Alpk2 alpha-kinase 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Alpk2provided by MGI
Official Full Name: alpha-kinase 2provided by MGI
Primary source: MGI:MGI:2449492
See related: Ensembl:ENSMUSG00000032845 AllianceGenome:MGI:2449492
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Hak; Gm549
Summary: Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Predicted to be involved in several processes, including epicardium morphogenesis; heart development; and negative regulation of Wnt signaling pathway involved in heart development. Predicted to act upstream of or within regulation of gene expression. Predicted to be located in plasma membrane. Predicted to colocalize with basolateral plasma membrane. Orthologous to human ALPK2 (alpha kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in heart adult (RPKM 10.5) and mammary gland adult (RPKM 0.7) See more
Orthologs: human all
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Genomic context

Location:: 18 E1; 18 38.41 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (65398600..65526959, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (65265529..65393888, complement)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

murine Alpk2-gKO models developed in this work display no overt cardiac phenotype. Our results suggest ALPK2, as a rapidly evolving gene, lost its essential cardiac functions in mammals.
Title: Atypical ALPK2 kinase is not essential for cardiac development and function.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D18Mit182 (e-PCR), detects polymorphism
- UniSTS:128202

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cardiac muscle cell development	ISO Inferred from Sequence Orthology more info
involved_in epicardium morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in establishment of cell polarity	ISO Inferred from Sequence Orthology more info
involved_in heart morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of Wnt signaling pathway involved in heart development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of gene expression	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
colocalizes_with basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: alpha-protein kinase 2

Names: heart alpha-kinase; heart alpha-protein kinase

NP_001032371.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001037294.1 → NP_001032371.1 alpha-protein kinase 2

See identical proteins and their annotated locations for NP_001032371.1

Status: VALIDATED

Source sequence(s)

AC157910

Consensus CDS

CCDS50310.1

UniProtKB/Swiss-Prot

E9QL35, Q91ZB0

Related

ENSMUSP00000048752.8, ENSMUST00000035548.16

Conserved Domains (4) summary

cd00096
Location:29 → 101

Ig; Immunoglobulin domain

smart00410
Location:1775 → 1847

IG_like; Immunoglobulin like

smart00811
Location:1879 → 2098

Alpha_kinase; Alpha-kinase family

pfam07679
Location:14 → 104

I-set; Immunoglobulin I-set domain