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Svil supervillin [ Mus musculus (house mouse) ]

Gene ID: 225115, updated on 3-Apr-2024

Summary

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Official Symbol
Svilprovided by MGI
Official Full Name
supervillinprovided by MGI
Primary source
MGI:MGI:2147319
See related
Ensembl:ENSMUSG00000024236 AllianceGenome:MGI:2147319
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
B430302E16Rik
Summary
Predicted to enable actin filament binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in several processes, including actin filament severing; actin polymerization or depolymerization; and barbed-end actin filament capping. Predicted to be located in several cellular components, including costamere; cytosol; and nucleus. Predicted to be active in actin cytoskeleton and cytoplasm. Is expressed in several structures, including exoccipital bone; gut; meninges; pharyngo-tympanic tube; and skin. Human ortholog(s) of this gene implicated in myofibrillar myopathy 10. Orthologous to human SVIL (supervillin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bladder adult (RPKM 33.3), heart adult (RPKM 16.5) and 20 other tissues See more
Orthologs
human all
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Genomic context

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See Svil in Genome Data Viewer
Location:
18 A1; 18 3.02 cM
Exon count:
44
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (4920497..5119290)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (4920467..5119293)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene 10556 Neighboring gene predicted gene, 34269 Neighboring gene predicted gene, 41659 Neighboring gene STARR-seq mESC enhancer starr_43686 Neighboring gene STARR-seq mESC enhancer starr_43689 Neighboring gene predicted gene, 34326 Neighboring gene STARR-seq mESC enhancer starr_43691 Neighboring gene STARR-seq mESC enhancer starr_43692 Neighboring gene STARR-seq mESC enhancer starr_43693 Neighboring gene predicted gene, 53196 Neighboring gene predicted gene, 26682

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Human genome-wide association and mouse knockout approaches identify platelet supervillin as an inhibitor of thrombus formation under shear stress. Edelstein LC, et al. Circulation, 2012 Jun 5. PMID 22550155, Free PMC Article
  2. Archvillin, a muscle-specific isoform of supervillin, is an early expressed component of the costameric membrane skeleton. Oh SW, et al. J Cell Sci, 2003 Jun 1. PMID 12711699
  3. Supervillin Is a Component of the Hair Cell's Cuticular Plate and the Head Plates of Organ of Corti Supporting Cells. Pollock LM, et al. PLoS One, 2016. PMID 27415442, Free PMC Article
  4. Gamma-sarcoglycan is required for the response of archvillin to mechanical stimulation in skeletal muscle. Spinazzola JM, et al. Hum Mol Genet, 2015 May 1. PMID 25605665, Free PMC Article
  5. Dual role of Fam208a during zygotic cleavage and early embryonic development. Gresakova V, et al. Exp Cell Res, 2021 Sep 15. PMID 34216590

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. supervillin, an F-actin cross-linking protein, localizes to cuticular plates in hair cells of the mouse cochlea and vestibule. Supervillin localizes near the apicolateral margins within the head plates of Deiters' cells and outer pillar cells, and proximal to the apicolateral margins of inner phalangeal cells. Overall, supervillin localization suggests this protein may shape the surface structure of the organ of Corti.
    Title: Supervillin Is a Component of the Hair Cell's Cuticular Plate and the Head Plates of Organ of Corti Supporting Cells.
  2. These results position archvillin as a mechanically sensitive component of the dystrophin complex and demonstrate that signaling defects caused by loss of gamma-SG occur both at the sarcolemma and in the nucleus.
    Title: Gamma-sarcoglycan is required for the response of archvillin to mechanical stimulation in skeletal muscle.
  3. Human genome-wide association and mouse knockout approaches identify platelet supervillin as an inhibitor of thrombus formation under shear stress.
    Title: Human genome-wide association and mouse knockout approaches identify platelet supervillin as an inhibitor of thrombus formation under shear stress.
  4. archvillin is among the first costameric proteins to assemble during myogenesis and that it contributes to myogenic membrane structure and differentiation.
    Title: Archvillin, a muscle-specific isoform of supervillin, is an early expressed component of the costameric membrane skeleton.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (4)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin filament binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables actin filament binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-4,5-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in actin filament severing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin polymerization or depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in barbed-end actin filament capping IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within muscle cell differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in skeletal muscle tissue development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
located_in cell periphery IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in costamere IDA
Inferred from Direct Assay
more info
 PubMed 
located_in costamere ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in focal adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in sarcolemma IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
supervillin
Names
archvillin
p205/p250

