Anks1 ankyrin repeat and SAM domain containing 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Anks1provided by MGI
Official Full Name: ankyrin repeat and SAM domain containing 1provided by MGI
Primary source: MGI:MGI:2446180
See related: Ensembl:ENSMUSG00000024219 AllianceGenome:MGI:2446180
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Anks1a; mKIAA0229
Summary: Enables ephrin receptor binding activity. Involved in ephrin receptor signaling pathway; neuron remodeling; and substrate-dependent cell migration. Acts upstream of or within negative regulation of ubiquitin-dependent protein catabolic process and regulation of ephrin receptor signaling pathway. Located in neuron projection. Is expressed in several structures, including genitourinary system; gut gland; nervous system; olfactory epithelium; and trachea. Orthologous to human ANKS1A (ankyrin repeat and sterile alpha motif domain containing 1A). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in lung adult (RPKM 18.8), thymus adult (RPKM 17.2) and 28 other tissues See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 17 A3.3; 17 14.6 cM

Exon count:: 31

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (28128273..28281753)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (27909304..28062779)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ANKS1A regulates LDL receptor-related protein 1 (LRP1)-mediated cerebrovascular clearance in brain endothelial cells.
Title: ANKS1A regulates LDL receptor-related protein 1 (LRP1)-mediated cerebrovascular clearance in brain endothelial cells.
Here, the authors systematically investigated the bindings of each SAM domain of Eph receptors to the SAM domains from SHIP2 and Odin, and uncover a highly specific SAM-SAM interaction-mediated cytoplasmic Eph-effector binding pattern.
Title: Specific Eph receptor-cytoplasmic effector signaling mediated by SAM-SAM domain interactions.
ependymal cells require Anks1a PTB adaptor for their proper development.
Title: Ependymal Cells Require Anks1a for Their Proper Development.
This study reveals a novel mechanism that regulates the loading of RTKs into COPII vesicles.
Title: Anks1a regulates COPII-mediated anterograde transport of receptor tyrosine kinases critical for tumorigenesis.
Findings strongly suggest that Odin plays a role in the differentiation of ependymal cells during early postnatal brain development.
Title: In Vivo Expression of the PTB-deleted Odin Mutant Results in Hydrocephalus.
Data suggest that Odin levels play a critical role in regulating the stability of EphA2 and A8 in response to ligand stimulation and by modulating the ubiquitination process.
Title: The SAM domains of Anks family proteins are critically involved in modulating the degradation of EphA receptors.
Odin expression in mice is not essential for any major developmental pathway; it could play a significant functional role to negatively regulate growth factor receptor signaling pathways. [Odin]
Title: Mouse embryonic fibroblasts derived from Odin deficient mice display a hyperproliiferative phenotype.

Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (2)
Targeted (3) 1 citation
Endonuclease-mediated (1)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

NoName (e-PCR)
- UniSTS:237603

D17Mit44 (e-PCR), detects polymorphism
- UniSTS:116644

12.MMHAP59FRD9.seq (e-PCR)
- UniSTS:123125

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ephrin receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables ephrin receptor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in ephrin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in ephrin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in neuron remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of ephrin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in substrate-dependent cell migration	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: ankyrin repeat and SAM domain-containing protein 1A

Names: Odin

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001286040.1 → NP_001272969.1 ankyrin repeat and SAM domain-containing protein 1A isoform 1

See identical proteins and their annotated locations for NP_001272969.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC126040, AC132460, AK147273

Consensus CDS

CCDS70777.1

UniProtKB/TrEMBL

Q3UHP6

Related

ENSMUSP00000025058.8, ENSMUST00000025058.15

Conserved Domains (7) summary

cd09499
Location:713 → 779

SAM_AIDA1AB-like_repeat1; SAM domain of AIDA1AB-like proteins, repeat 1

cd09500
Location:784 → 848

SAM_AIDA1AB-like_repeat2; SAM domain of AIDA1AB-like proteins, repeat 2

smart00454
Location:716 → 775

SAM; Sterile alpha motif

cd00204
Location:70 → 219

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd01274
Location:942 → 1087

PTB_Anks; Ankyrin repeat and sterile alpha motif (SAM) domain-containing (Anks) protein family Phosphotyrosine-binding (PTB) domain

pfam12796
Location:203 → 294

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:165 → 196

ANK; ANK repeat [structural motif]
NM_001286041.1 → NP_001272970.1 ankyrin repeat and SAM domain-containing protein 1A isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an in-frame exon the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

