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Klhl14 kelch-like 14 [ Mus musculus (house mouse) ]

Gene ID: 225266, updated on 11-Apr-2024

Summary

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Official Symbol
Klhl14provided by MGI
Official Full Name
kelch-like 14provided by MGI
Primary source
MGI:MGI:1921249
See related
Ensembl:ENSMUSG00000042514 AllianceGenome:MGI:1921249
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
printor; 6330403N15Rik
Summary
Located in neuron projection and neuronal cell body. Is expressed in several structures, including central nervous system; endocrine gland; metanephros; sensory organ; and thymus primordium. Orthologous to human KLHL14 (kelch like family member 14). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in adrenal adult (RPKM 16.7), genital fat pad adult (RPKM 4.1) and 6 other tissues See more
Orthologs
human all
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Genomic context

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See Klhl14 in Genome Data Viewer
Location:
18 A2; 18 11.96 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (21683436..21805986, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (21550379..21672929, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_44013 Neighboring gene STARR-seq mESC enhancer starr_44015 Neighboring gene predicted gene, 22886 Neighboring gene STARR-seq mESC enhancer starr_44016 Neighboring gene predicted gene, 31646 Neighboring gene pyruvate kinase, muscle pseudogene Neighboring gene STARR-seq mESC enhancer starr_44017 Neighboring gene STARR-seq mESC enhancer starr_44018 Neighboring gene RIKEN cDNA 4930426D05 gene Neighboring gene STARR-seq mESC enhancer starr_44019 Neighboring gene coiled coil domain containing 178 Neighboring gene STARR-seq mESC enhancer starr_44020 Neighboring gene STARR-seq mESC enhancer starr_44021 Neighboring gene STARR-seq mESC enhancer starr_44023 Neighboring gene STARR-seq mESC enhancer starr_44024 Neighboring gene ribosomal protein SA pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Kelch-like protein 14 promotes B-1a but suppresses B-1b cell development. Li S, et al. Int Immunol, 2018 Jun 26. PMID 29939266
  2. Crim1 and Kelch-like 14 exert complementary dual-directional developmental control over segmentally specific corticospinal axon projection targeting. Sahni V, et al. Cell Rep, 2021 Oct 19. PMID 34686337, Free PMC Article
  3. A Role for Dystonia-Associated Genes in Spinal GABAergic Interneuron Circuitry. Zhang J, et al. Cell Rep, 2017 Oct 17. PMID 29045835, Free PMC Article
  4. Printor, a novel torsinA-interacting protein implicated in dystonia pathogenesis. Giles LM, et al. J Biol Chem, 2009 Aug 7. PMID 19535332, Free PMC Article
  5. Genome-wide expression analysis of Ptf1a- and Ascl1-deficient mice reveals new markers for distinct dorsal horn interneuron populations contributing to nociceptive reflex plasticity. Wildner H, et al. J Neurosci, 2013 Apr 24. PMID 23616538, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Crim1 and Kelch-like 14 exert complementary dual-directional developmental control over segmentally specific corticospinal axon projection targeting.
    Title: Crim1 and Kelch-like 14 exert complementary dual-directional developmental control over segmentally specific corticospinal axon projection targeting.
  2. KLHL14 promotes B-1a development in mice
    Title: Kelch-like protein 14 promotes B-1a but suppresses B-1b cell development.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in aggresome ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in neuron projection IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
kelch-like protein 14
Names
protein interactor of Torsin-1A
protein interactor of torsinA

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081403.2 → NP_001074872.1  kelch-like protein 14

    See identical proteins and their annotated locations for NP_001074872.1

    Status: VALIDATED

    Source sequence(s)
    AC140283, AC158903
    Consensus CDS
    CCDS37748.1
    UniProtKB/Swiss-Prot
    Q69ZK5, Q9CU51
    Related
    ENSMUSP00000113755.2, ENSMUST00000122333.2
    Conserved Domains (4) summary
    PHA03098
    Location:140 → 602
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:365 → 412
    Kelch; KELCH repeat [structural motif]
    cd18243
    Location:1 → 190
    BTB_POZ_KLHL14_printor; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 14 (KLHL14)
    cd18453
    Location:183 → 284
    BACK_KLHL14; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 14 (KLHL14)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    21683436..21805986 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006525823.4 → XP_006525886.1  kelch-like protein 14 isoform X1

    See identical proteins and their annotated locations for XP_006525886.1

    UniProtKB/Swiss-Prot
    Q69ZK5, Q9CU51
    Related
    ENSMUSP00000042015.5, ENSMUST00000049105.11
    Conserved Domains (4) summary
    PHA03098
    Location:140 → 602
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:365 → 412
    Kelch; KELCH repeat [structural motif]
    cd18243
    Location:1 → 190
    BTB_POZ_KLHL14_printor; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 14 (KLHL14)
    cd18453
    Location:183 → 284
    BACK_KLHL14; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 14 (KLHL14)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q69ZK5.2 GenPept UniProtKB/Swiss-Prot:Q69ZK5

Gene LinkOut

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