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347449.1 → NP_001334378.1  supervillin isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks multiple in-frame exons in the 5' coding region, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
    Source sequence(s)
    AC115928, AC124770, BP761556
    Consensus CDS
    CCDS84352.1
    UniProtKB/TrEMBL
    E3VVQ8
    Conserved Domains (6) summary
    smart00153
    Location:1731 → 1766
    VHP; Villin headpiece domain
    cd11280
    Location:1115 → 1215
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:1431 → 1536
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:994 → 1086
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:1298 → 1411
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    cl15697
    Location:1553 → 1675
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

  2. NM_001405277.1 → NP_001392206.1  supervillin isoform c

    Status: VALIDATED

    Source sequence(s)
    AC115928, AC124770

  3. NM_001405278.1 → NP_001392207.1  supervillin isoform d

    Status: VALIDATED

    Source sequence(s)
    AC115928, AC124770

  4. NM_001405280.1 → NP_001392209.1  supervillin isoform d

    Status: VALIDATED

    Source sequence(s)
    AC115928, AC124770

  5. NM_001405281.1 → NP_001392210.1  supervillin isoform d

    Status: VALIDATED

    Source sequence(s)
    AC115928, AC124770

  6. NM_001405282.1 → NP_001392211.1  supervillin isoform a

    Status: VALIDATED

    Source sequence(s)
    AC115928, AC124770
    UniProtKB/Swiss-Prot
    E9Q983, Q8K4L3
    Related
    ENSMUSP00000119803.2, ENSMUST00000140448.8

  7. NM_001405290.1 → NP_001392219.1  supervillin isoform d

    Status: VALIDATED

    Source sequence(s)
    AC115928, AC124770

  8. NM_153153.4 → NP_694793.1  supervillin isoform a

    See identical proteins and their annotated locations for NP_694793.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AC115928, AC124770
    Consensus CDS
    CCDS37720.1
    UniProtKB/Swiss-Prot
    E9Q983, Q8K4L3
    UniProtKB/TrEMBL
    A0A1B0GS91
    Related
    ENSMUSP00000025079.10, ENSMUST00000025079.16
    Conserved Domains (6) summary
    smart00153
    Location:2135 → 2170
    VHP; Villin headpiece domain
    cd11280
    Location:1519 → 1619
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:1835 → 1940
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:1398 → 1494
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:1702 → 1815
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    cl15697
    Location:1957 → 2079
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    4920497..5119290
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161085.1 → XP_036016978.1  supervillin isoform X12

    UniProtKB/TrEMBL
    Q8K4L2
    Conserved Domains (4) summary
    cd11280
    Location:1536 → 1636
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:1415 → 1507
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:1719 → 1832
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    cl15697
    Location:1852 → 1925
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

  2. XM_006525791.3 → XP_006525854.1  supervillin isoform X1

    See identical proteins and their annotated locations for XP_006525854.1

    UniProtKB/TrEMBL
    A0A1B0GS91
    Conserved Domains (6) summary
    smart00153
    Location:2152 → 2187
    VHP; Villin headpiece domain
    cd11280
    Location:1536 → 1636
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:1852 → 1957
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:1415 → 1511
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:1719 → 1832
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    cl15697
    Location:1974 → 2096
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

  3. XM_030250413.2 → XP_030106273.1  supervillin isoform X13

    UniProtKB/TrEMBL
    E3VVQ8
    Conserved Domains (7) summary
    smart00153
    Location:1834 → 1869
    VHP; Villin headpiece domain
    cd11280
    Location:1218 → 1318
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:1534 → 1639
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:1097 → 1189
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:1401 → 1514
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    PTZ00441
    Location:177 → 335
    PTZ00441; sporozoite surface protein 2 (SSP2); Provisional
    cl15697
    Location:1656 → 1778
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