AC126040, AC132460

Consensus CDS

CCDS70778.1

UniProtKB/Swiss-Prot

P59672

Related

ENSMUSP00000085344.6, ENSMUST00000088027.7

Conserved Domains (7) summary

cd09499
Location:692 → 758

SAM_AIDA1AB-like_repeat1; SAM domain of AIDA1AB-like proteins, repeat 1

cd09500
Location:763 → 827

SAM_AIDA1AB-like_repeat2; SAM domain of AIDA1AB-like proteins, repeat 2

smart00454
Location:695 → 754

SAM; Sterile alpha motif

cd00204
Location:70 → 198

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd01274
Location:921 → 1066

PTB_Anks; Ankyrin repeat and sterile alpha motif (SAM) domain-containing (Anks) protein family Phosphotyrosine-binding (PTB) domain

pfam12796
Location:80 → 175

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:76 → 106

ANK; ANK repeat [structural motif]
NM_001374802.1 → NP_001361731.1 ankyrin repeat and SAM domain-containing protein 1A isoform 4

Status: VALIDATED

Source sequence(s)

AC126040, AC132460

Consensus CDS

CCDS89037.1

UniProtKB/TrEMBL

A0A3B2WAQ7

Related

ENSMUSP00000156466.2, ENSMUST00000233525.2

Conserved Domains (5) summary

cd09499
Location:692 → 758

SAM_AIDA1AB-like_repeat1; SAM domain of AIDA1AB-like proteins, repeat 1

cd09500
Location:763 → 827

SAM_AIDA1AB-like_repeat2; SAM domain of AIDA1AB-like proteins, repeat 2

PHA03095
Location:66 → 280

PHA03095; ankyrin-like protein; Provisional

cd01274
Location:921 → 1066

PTB_Anks; Ankyrin repeat and sterile alpha motif (SAM) domain-containing (Anks) protein family Phosphotyrosine-binding (PTB) domain

sd00045
Location:76 → 106

ANK; ANK repeat [structural motif]
NM_001425247.1 → NP_001412176.1 ankyrin repeat and SAM domain-containing protein 1A isoform 5

Status: VALIDATED

Source sequence(s)

AC126040, AC132460
NM_181413.4 → NP_852078.1 ankyrin repeat and SAM domain-containing protein 1A isoform 3

See identical proteins and their annotated locations for NP_852078.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) use an alternate structure at the 3' end which results in a frameshift compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus compared to isoform 2.

Source sequence(s)

AC126040, AC132460

Consensus CDS

CCDS37525.1

UniProtKB/Swiss-Prot

P59672, Q6ZQG0

Related

ENSMUSP00000110491.2, ENSMUST00000114842.9

Conserved Domains (7) summary

cd09499
Location:713 → 779

SAM_AIDA1AB-like_repeat1; SAM domain of AIDA1AB-like proteins, repeat 1

cd09500
Location:784 → 848

SAM_AIDA1AB-like_repeat2; SAM domain of AIDA1AB-like proteins, repeat 2

smart00454
Location:716 → 775

SAM; Sterile alpha motif

cd00204
Location:70 → 219

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd01274
Location:942 → 1087

PTB_Anks; Ankyrin repeat and sterile alpha motif (SAM) domain-containing (Anks) protein family Phosphotyrosine-binding (PTB) domain

pfam12796
Location:203 → 294

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:165 → 196

ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

28128273..28281753

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006524087.3 → XP_006524150.1 ankyrin repeat and SAM domain-containing protein 1A isoform X1

See identical proteins and their annotated locations for XP_006524150.1

Conserved Domains (6) summary

cd09499
Location:713 → 779

SAM_AIDA1AB-like_repeat1; SAM domain of AIDA1AB-like proteins, repeat 1

cd09500
Location:784 → 848

SAM_AIDA1AB-like_repeat2; SAM domain of AIDA1AB-like proteins, repeat 2

PHA03095
Location:66 → 301

PHA03095; ankyrin-like protein; Provisional

cd01274
Location:942 → 1087

PTB_Anks; Ankyrin repeat and sterile alpha motif (SAM) domain-containing (Anks) protein family Phosphotyrosine-binding (PTB) domain

sd00045
Location:165 → 196

ANK; ANK repeat [structural motif]

pfam12796
Location:203 → 294

Ank_2; Ankyrin repeats (3 copies)
XM_006524088.3 → XP_006524151.1 ankyrin repeat and SAM domain-containing protein 1A isoform X2

