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Zbtb17 zinc finger and BTB domain containing 17 [ Mus musculus (house mouse) ]

Gene ID: 22642, updated on 5-Mar-2024

Summary

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Official Symbol
Zbtb17provided by MGI
Official Full Name
zinc finger and BTB domain containing 17provided by MGI
Primary source
MGI:MGI:107410
See related
Ensembl:ENSMUSG00000006215 AllianceGenome:MGI:107410
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lp-1; Miz1; mZ13; Zfp100
Summary
Enables DNA binding activity. Acts upstream of or within ectoderm development; gastrulation with mouth forming second; and positive regulation of transcription, DNA-templated. Located in nucleus. Is expressed in early conceptus; eye; genitourinary system; limb; and trunk somite. Orthologous to human ZBTB17 (zinc finger and BTB domain containing 17). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in whole brain E14.5 (RPKM 15.8), thymus adult (RPKM 15.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 D3; 4 74.17 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (141171984..141195248)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (141444673..141467937)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene heat shock protein family, member 7 (cardiovascular) Neighboring gene steroid receptor associated and regulated protein Neighboring gene predicted gene, 42337 Neighboring gene STARR-positive B cell enhancer mm9_chr4:141033664-141033965 Neighboring gene spen family transcription repressor Neighboring gene RIKEN cDNA B330016D10 gene Neighboring gene STARR-positive B cell enhancer ABC_E6250 Neighboring gene predicted gene 4123

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The zinc finger protein Miz1 suppresses liver tumorigenesis by restricting hepatocyte-driven macrophage activation and inflammation. Zhang W, et al. Immunity, 2021 Jun 8. PMID 34038747
  2. Epithelial cell-specific loss of function of Miz1 causes a spontaneous COPD-like phenotype and up-regulates Ace2 expression in mice. Do-Umehara HC, et al. Sci Adv, 2020 Aug. PMID 32851183, Free PMC Article
  3. Deletion of the Miz-1 POZ Domain Increases Efficacy of Cytarabine Treatment in T- and B-ALL/Lymphoma Mouse Models. Ross J, et al. Cancer Res, 2019 Aug 15. PMID 31273062
  4. Late onset neuropathy with spontaneous clinical remission in mice lacking the POZ domain of the transcription factor Myc-interacting zinc finger protein 1 (Miz1) in Schwann cells. Sanz-Moreno A, et al. J Biol Chem, 2015 Jan 9. PMID 25416780, Free PMC Article
  5. Miz1 is required to maintain autophagic flux. Wolf E, et al. Nat Commun, 2013. PMID 24088869, Free PMC Article