  4. XM_030250414.2 → XP_030106274.1  supervillin isoform X14

    UniProtKB/TrEMBL
    E3VVQ8
    Conserved Domains (6) summary
    smart00153
    Location:1779 → 1814
    VHP; Villin headpiece domain
    cd11280
    Location:1163 → 1263
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:1479 → 1584
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:1042 → 1138
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:1346 → 1459
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    cl15697
    Location:1601 → 1723
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

  5. XM_036161087.1 → XP_036016980.1  supervillin isoform X17

    UniProtKB/TrEMBL
    E3VVQ8
    Related
    ENSMUSP00000119287.2, ENSMUST00000143254.8
    Conserved Domains (6) summary
    smart00153
    Location:1731 → 1766
    VHP; Villin headpiece domain
    cd11280
    Location:1115 → 1215
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:1431 → 1536
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:994 → 1086
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:1298 → 1411
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    cl15697
    Location:1553 → 1675
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

  6. XM_006525789.3 → XP_006525852.1  supervillin isoform X1

    See identical proteins and their annotated locations for XP_006525852.1

    UniProtKB/TrEMBL
    A0A1B0GS91
    Conserved Domains (6) summary
    smart00153
    Location:2152 → 2187
    VHP; Villin headpiece domain
    cd11280
    Location:1536 → 1636
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:1852 → 1957
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:1415 → 1511
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:1719 → 1832
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    cl15697
    Location:1974 → 2096
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

  7. XM_011246879.3 → XP_011245181.1  supervillin isoform X5

    UniProtKB/TrEMBL
    E9Q3Z5
    Conserved Domains (6) summary
    smart00153
    Location:2120 → 2155
    VHP; Villin headpiece domain
    cd11280
    Location:1504 → 1604
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:1820 → 1925
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:1383 → 1475
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:1687 → 1800
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    cl15697
    Location:1942 → 2064
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

  8. XM_011246876.3 → XP_011245178.1  supervillin isoform X2

    UniProtKB/TrEMBL
    A0A1B0GS91
    Conserved Domains (6) summary
    smart00153
    Location:2151 → 2186
    VHP; Villin headpiece domain
    cd11280
    Location:1535 → 1635
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:1851 → 1956
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:1414 → 1510
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:1718 → 1831
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    cl15697
    Location:1973 → 2095
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

  9. XM_006525792.3 → XP_006525855.1  supervillin isoform X1

    See identical proteins and their annotated locations for XP_006525855.1

    UniProtKB/TrEMBL
    A0A1B0GS91
    Conserved Domains (6) summary
    smart00153
    Location:2152 → 2187
    VHP; Villin headpiece domain
    cd11280
    Location:1536 → 1636
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:1852 → 1957
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:1415 → 1511
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:1719 → 1832
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    cl15697
    Location:1974 → 2096
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

  10. XM_036161071.1 → XP_036016964.1  supervillin isoform X1

    UniProtKB/TrEMBL
    A0A1B0GS91
    Conserved Domains (6) summary
    smart00153
    Location:2152 → 2187
    VHP; Villin headpiece domain
    cd11280
    Location:1536 → 1636
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:1852 → 1957
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:1415 → 1511
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:1719 → 1832
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    cl15697
    Location:1974 → 2096
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

  11. XM_036161078.1 → XP_036016971.1  supervillin isoform X6

    UniProtKB/TrEMBL
    E9Q3Z5
    Conserved Domains (6) summary
    smart00153
    Location:2104 → 2139
    VHP; Villin headpiece domain
    cd11280
    Location:1488 → 1588
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:1804 → 1909
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:1367 → 1459
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:1671 → 1784
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    cl15697
    Location:1926 → 2048
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

  12. XM_011246881.3 → XP_011245183.1  supervillin isoform X8

    UniProtKB/TrEMBL
    E9Q3Z5
    Conserved Domains (6) summary
    smart00153
    Location:2097 → 2132
    VHP; Villin headpiece domain
    cd11280
    Location:1481 → 1581
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:1797 → 1902
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:1360 → 1456
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:1664 → 1777
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    cl15697
    Location:1919 → 2041
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

  13. XM_036161081.1 → XP_036016974.1  supervillin isoform X10

    UniProtKB/TrEMBL
    E9Q3Z5
    Conserved Domains (6) summary
    smart00153
    Location:2081 → 2116
    VHP; Villin headpiece domain
    cd11280
    Location:1465 → 1565
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:1781 → 1886
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:1344 → 1440
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:1648 → 1761
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    cl15697
    Location:1903 → 2025
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