See identical proteins and their annotated locations for XP_006524151.1

Conserved Domains (6) summary

cd09499
Location:713 → 779

SAM_AIDA1AB-like_repeat1; SAM domain of AIDA1AB-like proteins, repeat 1

cd09500
Location:784 → 848

SAM_AIDA1AB-like_repeat2; SAM domain of AIDA1AB-like proteins, repeat 2

PHA03095
Location:66 → 301

PHA03095; ankyrin-like protein; Provisional

cd01274
Location:942 → 1087

PTB_Anks; Ankyrin repeat and sterile alpha motif (SAM) domain-containing (Anks) protein family Phosphotyrosine-binding (PTB) domain

sd00045
Location:165 → 196

ANK; ANK repeat [structural motif]

pfam12796
Location:203 → 294

Ank_2; Ankyrin repeats (3 copies)
XM_030249683.2 → XP_030105543.1 ankyrin repeat and SAM domain-containing protein 1A isoform X3

Conserved Domains (6) summary

cd09499
Location:674 → 740

SAM_AIDA1AB-like_repeat1; SAM domain of AIDA1AB-like proteins, repeat 1

cd09500
Location:745 → 809

SAM_AIDA1AB-like_repeat2; SAM domain of AIDA1AB-like proteins, repeat 2

PHA03095
Location:27 → 262

PHA03095; ankyrin-like protein; Provisional

cd01274
Location:903 → 1048

PTB_Anks; Ankyrin repeat and sterile alpha motif (SAM) domain-containing (Anks) protein family Phosphotyrosine-binding (PTB) domain

sd00045
Location:126 → 157

ANK; ANK repeat [structural motif]

pfam12796
Location:164 → 255

Ank_2; Ankyrin repeats (3 copies)
XM_030249682.1 → XP_030105542.1 ankyrin repeat and SAM domain-containing protein 1A isoform X3

Conserved Domains (6) summary

cd09499
Location:674 → 740

SAM_AIDA1AB-like_repeat1; SAM domain of AIDA1AB-like proteins, repeat 1

cd09500
Location:745 → 809

SAM_AIDA1AB-like_repeat2; SAM domain of AIDA1AB-like proteins, repeat 2

PHA03095
Location:27 → 262

PHA03095; ankyrin-like protein; Provisional

cd01274
Location:903 → 1048

PTB_Anks; Ankyrin repeat and sterile alpha motif (SAM) domain-containing (Anks) protein family Phosphotyrosine-binding (PTB) domain

sd00045
Location:126 → 157

ANK; ANK repeat [structural motif]

pfam12796
Location:164 → 255

Ank_2; Ankyrin repeats (3 copies)
XM_030249685.1 → XP_030105545.1 ankyrin repeat and SAM domain-containing protein 1A isoform X5

Conserved Domains (6) summary

cd09499
Location:651 → 717

SAM_AIDA1AB-like_repeat1; SAM domain of AIDA1AB-like proteins, repeat 1

cd09500
Location:722 → 786

SAM_AIDA1AB-like_repeat2; SAM domain of AIDA1AB-like proteins, repeat 2

PHA03095
Location:4 → 239

PHA03095; ankyrin-like protein; Provisional

cd01274
Location:880 → 1025

PTB_Anks; Ankyrin repeat and sterile alpha motif (SAM) domain-containing (Anks) protein family Phosphotyrosine-binding (PTB) domain

sd00045
Location:103 → 134

ANK; ANK repeat [structural motif]

pfam12796
Location:141 → 232

Ank_2; Ankyrin repeats (3 copies)
XM_006524089.5 → XP_006524152.1 ankyrin repeat and SAM domain-containing protein 1A isoform X3

See identical proteins and their annotated locations for XP_006524152.1

Conserved Domains (6) summary

cd09499
Location:674 → 740

SAM_AIDA1AB-like_repeat1; SAM domain of AIDA1AB-like proteins, repeat 1

cd09500
Location:745 → 809

SAM_AIDA1AB-like_repeat2; SAM domain of AIDA1AB-like proteins, repeat 2

PHA03095
Location:27 → 262

PHA03095; ankyrin-like protein; Provisional

cd01274
Location:903 → 1048

PTB_Anks; Ankyrin repeat and sterile alpha motif (SAM) domain-containing (Anks) protein family Phosphotyrosine-binding (PTB) domain

sd00045
Location:126 → 157

ANK; ANK repeat [structural motif]

pfam12796
Location:164 → 255

Ank_2; Ankyrin repeats (3 copies)
XM_030249686.2 → XP_030105546.1 ankyrin repeat and SAM domain-containing protein 1A isoform X8

