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Rnf112 ring finger protein 112 [ Mus musculus (house mouse) ]

Gene ID: 22671, updated on 11-Apr-2024

Summary

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Official Symbol
Rnf112provided by MGI
Official Full Name
ring finger protein 112provided by MGI
Primary source
MGI:MGI:106611
See related
Ensembl:ENSMUSG00000010086 AllianceGenome:MGI:106611
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
bfp; ZNF179; Zfp179; neurolastin
Summary
Enables several functions, including GTP binding activity; GTPase activity; and ubiquitin protein ligase activity. Involved in several processes, including cell death in response to hydrogen peroxide; embryonic brain development; and protein autoubiquitination. Acts upstream of or within G1 to G0 transition involved in cell differentiation; positive regulation of glial cell differentiation; and positive regulation of neuron differentiation. Located in several cellular components, including cytoplasmic vesicle; nuclear body; and postsynaptic density. Is extrinsic component of membrane. Is expressed in several structures, including adrenal gland; alimentary system; brain; genitourinary system; and respiratory system. Orthologous to human RNF112 (ring finger protein 112). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 117.7), cortex adult (RPKM 98.5) and 5 other tissues See more
Orthologs
human all
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Genomic context

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See Rnf112 in Genome Data Viewer
Location:
11 B2; 11 37.96 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (61339243..61345014, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (61448417..61454188, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6994 Neighboring gene nuclear encoded tRNA trytophan 5 (anticodon CCA) Neighboring gene predicted gene 12271 Neighboring gene STARR-positive B cell enhancer ABC_E6995 Neighboring gene microfibrillar-associated protein 4 Neighboring gene mitogen-activated protein kinase 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Neurolastin, a dynamin family GTPase, translocates to mitochondria upon neuronal stress and alters mitochondrial morphology in vivo. Lomash RM, et al. J Biol Chem, 2019 Jul 26. PMID 31177092, Free PMC Article
  2. Rnf112 deletion protects brain against intracerebral hemorrhage (ICH) in mice by inhibiting TLR-4/NF-κB pathway. Zhang F, et al. Biochem Biophys Res Commun, 2018 Dec 9. PMID 30454900
  3. Cloning, genomic structure, and expression of mouse ring finger protein gene Znf179. Zhao Q, et al. Genomics, 1998 May 1. PMID 9615224
  4. Purα regulates the induction of Znf179 transcription during neuronal differentiation. Kuo CJ, et al. Biochem Biophys Res Commun, 2020 Dec 17. PMID 33333713
  5. Increase of zinc finger protein 179 in response to CCAAT/enhancer binding protein delta conferring an antiapoptotic effect in astrocytes of Alzheimer's disease. Wang SM, et al. Mol Neurobiol, 2015 Feb. PMID 24788683, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Puralpha regulates the induction of Znf179 transcription during neuronal differentiation.
    Title: Purα regulates the induction of Znf179 transcription during neuronal differentiation.
  2. Rnf112 expression was highly involved in the progression of intracerebral hemorrhage.
    Title: Rnf112 deletion protects brain against intracerebral hemorrhage (ICH) in mice by inhibiting TLR-4/NF-κB pathway.
  3. Here the authors unveil the important role for the novel E3 ligase Znf179 in TDP-43-mediated neuropathy, and provide a potential therapeutic strategy for combating ALS/ FTLD-U neurodegenerative pathologies.
    Title: Znf179 E3 ligase-mediated TDP-43 polyubiquitination is involved in TDP-43- ubiquitinated inclusions (UBI) (+)-related neurodegenerative pathology.
  4. Rnf112 protein is expressed in most brain areas and mainly in neurons; deletion of both Rnf112 alleles resulted in embryonic lethality associated with defects in embryonic vasculature; results provide evidence for the important functions of Rnf112 in embryo development and in adult brain
    Title: Important Roles of Ring Finger Protein 112 in Embryonic Vascular Development and Brain Functions.
  5. the results obtained in this study show that Znf179 autoregulation through Sp1-dependent mechanism plays an important role in neuroprotection, and NGF-induced Sp1 signaling may help attenuate more extensive (ROS-induced) damage following brain injury
    Title: Specificity protein 1-zinc finger protein 179 pathway is involved in the attenuation of oxidative stress following brain injury.
  6. Study focused on sigma-1 receptor (Sig-1R), a chaperone at endoplasmic reticulum, and investigated its protective functions; results reveal that zinc finger protein 179 plays a novel role in neuroprotection.
    Title: The sigma-1 receptor-zinc finger protein 179 pathway protects against hydrogen peroxide-induced cell injury.
  7. identify neurolastin as a dynamin family GTPase that affects endosome size and spine density.
    Title: Neurolastin, a Dynamin Family GTPase, Regulates Excitatory Synapses and Spine Density.
  8. This study provides the first evidence that ZNF179, PLZF, IGFBP3, and BIK contributed to the novel CEBPD-induced antiapoptotic feature of astrocytes.
    Title: Increase of zinc finger protein 179 in response to CCAAT/enhancer binding protein delta conferring an antiapoptotic effect in astrocytes of Alzheimer's disease.
  9. Induction of the Znf179 gene is associated with p35 expression and p27 protein accumulation, which lead to cell cycle arrest in the G0/G1 phase, and is critical for neuronal differentiation of P19 cells.
    Title: A novel RING finger protein, Znf179, modulates cell cycle exit and neuronal differentiation of P19 embryonal carcinoma cells.
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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within G1 to G0 transition involved in cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in embryonic brain development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endoplasmic reticulum organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
  