  14. XM_011246878.4 → XP_011245180.1  supervillin isoform X4

    See identical proteins and their annotated locations for XP_011245180.1

    UniProtKB/Swiss-Prot
    E9Q983, Q8K4L3
    UniProtKB/TrEMBL
    A0A1B0GS91
    Related
    ENSMUSP00000115078.2, ENSMUST00000126977.8
    Conserved Domains (6) summary
    smart00153
    Location:2135 → 2170
    VHP; Villin headpiece domain
    cd11280
    Location:1519 → 1619
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:1835 → 1940
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:1398 → 1494
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:1702 → 1815
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    cl15697
    Location:1957 → 2079
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

  15. XM_011246880.3 → XP_011245182.1  supervillin isoform X7

    UniProtKB/TrEMBL
    E9Q3Z5
    Conserved Domains (6) summary
    smart00153
    Location:2103 → 2138
    VHP; Villin headpiece domain
    cd11280
    Location:1487 → 1587
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:1803 → 1908
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:1366 → 1458
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:1670 → 1783
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    cl15697
    Location:1925 → 2047
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

  16. XM_036161083.1 → XP_036016976.1  supervillin isoform X11

    UniProtKB/TrEMBL
    E9Q3Z5
    Conserved Domains (6) summary
    smart00153
    Location:2080 → 2115
    VHP; Villin headpiece domain
    cd11280
    Location:1464 → 1564
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:1780 → 1885
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:1343 → 1439
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:1647 → 1760
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    cl15697
    Location:1902 → 2024
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

  17. XM_011246882.4 → XP_011245184.1  supervillin isoform X13

    UniProtKB/TrEMBL
    E3VVQ8
    Conserved Domains (7) summary
    smart00153
    Location:1834 → 1869
    VHP; Villin headpiece domain
    cd11280
    Location:1218 → 1318
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:1534 → 1639
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:1097 → 1189
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:1401 → 1514
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    PTZ00441
    Location:177 → 335
    PTZ00441; sporozoite surface protein 2 (SSP2); Provisional
    cl15697
    Location:1656 → 1778
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

  18. XM_006525800.5 → XP_006525863.1  supervillin isoform X14

    See identical proteins and their annotated locations for XP_006525863.1

    UniProtKB/TrEMBL
    E3VVQ8
    Conserved Domains (6) summary
    smart00153
    Location:1779 → 1814
    VHP; Villin headpiece domain
    cd11280
    Location:1163 → 1263
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:1479 → 1584
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:1042 → 1138
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:1346 → 1459
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    cl15697
    Location:1601 → 1723
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

  19. XM_017317865.3 → XP_017173354.1  supervillin isoform X15

    UniProtKB/TrEMBL
    E3VVQ8
    Conserved Domains (6) summary
    smart00153
    Location:1763 → 1798
    VHP; Villin headpiece domain
    cd11280
    Location:1147 → 1247
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:1463 → 1568
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:1026 → 1122
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:1330 → 1443
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    cl15697
    Location:1585 → 1707
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

  20. XM_011246884.3 → XP_011245186.1  supervillin isoform X16

    UniProtKB/TrEMBL
    E3VVQ8
    Conserved Domains (6) summary
    smart00153
    Location:1747 → 1782
    VHP; Villin headpiece domain
    cd11280
    Location:1131 → 1231
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:1447 → 1552
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:1010 → 1102
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:1314 → 1427
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    cl15697
    Location:1569 → 1691
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

  21. XM_006525801.5 → XP_006525864.1  supervillin isoform X14

    See identical proteins and their annotated locations for XP_006525864.1

    UniProtKB/TrEMBL
    E3VVQ8
    Conserved Domains (6) summary
    smart00153
    Location:1779 → 1814
    VHP; Villin headpiece domain
    cd11280
    Location:1163 → 1263
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:1479 → 1584
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:1042 → 1138
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:1346 → 1459
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    cl15697
    Location:1601 → 1723
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