UniProtKB/TrEMBL

A0A3B2W7H4, Q3TE53

Conserved Domains (3) summary

cd09499
Location:156 → 222

SAM_AIDA1AB-like_repeat1; SAM domain of AIDA1AB-like proteins, repeat 1

cd09500
Location:227 → 291

SAM_AIDA1AB-like_repeat2; SAM domain of AIDA1AB-like proteins, repeat 2

cd01274
Location:385 → 530

PTB_Anks; Ankyrin repeat and sterile alpha motif (SAM) domain-containing (Anks) protein family Phosphotyrosine-binding (PTB) domain
XM_036160515.1 → XP_036016408.1 ankyrin repeat and SAM domain-containing protein 1A isoform X6

Conserved Domains (3) summary

cd09499
Location:156 → 222

SAM_AIDA1AB-like_repeat1; SAM domain of AIDA1AB-like proteins, repeat 1

cd09500
Location:227 → 291

SAM_AIDA1AB-like_repeat2; SAM domain of AIDA1AB-like proteins, repeat 2

cd01274
Location:385 → 530

PTB_Anks; Ankyrin repeat and sterile alpha motif (SAM) domain-containing (Anks) protein family Phosphotyrosine-binding (PTB) domain
XM_036160516.1 → XP_036016409.1 ankyrin repeat and SAM domain-containing protein 1A isoform X7

UniProtKB/TrEMBL

Q3TE53

Conserved Domains (3) summary

cd09499
Location:156 → 222

SAM_AIDA1AB-like_repeat1; SAM domain of AIDA1AB-like proteins, repeat 1

cd09500
Location:227 → 291

SAM_AIDA1AB-like_repeat2; SAM domain of AIDA1AB-like proteins, repeat 2

cd01274
Location:385 → 530

PTB_Anks; Ankyrin repeat and sterile alpha motif (SAM) domain-containing (Anks) protein family Phosphotyrosine-binding (PTB) domain
XM_006524091.4 → XP_006524154.1 ankyrin repeat and SAM domain-containing protein 1A isoform X8

See identical proteins and their annotated locations for XP_006524154.1

UniProtKB/TrEMBL

A0A3B2W7H4, Q3TE53

Related

ENSMUSP00000156518.2, ENSMUST00000139173.3

Conserved Domains (3) summary

cd09499
Location:156 → 222

SAM_AIDA1AB-like_repeat1; SAM domain of AIDA1AB-like proteins, repeat 1

cd09500
Location:227 → 291

SAM_AIDA1AB-like_repeat2; SAM domain of AIDA1AB-like proteins, repeat 2

cd01274
Location:385 → 530

PTB_Anks; Ankyrin repeat and sterile alpha motif (SAM) domain-containing (Anks) protein family Phosphotyrosine-binding (PTB) domain
XM_036160517.1 → XP_036016410.1 ankyrin repeat and SAM domain-containing protein 1A isoform X7

UniProtKB/TrEMBL

Q3TE53

Conserved Domains (3) summary

cd09499
Location:156 → 222

SAM_AIDA1AB-like_repeat1; SAM domain of AIDA1AB-like proteins, repeat 1

cd09500
Location:227 → 291

SAM_AIDA1AB-like_repeat2; SAM domain of AIDA1AB-like proteins, repeat 2

cd01274
Location:385 → 530

PTB_Anks; Ankyrin repeat and sterile alpha motif (SAM) domain-containing (Anks) protein family Phosphotyrosine-binding (PTB) domain
XM_030249687.2 → XP_030105547.1 ankyrin repeat and SAM domain-containing protein 1A isoform X10

UniProtKB/TrEMBL

A0A3B2W4H6

Conserved Domains (3) summary

cd09500
Location:36 → 100

SAM_AIDA1AB-like_repeat2; SAM domain of AIDA1AB-like proteins, repeat 2

cd01274
Location:194 → 339

PTB_Anks; Ankyrin repeat and sterile alpha motif (SAM) domain-containing (Anks) protein family Phosphotyrosine-binding (PTB) domain

cl15755
Location:1 → 31

SAM_superfamily; SAM (Sterile alpha motif )
XM_036160518.1 → XP_036016411.1 ankyrin repeat and SAM domain-containing protein 1A isoform X9

UniProtKB/TrEMBL

A0A3B2W4H6

Related

ENSMUSP00000156946.2, ENSMUST00000232872.2

Conserved Domains (3) summary

cd09499
Location:17 → 83

SAM_AIDA1AB-like_repeat1; SAM domain of AIDA1AB-like proteins, repeat 1

cd09500
Location:88 → 152

SAM_AIDA1AB-like_repeat2; SAM domain of AIDA1AB-like proteins, repeat 2

cd01274
Location:246 → 391

PTB_Anks; Ankyrin repeat and sterile alpha motif (SAM) domain-containing (Anks) protein family Phosphotyrosine-binding (PTB) domain