See all (64) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A TNFalpha/Miz1-positive feedback loop inhibits mitophagy in hepatocytes and propagates non-alcoholic steatohepatitis.
    Title: A TNFα/Miz1-positive feedback loop inhibits mitophagy in hepatocytes and propagates non-alcoholic steatohepatitis.
  2. Miz1 promotes KRAS-driven lung tumorigenesis by repressing the protocadherin Pcdh10.
    Title: Miz1 promotes KRAS-driven lung tumorigenesis by repressing the protocadherin Pcdh10.
  3. The zinc finger protein Miz1 suppresses liver tumorigenesis by restricting hepatocyte-driven macrophage activation and inflammation.
    Title: The zinc finger protein Miz1 suppresses liver tumorigenesis by restricting hepatocyte-driven macrophage activation and inflammation.
  4. Identification of the SARS-CoV-2 Entry Receptor ACE2 as a Direct Target for Transcriptional Repression by Miz1.
    Title: Identification of the SARS-CoV-2 Entry Receptor ACE2 as a Direct Target for Transcriptional Repression by Miz1.
  5. Epithelial cell-specific loss of function of Miz1 causes a spontaneous COPD-like phenotype and up-regulates Ace2 expression in mice.
    Title: Epithelial cell-specific loss of function of Miz1 causes a spontaneous COPD-like phenotype and up-regulates Ace2 expression in mice.
  6. A functional Miz-1 is required for the development of T-acute lymphoblastic leukemia and B-acute lymphoblastic leukemia /lymphoma.
    Title: Deletion of the Miz-1 POZ Domain Increases Efficacy of Cytarabine Treatment in T- and B-ALL/Lymphoma Mouse Models.
  7. we report sustained Schwann cell proliferation caused by an increased expression of the direct Miz1 target gene Kdm8, encoding a H3K36me2 demethylase
    Title: Miz1 Controls Schwann Cell Proliferation via H3K36(me2) Demethylase Kdm8 to Prevent Peripheral Nerve Demyelination.
  8. rather than via E-Box binding, cMyc acts in the dorsal neural tube by interacting with another transcription factor, Miz1, to promote self-renewal. The finding that cMyc operates in a non-canonical manner in the premigratory neural crest highlights the importance of examining its role at specific time points and in an in vivo context.
    Title: cMyc Regulates the Size of the Premigratory Neural Crest Stem Cell Pool.
  9. the Myc/Miz1 interaction is a defining hallmark of Sonic Hedgehog medulloblastomas development
    Title: The Interaction of Myc with Miz1 Defines Medulloblastoma Subgroup Identity.
  10. Miz-1 regulates translation of Trp53 via ribosomal protein L22 in cells undergoing V(D)J recombination.
    Title: Miz-1 regulates translation of Trp53 via ribosomal protein L22 in cells undergoing V(D)J recombination.
Submit: New GeneRIF Correction See all GeneRIFs (27)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables core promoter sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coactivator binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_negative_effect G1 to G0 transition ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within ectoderm development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within gastrulation with mouth forming second IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein-DNA complex ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc finger and BTB domain-containing protein 17
Names
polyomavirus late initiator promoter-binding protein
zfp-100
zinc finger protein 100
zinc finger protein 151
zinc finger protein Z13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001378826.1 → NP_001365755.1  zinc finger and BTB domain-containing protein 17 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL670285
    UniProtKB/TrEMBL
    A6H6B9
    Related
    ENSMUST00000142020.8
    Conserved Domains (5) summary
    COG5048
    Location:322 → 653
    COG5048; FOG: Zn-finger [General function prediction only]
    PRK07003
    Location:115 → 266
    PRK07003; DNA polymerase III subunit gamma/tau
    sd00017
    Location:492 → 512
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:632 → 651
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18206
    Location:2 → 113
    BTB_POZ_ZBTB17_MIZ1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17)

  2. NM_001378827.1 → NP_001365756.1  zinc finger and BTB domain-containing protein 17 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL670285
    UniProtKB/TrEMBL
    A6H6B9
    Conserved Domains (5) summary
    COG3170
    Location:16 → 118
    FimV; Tfp pilus assembly protein FimV [Cell motility, Extracellular structures]
    COG5048
    Location:221 → 552
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:391 → 411
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:531 → 550
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl38908
    Location:1 → 37
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

  3. NM_001378828.1 → NP_001365757.1  zinc finger and BTB domain-containing protein 17 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL670285
    UniProtKB/Swiss-Prot
    A2ADB9, Q60699, Q60821
    UniProtKB/TrEMBL
    A6H6B9
    Conserved Domains (5) summary
    COG3170
    Location:92 → 194
    FimV; Tfp pilus assembly protein FimV [Cell motility, Extracellular structures]
    COG5048
    Location:297 → 628
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:467 → 487
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:607 → 626
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18206
    Location:2 → 113
    BTB_POZ_ZBTB17_MIZ1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17)

  4. NM_009541.2 → NP_033567.2  zinc finger and BTB domain-containing protein 17 isoform 1

    See identical proteins and their annotated locations for NP_033567.2

    Status: VALIDATED

    Source sequence(s)
    AK134251, BC145821, BY246264
    Consensus CDS
    CCDS18875.1
    UniProtKB/Swiss-Prot
    A2ADB9, Q60699, Q60821
    UniProtKB/TrEMBL
    A6H6B9
    Related
    ENSMUSP00000006377.7, ENSMUST00000006377.13
    Conserved Domains (5) summary
    COG3170
    Location:92 → 194
    FimV; Tfp pilus assembly protein FimV [Cell motility, Extracellular structures]
    COG5048
    Location:297 → 628
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:467 → 487
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:607 → 626
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18206
    Location:2 → 113
    BTB_POZ_ZBTB17_MIZ1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    141171984..141195248
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q60821.2 GenPept UniProtKB/Swiss-Prot:Q60821

Gene LinkOut

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