  22. XM_030250415.2 → XP_030106275.1  supervillin isoform X17

    UniProtKB/TrEMBL
    E3VVQ8
    Conserved Domains (6) summary
    smart00153
    Location:1731 → 1766
    VHP; Villin headpiece domain
    cd11280
    Location:1115 → 1215
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:1431 → 1536
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:994 → 1086
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:1298 → 1411
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    cl15697
    Location:1553 → 1675
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

  23. XM_036161086.1 → XP_036016979.1  supervillin isoform X14

    UniProtKB/TrEMBL
    E3VVQ8
    Conserved Domains (6) summary
    smart00153
    Location:1779 → 1814
    VHP; Villin headpiece domain
    cd11280
    Location:1163 → 1263
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:1479 → 1584
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:1042 → 1138
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:1346 → 1459
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    cl15697
    Location:1601 → 1723
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

  24. XM_006525790.1 → XP_006525853.1  supervillin isoform X1

    See identical proteins and their annotated locations for XP_006525853.1

    UniProtKB/TrEMBL
    A0A1B0GS91
    Conserved Domains (6) summary
    smart00153
    Location:2152 → 2187
    VHP; Villin headpiece domain
    cd11280
    Location:1536 → 1636
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:1852 → 1957
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:1415 → 1511
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:1719 → 1832
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    cl15697
    Location:1974 → 2096
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

  25. XM_006525793.5 → XP_006525856.1  supervillin isoform X1

    See identical proteins and their annotated locations for XP_006525856.1

    UniProtKB/TrEMBL
    A0A1B0GS91
    Conserved Domains (6) summary
    smart00153
    Location:2152 → 2187
    VHP; Villin headpiece domain
    cd11280
    Location:1536 → 1636
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:1852 → 1957
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:1415 → 1511
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:1719 → 1832
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    cl15697
    Location:1974 → 2096
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

  26. XM_036161077.1 → XP_036016970.1  supervillin isoform X4

    UniProtKB/Swiss-Prot
    E9Q983, Q8K4L3
    UniProtKB/TrEMBL
    A0A1B0GS91
    Conserved Domains (6) summary
    smart00153
    Location:2135 → 2170
    VHP; Villin headpiece domain
    cd11280
    Location:1519 → 1619
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:1835 → 1940
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:1398 → 1494
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:1702 → 1815
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    cl15697
    Location:1957 → 2079
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

  27. XM_036161080.1 → XP_036016973.1  supervillin isoform X9

    UniProtKB/TrEMBL
    E9Q3Z5
    Conserved Domains (6) summary
    smart00153
    Location:2096 → 2131
    VHP; Villin headpiece domain
    cd11280
    Location:1480 → 1580
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:1796 → 1901
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:1359 → 1455
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:1663 → 1776
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    cl15697
    Location:1918 → 2040
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

  28. XM_036161079.1 → XP_036016972.1  supervillin isoform X6

    UniProtKB/TrEMBL
    E9Q3Z5
    Conserved Domains (6) summary
    smart00153
    Location:2104 → 2139
    VHP; Villin headpiece domain
    cd11280
    Location:1488 → 1588
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:1804 → 1909
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:1367 → 1459
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:1671 → 1784
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    cl15697
    Location:1926 → 2048
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

  29. XM_036161082.1 → XP_036016975.1  supervillin isoform X10

    UniProtKB/TrEMBL
    E9Q3Z5
    Conserved Domains (6) summary
    smart00153
    Location:2081 → 2116
    VHP; Villin headpiece domain
    cd11280
    Location:1465 → 1565
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:1781 → 1886
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:1344 → 1440
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:1648 → 1761
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    cl15697
    Location:1903 → 2025
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

  30. XM_036161084.1 → XP_036016977.1  supervillin isoform X11

    UniProtKB/TrEMBL
    E9Q3Z5
    Related
    ENSMUSP00000115223.2, ENSMUST00000127297.8
    Conserved Domains (6) summary
    smart00153
    Location:2080 → 2115
    VHP; Villin headpiece domain
    cd11280
    Location:1464 → 1564
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:1780 → 1885
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:1343 → 1439
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:1647 → 1760
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    cl15697
    Location:1902 → 2024
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_178046.3: Suppressed sequence

    Description
    NM_178046.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K4L3.1 GenPept UniProtKB/Swiss-Prot:Q8K4L3

Gene LinkOut

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