involved_in neuron differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of glial cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein autoubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein homooligomerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in response to hydroperoxide IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
  
located_in synaptic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
RING finger protein 112
Names
brain finger protein
zinc finger protein 179
NP_001277953.1
NP_001346059.1
NP_033574.2
XP_006533241.1
XP_006533243.1
XP_006533244.1
XP_006533245.1
XP_006533246.1
XP_006533247.1
XP_006533248.1
XP_017169993.1
XP_017169994.1
XP_030101793.1
XP_036012528.1
XP_036012529.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291024.1 → NP_001277953.1  RING finger protein 112 isoform 2

    See identical proteins and their annotated locations for NP_001277953.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon and uses alternate in-frame splice sites in the 5' coding region, compared to variant 3. It encodes isoform 2, which lacks two separate internal segments and is shorter, compared to isoform 3.
    Source sequence(s)
    BC013139, BY599807, CJ148450
    Consensus CDS
    CCDS78960.1
    UniProtKB/Swiss-Prot
    Q96DY5
    Related
    ENSMUSP00000099722.4, ENSMUST00000102661.4
    Conserved Domains (2) summary
    cd01851
    Location:163 → 361
    GBP; Guanylate-binding protein (GBP) family (N-terminal domain)
    cd16538
    Location:55 → 102
    RING-HC_RNF112; RING finger, HC subclass, found in RING finger protein 112 (RNF112) and similar proteins

  2. NM_001359130.1 → NP_001346059.1  RING finger protein 112 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
    Source sequence(s)
    AK131651, BC013139, BE945765, BY237309
    Consensus CDS
    CCDS88167.1
    Related
    ENSMUSP00000059903.8, ENSMUST00000060255.14
    Conserved Domains (2) summary
    cd16538
    Location:78 → 125
    RING-HC_RNF112; RING finger, HC subclass, found in RING finger protein 112 (RNF112) and similar proteins
    cl38936
    Location:186 → 409
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  3. NM_009548.3 → NP_033574.2  RING finger protein 112 isoform 1

    See identical proteins and their annotated locations for NP_033574.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) uses alternate in-frame splice sites in the 5' coding region, compared to variant 3. It encodes isoform 1, which lacks an internal segment and is shorter, compared to isoform 3.
    Source sequence(s)
    BC013139, BY599807, CJ148450
    Consensus CDS
    CCDS24812.1
    UniProtKB/Swiss-Prot
    Q3TNS6, Q5NCN2, Q8JZT5, Q96DY5, Q9Z328
    Related
    ENSMUSP00000056464.8, ENSMUST00000054927.14
    Conserved Domains (2) summary
    cd01851
    Location:186 → 384
    GBP; Guanylate-binding protein (GBP) family (N-terminal domain)
    cd16538
    Location:78 → 125
    RING-HC_RNF112; RING finger, HC subclass, found in RING finger protein 112 (RNF112) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    61339243..61345014 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017314504.1 → XP_017169993.1  RING finger protein 112 isoform X6

