Treml4 triggering receptor expressed on myeloid cells-like 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Treml4provided by MGI
Official Full Name: triggering receptor expressed on myeloid cells-like 4provided by MGI
Primary source: MGI:MGI:1923239
See related: Ensembl:ENSMUSG00000051682 AllianceGenome:MGI:1923239
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TLT4; IDCP1; TLT-4; Treml3; 5031403H21Rik
Summary: Predicted to enable signaling receptor activity. Involved in positive regulation of defense response to virus by host; positive regulation of toll-like receptor signaling pathway; and protein localization. Acts upstream of or within T cell antigen processing and presentation and phagocytosis, engulfment. Located in endoplasmic reticulum. Colocalizes with endosome membrane and lysosomal membrane. Orthologous to human TREML4 (triggering receptor expressed on myeloid cells like 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in spleen adult (RPKM 17.3), lung adult (RPKM 2.7) and 5 other tissues See more
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Genomic context

Location:: 17 C; 17 23.99 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (48571229..48582635)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (48264200..48275607)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TREML4 Promotes Inflammatory Programs in Human and Murine Macrophages and Alters Atherosclerosis Lesion Composition in the Apolipoprotein E Deficient Mouse.
Title: TREML4 Promotes Inflammatory Programs in Human and Murine Macrophages and Alters Atherosclerosis Lesion Composition in the Apolipoprotein E Deficient Mouse.
positive regulator of TLR7 signaling that controls antiviral immunity and the development of autoimmunity
Title: The receptor TREML4 amplifies TLR7-mediated signaling during antiviral responses and autoimmunity.
Treml4 participates in Ag presentation in vivo
Title: Treml4, an Ig superfamily member, mediates presentation of several antigens to T cells in vivo, including protective immunity to HER2 protein.
Treml4 associates with adaptor molecule DNAX activation protein 12 kDa (DAP12) and serves as a marker for select groups of both dendritic cells and macrophages.
Title: A new triggering receptor expressed on myeloid cells (Trem) family member, Trem-like 4, binds to dead cells and is a DNAX activation protein 12-linked marker for subsets of mouse macrophages and dendritic cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (2)

General gene information

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Markers

NoName (e-PCR)
- UniSTS:492744

BB137214 (e-PCR)
- UniSTS:186105

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within T cell antigen processing and presentation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within defense response to virus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within innate immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phagocytosis, engulfment	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of defense response to virus by host	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of toll-like receptor 13 signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of toll-like receptor 7 signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of toll-like receptor 7 signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of toll-like receptor 7 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of toll-like receptor 9 signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with endosome membrane	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with lysosomal membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: trem-like transcript 4 protein

Names: IG-like domain containing protein IDCP1c; triggering receptor expressed on myeloid cells-like 3; triggering receptor expressed on myeloid cells-like 3b; triggering receptor expressed on myeloid cells-like protein 3; triggering receptor expressed on myeloid cells-like protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033922.2 → NP_001029094.1 trem-like transcript 4 protein isoform 1 precursor

See identical proteins and their annotated locations for NP_001029094.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) uses alternate in-frame splice junctions at the 5' ends of two exons compared to variant 3. The resulting isoform (1) has the same N- and C-termini but is shorter compared to isoform 3.

Source sequence(s)

AC241601, AK077228, DQ186654

Consensus CDS

CCDS50141.1

UniProtKB/Swiss-Prot

Q3LRV9

Related

ENSMUSP00000119177.2, ENSMUST00000125426.8

Conserved Domains (1) summary

cd05716
Location:35 → 124

Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
NM_001163795.1 → NP_001157267.1 trem-like transcript 4 protein isoform 3 precursor

See identical proteins and their annotated locations for NP_001157267.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).

Source sequence(s)

AC241601, AK077228, AY465532

Consensus CDS

CCDS50139.1

UniProtKB/TrEMBL

D3YYN5

Related

ENSMUSP00000118772.2, ENSMUST00000154335.8

Conserved Domains (1) summary

cd05716
Location:39 → 128

Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
NM_001163796.1 → NP_001157268.1 trem-like transcript 4 protein isoform 4 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (4) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 3. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 3.

Source sequence(s)

AC241601, AK077228, AY465532

Consensus CDS

CCDS50140.1

UniProtKB/TrEMBL

D3YY88

Related

ENSMUSP00000120550.2, ENSMUST00000136272.8

Conserved Domains (1) summary

cd05716
Location:39 → 128

Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
NM_172623.2 → NP_766211.2 trem-like transcript 4 protein isoform 2 precursor

See identical proteins and their annotated locations for NP_766211.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 3. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 3.

Source sequence(s)

AC241601, AK077228, BC117091

Consensus CDS

CCDS28862.1

UniProtKB/Swiss-Prot

A6XA78, E9Q825, Q3LRV9, Q3LRW0

Related

ENSMUSP00000054121.8, ENSMUST00000059873.14

Conserved Domains (1) summary

cd05716
Location:39 → 128

Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

48571229..48582635

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006524147.5 → XP_006524210.1 trem-like transcript 4 protein isoform X1

Conserved Domains (1) summary

cd05716
Location:35 → 124

Ig_pIgR_like; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar domains
XM_006524148.4 → XP_006524211.1 trem-like transcript 4 protein isoform X2

UniProtKB/TrEMBL

A0A0R4J1R6

Conserved Domains (1) summary

cd05716
Location:39 → 128

Ig_pIgR_like; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar domains
XM_006524149.4 → XP_006524212.1 trem-like transcript 4 protein isoform X3

UniProtKB/TrEMBL

A0A0R4J1R6

Related

ENSMUSP00000115290.2, ENSMUST00000153420.2

Conserved Domains (1) summary

cd05716
Location:39 → 128

Ig_pIgR_like; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar domains