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Enpp4 ectonucleotide pyrophosphatase/phosphodiesterase 4 [ Mus musculus (house mouse) ]

Gene ID: 224794, updated on 5-Mar-2024

Summary

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Official Symbol
Enpp4provided by MGI
Official Full Name
ectonucleotide pyrophosphatase/phosphodiesterase 4provided by MGI
Primary source
MGI:MGI:2682634
See related
Ensembl:ENSMUSG00000023961 AllianceGenome:MGI:2682634
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm90; E-NPP 4; 4933413N07Rik
Summary
Predicted to enable bis(5'-adenosyl)-triphosphatase activity. Predicted to be involved in positive regulation of blood coagulation and purine ribonucleoside catabolic process. Predicted to act upstream of or within blood coagulation. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Is expressed in bladder; limb; limb musculature; pancreas epithelium; and thymus primordium. Orthologous to human ENPP4 (ectonucleotide pyrophosphatase/phosphodiesterase 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 7.4), genital fat pad adult (RPKM 5.6) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 B3; 17 20.34 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (44407198..44416725, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (44096307..44105809, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34857 Neighboring gene ectonucleotide pyrophosphatase/phosphodiesterase 5 Neighboring gene predicted gene, 34917 Neighboring gene chloride intracellular channel 5 Neighboring gene STARR-seq mESC enhancer starr_42608 Neighboring gene STARR-positive B cell enhancer ABC_E5611 Neighboring gene STARR-seq mESC enhancer starr_42609 Neighboring gene STARR-seq mESC enhancer starr_42610 Neighboring gene STARR-seq mESC enhancer starr_42611 Neighboring gene runt related transcription factor 2 Neighboring gene runt related transcription factor 2, opposite strand 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Homology modeling and docking studies of ENPP4: a BCG activated tumoricidal macrophage protein. Yan D, et al. Lipids Health Dis, 2016 Jan 28. PMID 26823374, Free PMC Article
  2. Identification of candidate lung cancer susceptibility genes in mouse using oligonucleotide arrays. Lemon WJ, et al. J Med Genet, 2002 Sep. PMID 12205107, Free PMC Article
  3. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
  4. Identification of transcripts with enriched expression in the developing and adult pancreas. Hoffman BG, et al. Genome Biol, 2008. PMID 18554416, Free PMC Article
  5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC29265

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables bis(5'-adenosyl)-triphosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within blood coagulation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within hemostasis IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of blood coagulation ISO
Inferred from Sequence Orthology
more info
  
involved_in purine ribonucleoside catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
bis(5'-adenosyl)-triphosphatase enpp4
Names
AP3A hydrolase
AP3Aase
E-NPP4
NPP-4
ectonucleotide pyrophosphatase/phosphodiesterase family member 4
NP_001344925.1
NP_001344926.1
NP_950181.2
XP_006524196.1
XP_017172927.1
XP_036016444.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357996.1 → NP_001344925.1  bis(5'-adenosyl)-triphosphatase enpp4 precursor

    Status: VALIDATED

    Source sequence(s)
    AI854294, CT030230
    Consensus CDS
    CCDS28803.1
    UniProtKB/Swiss-Prot
    Q3TZS2, Q69ZX0, Q8BTJ4, Q8K1L3
    Related
    ENSMUSP00000114429.2, ENSMUST00000143137.2
    Conserved Domains (1) summary
    cd16018
    Location:29 → 382
    Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin

  2. NM_001357997.1 → NP_001344926.1  bis(5'-adenosyl)-triphosphatase enpp4 precursor

    Status: VALIDATED

    Source sequence(s)
    AI854294, CT030230
    Consensus CDS
    CCDS28803.1
    UniProtKB/Swiss-Prot
    Q3TZS2, Q69ZX0, Q8BTJ4, Q8K1L3
    Conserved Domains (1) summary
    cd16018
    Location:29 → 382
    Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin

  3. NM_199016.2 → NP_950181.2  bis(5'-adenosyl)-triphosphatase enpp4 precursor

    See identical proteins and their annotated locations for NP_950181.2

    Status: VALIDATED

    Source sequence(s)
    CAAA01049488, CB723093, CJ182752, CO044941
    Consensus CDS
    CCDS28803.1
    UniProtKB/Swiss-Prot
    Q3TZS2, Q69ZX0, Q8BTJ4, Q8K1L3
    Related
    ENSMUSP00000024757.8, ENSMUST00000024757.14
    Conserved Domains (1) summary
    cd16018
    Location:29 → 382
    Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    44407198..44416725 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160551.1 → XP_036016444.1  bis(5'-adenosyl)-triphosphatase enpp4 isoform X3

    Conserved Domains (1) summary
    cd16018
    Location:29 → 381
    Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin

  2. XM_017317438.1 → XP_017172927.1  bis(5'-adenosyl)-triphosphatase enpp4 isoform X2

    Conserved Domains (1) summary
    cd16018
    Location:43 → 395
    Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin

  3. XM_006524133.1 → XP_006524196.1  bis(5'-adenosyl)-triphosphatase enpp4 isoform X1

    Conserved Domains (1) summary
    cd16018
    Location:43 → 396
    Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BTJ4.1 GenPept UniProtKB/Swiss-Prot:Q8BTJ4

Gene LinkOut

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