    Conserved Domains (2) summary
    cd01851
    Location:185 → 383
    GBP; Guanylate-binding protein (GBP) family (N-terminal domain)
    cd16538
    Location:78 → 125
    RING-HC_RNF112; RING finger, HC subclass, found in RING finger protein 112 (RNF112) and similar proteins

  2. XM_006533180.2 → XP_006533243.1  RING finger protein 112 isoform X2

    Conserved Domains (2) summary
    cd16538
    Location:78 → 125
    RING-HC_RNF112; RING finger, HC subclass, found in RING finger protein 112 (RNF112) and similar proteins
    cl38936
    Location:185 → 408
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  3. XM_036156635.1 → XP_036012528.1  RING finger protein 112 isoform X4

    Conserved Domains (2) summary
    cd16538
    Location:55 → 102
    RING-HC_RNF112; RING finger, HC subclass, found in RING finger protein 112 (RNF112) and similar proteins
    cl38936
    Location:162 → 385
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  4. XM_006533183.2 → XP_006533246.1  RING finger protein 112 isoform X7

    See identical proteins and their annotated locations for XP_006533246.1

    UniProtKB/Swiss-Prot
    Q96DY5
    Conserved Domains (2) summary
    cd01851
    Location:163 → 361
    GBP; Guanylate-binding protein (GBP) family (N-terminal domain)
    cd16538
    Location:55 → 102
    RING-HC_RNF112; RING finger, HC subclass, found in RING finger protein 112 (RNF112) and similar proteins

  5. XM_006533181.2 → XP_006533244.1  RING finger protein 112 isoform X3

    Conserved Domains (2) summary
    cd16538
    Location:55 → 102
    RING-HC_RNF112; RING finger, HC subclass, found in RING finger protein 112 (RNF112) and similar proteins
    cl38936
    Location:163 → 386
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  6. XM_017314505.1 → XP_017169994.1  RING finger protein 112 isoform X9

    Conserved Domains (1) summary
    cd01851
    Location:50 → 248
    GBP; Guanylate-binding protein (GBP) family (N-terminal domain)

  7. XM_006533185.2 → XP_006533248.1  RING finger protein 112 isoform X8

    See identical proteins and their annotated locations for XP_006533248.1

    Conserved Domains (1) summary
    cl38936
    Location:50 → 273
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  8. XM_006533182.5 → XP_006533245.1  RING finger protein 112 isoform X5

    See identical proteins and their annotated locations for XP_006533245.1

    UniProtKB/Swiss-Prot
    Q3TNS6, Q5NCN2, Q8JZT5, Q96DY5, Q9Z328
    Conserved Domains (2) summary
    cd01851
    Location:186 → 384
    GBP; Guanylate-binding protein (GBP) family (N-terminal domain)
    cd16538
    Location:78 → 125
    RING-HC_RNF112; RING finger, HC subclass, found in RING finger protein 112 (RNF112) and similar proteins

  9. XM_006533178.2 → XP_006533241.1  RING finger protein 112 isoform X1

    See identical proteins and their annotated locations for XP_006533241.1

    UniProtKB/Swiss-Prot
    Q96DY5
    Conserved Domains (2) summary
    cd16538
    Location:78 → 125
    RING-HC_RNF112; RING finger, HC subclass, found in RING finger protein 112 (RNF112) and similar proteins
    cl38936
    Location:186 → 409
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  10. XM_030245933.1 → XP_030101793.1  RING finger protein 112 isoform X9

    Conserved Domains (1) summary
    cd01851
    Location:50 → 248
    GBP; Guanylate-binding protein (GBP) family (N-terminal domain)

  11. XM_006533184.2 → XP_006533247.1  RING finger protein 112 isoform X8

    See identical proteins and their annotated locations for XP_006533247.1

    Conserved Domains (1) summary
    cl38936
    Location:50 → 273
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  12. XM_036156636.1 → XP_036012529.1  RING finger protein 112 isoform X10

    Conserved Domains (1) summary
    cl38936
    Location:1 → 161
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96DY5.1 GenPept UniProtKB/Swiss-Prot:Q96DY5

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