1  X-linked lymphocyte-regulated protein PM1 isoform a

    Status: VALIDATED

    Source sequence(s)
    AL691513
    UniProtKB/Swiss-Prot
    P05531
    UniProtKB/TrEMBL
    Q544L6

  4. NM_001426071.1 → NP_001413000.1  X-linked lymphocyte-regulated protein PM1 isoform a

    Status: VALIDATED

    Source sequence(s)
    AL691513
    UniProtKB/Swiss-Prot
    P05531
    UniProtKB/TrEMBL
    Q544L6

  5. NM_001426072.1 → NP_001413001.1  X-linked lymphocyte-regulated protein PM1 isoform a

    Status: VALIDATED

    Source sequence(s)
    AL691513
    UniProtKB/Swiss-Prot
    P05531
    UniProtKB/TrEMBL
    Q544L6

  6. NM_001426073.1 → NP_001413002.1  X-linked lymphocyte-regulated protein PM1 isoform a

    Status: VALIDATED

    Source sequence(s)
    AL691513
    UniProtKB/Swiss-Prot
    P05531
    UniProtKB/TrEMBL
    Q544L6

  7. NM_001426074.1 → NP_001413003.1  X-linked lymphocyte-regulated protein PM1 isoform a

    Status: VALIDATED

    Source sequence(s)
    AL691513
    UniProtKB/Swiss-Prot
    P05531
    UniProtKB/TrEMBL
    Q544L6

  8. NM_001426075.1 → NP_001413004.1  X-linked lymphocyte-regulated protein PM1 isoform b

    Status: VALIDATED

    Source sequence(s)
    AL691513
    UniProtKB/TrEMBL
    Q8BS74

  9. NM_001426076.1 → NP_001413005.1  X-linked lymphocyte-regulated protein PM1 isoform b

    Status: VALIDATED

    Source sequence(s)
    AL691513
    UniProtKB/TrEMBL
    Q8BS74

  10. NM_011725.5 → NP_035855.1  X-linked lymphocyte-regulated protein PM1 isoform a

    See identical proteins and their annotated locations for NP_035855.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1, 2, and 4-8 all encode the same isoform (a).
    Source sequence(s)
    AL691513
    Consensus CDS
    CCDS30139.1
    UniProtKB/Swiss-Prot
    P05531
    UniProtKB/TrEMBL
    Q544L6
    Related
    ENSMUSP00000068044.4, ENSMUST00000067763.10
    Conserved Domains (1) summary
    pfam04803
    Location:61 → 192
    Cor1; Cor1/Xlr/Xmr conserved region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    52779084..52799673 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P05531.1 GenPept UniProtKB/Swiss-Prot:P05531

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