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Ttc7 tetratricopeptide repeat domain 7 [ Mus musculus (house mouse) ]

Gene ID: 225049, updated on 23-Jun-2021

Summary

Official Symbol
Ttc7provided by MGI
Official Full Name
tetratricopeptide repeat domain 7provided by MGI
Primary source
MGI:MGI:1920999
See related
Ensembl:ENSMUSG00000036918
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
f; he; fsn; hea; Ttc7a; 1110035E02Rik; 1700007L07Rik
Expression
Broad expression in duodenum adult (RPKM 23.6), spleen adult (RPKM 20.7) and 24 other tissues See more
Orthologs
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Genomic context

See Ttc7 in Genome Data Viewer
Location:
17; 17 E4
Exon count:
24
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (87590245..87689198)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (87282808..87381770)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (87682226..87781110)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4833418N02 gene Neighboring gene multiple coagulation factor deficiency 2 Neighboring gene predicted gene, 52284 Neighboring gene uncharacterized LOC102632541 Neighboring gene sperm tail PG rich repeat containing 4 Neighboring gene calmodulin 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
flaky skin
GeneReviews: Not available
hereditary erythroblastic anemia
GeneReviews: Not available
Homozygotes for a spontaneous mutation exhibit reduced growth, sparse hair, thickened, scaly skin, increased numbers of splenic B cells, macrophages, and erythroid cells, elevated IgE, glomerulonephritis, and forestomach papillomas.[MGI]
GeneReviews: Not available

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Spontaneous (3)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
tetratricopeptide repeat protein 7A
Names
TPR repeat protein 7A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028639.3NP_082915.1  tetratricopeptide repeat protein 7A

    See identical proteins and their annotated locations for NP_082915.1

    Status: VALIDATED

    Source sequence(s)
    AK040578, AK080284, AV315613
    Consensus CDS
    CCDS29016.1
    UniProtKB/Swiss-Prot
    Q8BGB2
    Related
    ENSMUSP00000040771.6, ENSMUST00000041110.12
    Conserved Domains (3) summary
    sd00006
    Location:747773
    TPR; TPR repeat [structural motif]
    pfam13414
    Location:712776
    TPR_11; TPR repeat
    pfam13432
    Location:749808
    TPR_16; Tetratricopeptide repeat

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    87590245..87689198
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160578.1XP_036016471.1  tetratricopeptide repeat protein 7A isoform X2

    Conserved Domains (3) summary
    COG3118
    Location:353443
    YbbN; Negative regulator of GroEL, contains thioredoxin-like and TPR-like domains [Posttranslational modification, protein turnover, chaperones]
    TIGR00990
    Location:492730
    3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
    sd00006
    Location:634660
    TPR; TPR repeat [structural motif]
  2. XM_006524201.5XP_006524264.1  tetratricopeptide repeat protein 7A isoform X1

    Conserved Domains (2) summary
    TIGR00990
    Location:646884
    3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
    sd00006
    Location:788814
    TPR; TPR repeat [structural motif]
  3. XM_006524202.5XP_006524265.1  tetratricopeptide repeat protein 7A isoform X3

    Conserved Domains (3) summary
    COG3118
    Location:507597
    YbbN; Negative regulator of GroEL, contains thioredoxin-like and TPR-like domains [Posttranslational modification, protein turnover, chaperones]
    sd00008
    Location:490525
    TPR_YbbN; TPR repeat [structural motif]
    sd00006
    Location:529568
    TPR; TPR repeat [structural motif]
  4. XM_017317451.1XP_017172940.1  tetratricopeptide repeat protein 7A isoform X4

    Conserved Domains (2) summary
    TIGR00990
    Location:350588
    3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
    sd00006
    Location:492518
    TPR; TPR repeat [structural motif]
  5. XM_011246415.3XP_011244717.1  tetratricopeptide repeat protein 7A isoform X5

    Conserved Domains (2) summary
    TIGR00990
    Location:207445
    3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
    sd00006
    Location:349375
    TPR; TPR repeat [structural motif]
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