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Treml4 triggering receptor expressed on myeloid cells-like 4 [ Mus musculus (house mouse) ]

Gene ID: 224840, updated on 23-Jun-2021

Summary

Official Symbol
Treml4provided by MGI
Official Full Name
triggering receptor expressed on myeloid cells-like 4provided by MGI
Primary source
MGI:MGI:1923239
See related
Ensembl:ENSMUSG00000051682
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TLT4; IDCP1; TLT-4; Treml3; BB137214; 5031403H21Rik
Expression
Biased expression in spleen adult (RPKM 17.3), lung adult (RPKM 2.7) and 5 other tissues See more
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Genomic context

See Treml4 in Genome Data Viewer
Location:
17; 17 C
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (48571229..48582635)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (48264200..48275607)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (48403661..48414724)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52308 Neighboring gene triggering receptor expressed on myeloid cells 1 Neighboring gene Ewing sarcoma breakpoint region 1 pseudogene Neighboring gene predicted gene, 52307 Neighboring gene triggering receptor expressed on myeloid cells 3 Neighboring gene triggering receptor expressed on myeloid cells-like 2 Neighboring gene RIKEN cDNA B430306N03 gene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with lysosomal membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
trem-like transcript 4 protein
Names
IG-like domain containing protein IDCP1c
triggering receptor expressed on myeloid cells-like 3
triggering receptor expressed on myeloid cells-like 3b
triggering receptor expressed on myeloid cells-like protein 3
triggering receptor expressed on myeloid cells-like protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033922.2NP_001029094.1  trem-like transcript 4 protein isoform 1 precursor

    See identical proteins and their annotated locations for NP_001029094.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) uses alternate in-frame splice junctions at the 5' ends of two exons compared to variant 3. The resulting isoform (1) has the same N- and C-termini but is shorter compared to isoform 3.
    Source sequence(s)
    AC241601, AK077228, DQ186654
    Consensus CDS
    CCDS50141.1
    UniProtKB/Swiss-Prot
    Q3LRV9
    Related
    ENSMUSP00000119177.2, ENSMUST00000125426.8
    Conserved Domains (1) summary
    cd05716
    Location:35124
    Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
  2. NM_001163795.1NP_001157267.1  trem-like transcript 4 protein isoform 3 precursor

    See identical proteins and their annotated locations for NP_001157267.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
    Source sequence(s)
    AC241601, AK077228, AY465532
    Consensus CDS
    CCDS50139.1
    UniProtKB/TrEMBL
    D3YYN5
    Related
    ENSMUSP00000118772.2, ENSMUST00000154335.8
    Conserved Domains (1) summary
    cd05716
    Location:39128
    Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
  3. NM_001163796.1NP_001157268.1  trem-like transcript 4 protein isoform 4 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 3. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 3.
    Source sequence(s)
    AC241601, AK077228, AY465532
    Consensus CDS
    CCDS50140.1
    UniProtKB/TrEMBL
    D3YY88
    Related
    ENSMUSP00000120550.2, ENSMUST00000136272.8
    Conserved Domains (1) summary
    cd05716
    Location:39128
    Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
  4. NM_172623.2NP_766211.2  trem-like transcript 4 protein isoform 2 precursor

    See identical proteins and their annotated locations for NP_766211.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 3. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 3.
    Source sequence(s)
    AC241601, AK077228, BC117091
    Consensus CDS
    CCDS28862.1
    UniProtKB/Swiss-Prot
    Q3LRV9
    Related
    ENSMUSP00000054121.8, ENSMUST00000059873.14
    Conserved Domains (1) summary
    cd05716
    Location:39128
    Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    48571229..48582635
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006524147.5XP_006524210.1  trem-like transcript 4 protein isoform X1

    Conserved Domains (1) summary
    cd05716
    Location:35124
    Ig_pIgR_like; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar domains
  2. XM_006524148.4XP_006524211.1  trem-like transcript 4 protein isoform X2

    Conserved Domains (1) summary
    cd05716
    Location:39128
    Ig_pIgR_like; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar domains
  3. XM_006524149.4XP_006524212.1  trem-like transcript 4 protein isoform X3

    UniProtKB/Swiss-Prot
    Q3LRV9
    Related
    ENSMUSP00000115290.2, ENSMUST00000153420.2
    Conserved Domains (1) summary
    cd05716
    Location:39128
    Ig_pIgR_like; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar domains
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