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Haus1 HAUS augmin-like complex, subunit 1 [ Mus musculus (house mouse) ]

Gene ID: 225745, updated on 5-Mar-2024

Summary

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Official Symbol
Haus1provided by MGI
Official Full Name
HAUS augmin-like complex, subunit 1provided by MGI
Primary source
MGI:MGI:2385076
See related
Ensembl:ENSMUSG00000041840 AllianceGenome:MGI:2385076
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ccdc5; HEI-C
Summary
Predicted to be involved in centrosome cycle and spindle assembly. Predicted to act upstream of or within cell division. Predicted to be located in centrosome and mitotic spindle microtubule. Predicted to be part of HAUS complex. Predicted to be active in cytosol. Is expressed in alimentary system; brain ventricular layer; chondrocranium; liver lobe; and renal cortex. Orthologous to human HAUS1 (HAUS augmin like complex subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 6.2), testis adult (RPKM 5.4) and 19 other tissues See more
Orthologs
human all
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Genomic context

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Location:
18 E3; 18 52.38 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (77844977..77861602, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (77757277..77773885, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A330094K24 gene Neighboring gene RIKEN cDNA 5730552O08 gene Neighboring gene STARR-seq mESC enhancer starr_45128 Neighboring gene STARR-positive B cell enhancer ABC_E4255 Neighboring gene STARR-seq mESC enhancer starr_45130 Neighboring gene predicted gene, 52331 Neighboring gene STARR-seq mESC enhancer starr_45133 Neighboring gene RIKEN cDNA F830208F22 gene Neighboring gene ATP synthase F1 subunit alpha Neighboring gene STARR-positive B cell enhancer mm9_chr18:78030749-78031049 Neighboring gene proline-serine-threonine phosphatase-interacting protein 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:78061325-78061621 Neighboring gene STARR-positive B cell enhancer ABC_E2514 Neighboring gene ectopic P-granules 5 autophagy tethering factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. TRIM8 interacts with KIF11 and KIFC1 and controls bipolar spindle formation and chromosomal stability. Venuto S, et al. Cancer Lett, 2020 Mar 31. PMID 31904480
  2. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
  3. Systematic analysis of human protein complexes identifies chromosome segregation proteins. Hutchins JR, et al. Science, 2010 Apr 30. PMID 20360068, Free PMC Article
  4. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Hein MY, et al. Cell, 2015 Oct 22. PMID 26496610

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC36238

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in centrosome cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in centrosome cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spindle assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of HAUS complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of HAUS complex ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in mitotic spindle microtubule ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
HAUS augmin-like complex subunit 1
Names
coiled-coil domain-containing protein 5
spindle associated

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357531.1 → NP_001344460.1  HAUS augmin-like complex subunit 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC162291
    Consensus CDS
    CCDS89282.1
    UniProtKB/TrEMBL
    A0A494BB26
    Conserved Domains (1) summary
    COG1196
    Location:52 → 286
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  2. NM_001357532.1 → NP_001344461.1  HAUS augmin-like complex subunit 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC162291
    Consensus CDS
    CCDS89282.1
    UniProtKB/TrEMBL
    A0A494BB26
    Related
    ENSMUSP00000158336.2, ENSMUST00000236234.2
    Conserved Domains (1) summary
    COG1196
    Location:52 → 286
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  3. NM_001357533.1 → NP_001344462.1  HAUS augmin-like complex subunit 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC162291
    Consensus CDS
    CCDS89282.1
    UniProtKB/TrEMBL
    A0A494BB26
    Conserved Domains (1) summary
    COG1196
    Location:52 → 286
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  4. NM_146089.3 → NP_666201.1  HAUS augmin-like complex subunit 1 isoform 1

    See identical proteins and their annotated locations for NP_666201.1

    Status: VALIDATED

    Source sequence(s)
    AC162291, AK146923, BY106914, CD545676
    Consensus CDS
    CCDS29357.1
    UniProtKB/Swiss-Prot
    Q3UIH2, Q8BHX1, Q8R1M1
    Related
    ENSMUSP00000035826.8, ENSMUST00000048192.9
    Conserved Domains (1) summary
    COG1196
    Location:37 → 271
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    77844977..77861602 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161131.1 → XP_036017024.1  HAUS augmin-like complex subunit 1 isoform X2

    Conserved Domains (1) summary
    COG1196
    Location:43 → 195
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  2. XM_036161132.1 → XP_036017025.1  HAUS augmin-like complex subunit 1 isoform X2

    Conserved Domains (1) summary
    COG1196
    Location:43 → 195
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  3. XM_036161130.1 → XP_036017023.1  HAUS augmin-like complex subunit 1 isoform X1

    UniProtKB/TrEMBL
    A0A494BB26
    Conserved Domains (1) summary
    COG1196
    Location:52 → 286
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  4. XM_030250449.2 → XP_030106309.1  HAUS augmin-like complex subunit 1 isoform X1

    UniProtKB/TrEMBL
    A0A494BB26
    Conserved Domains (1) summary
    COG1196
    Location:52 → 286
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  5. XM_036161133.1 → XP_036017026.1  HAUS augmin-like complex subunit 1 isoform X2

    Conserved Domains (1) summary
    COG1196
    Location:43 → 195
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

RNA

  1. XR_004939849.1 RNA Sequence

  2. XR_004939848.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BHX1.2 GenPept UniProtKB/Swiss-Prot:Q8BHX1

Gene LinkOut

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