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Zfp36 zinc finger protein 36 [ Mus musculus (house mouse) ]

Gene ID: 22695, updated on 16-Oct-2021

Summary

Official Symbol
Zfp36provided by MGI
Official Full Name
zinc finger protein 36provided by MGI
Primary source
MGI:MGI:99180
See related
Ensembl:ENSMUSG00000044786
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ttp; Gos24; TISII; Tis11; Nup475; TIS11D; Zfp-36
Expression
Broad expression in duodenum adult (RPKM 98.7), small intestine adult (RPKM 88.7) and 18 other tissues See more
Orthologs
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Genomic context

See Zfp36 in Genome Data Viewer
Location:
7 A3; 7 16.72 cM
Exon count:
2
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (28076209..28078653, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (28376784..28379228, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (29161803..29164247, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene snoRNA AF357399 Neighboring gene ribosomal protein S16 Neighboring gene pleckstrin homology domain containing, family G (with RhoGef domain) member 2 Neighboring gene nuclear encoded tRNA isoleucine 16 (anticodon TAT) Neighboring gene Paf1, RNA polymerase II complex component Neighboring gene mediator complex subunit 29 Neighboring gene sterile alpha motif domain containing 4B

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 14-3-3 protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables 14-3-3 protein binding ISO
Inferred from Sequence Orthology
more info
 
enables C-C chemokine binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA polymerase binding IDA
Inferred from Direct Assay
more info
PubMed 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables heat shock protein binding ISO
Inferred from Sequence Orthology
more info
 
enables mRNA 3'-UTR AU-rich region binding IDA
Inferred from Direct Assay
more info
PubMed 
enables mRNA 3'-UTR AU-rich region binding ISO
Inferred from Sequence Orthology
more info
 
enables mRNA 3'-UTR binding ISO
Inferred from Sequence Orthology
more info
 
enables mRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables mRNA binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in 3'-UTR-mediated mRNA destabilization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in 3'-UTR-mediated mRNA destabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in 3'-UTR-mediated mRNA destabilization ISO
Inferred from Sequence Orthology
more info
 
involved_in 3'-UTR-mediated mRNA stabilization ISO
Inferred from Sequence Orthology
more info
 
involved_in MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within RNA destabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to epidermal growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to fibroblast growth factor stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to fibroblast growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to glucocorticoid stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to granulocyte macrophage colony-stimulating factor stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to lipopolysaccharide IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to tumor necrosis factor IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to tumor necrosis factor ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within mRNA catabolic process ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in mRNA catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in mRNA transport ISO
Inferred from Sequence Orthology
more info
 
involved_in miRNA mediated inhibition of translation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of interleukin-2 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of myeloid cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of polynucleotide adenylyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of viral transcription ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IDA
Inferred from Direct Assay
more info
PubMed 
involved_in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay ISO
Inferred from Sequence Orthology
more info
 
involved_in nuclear-transcribed mRNA catabolic process, deadenylation-independent decay ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within nuclear-transcribed mRNA poly(A) tail shortening IDA
Inferred from Direct Assay
more info
PubMed 
involved_in nuclear-transcribed mRNA poly(A) tail shortening ISO
Inferred from Sequence Orthology
more info
 
involved_in p38MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of deadenylation-independent decapping of nuclear-transcribed mRNA ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of fat cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of gene silencing by miRNA ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of intracellular mRNA localization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mRNA catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of keratinocyte apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of keratinocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of keratinocyte proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of mRNA stability IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of mRNA stability IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of mRNA stability IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of mRNA stability ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in response to starvation ISO
Inferred from Sequence Orthology
more info
 
involved_in response to wounding IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to wounding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of CCR4-NOT complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in P-body ISO
Inferred from Sequence Orthology
more info
 
part_of RISC-loading complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic stress granule ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
PubMed 
part_of exosome (RNase complex) IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
mRNA decay activator protein ZFP36
Names
TPA-induced sequence 11
growth factor-inducible nuclear protein NUP475
tristetraprolin
tristetraproline

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011756.4NP_035886.1  mRNA decay activator protein ZFP36

    See identical proteins and their annotated locations for NP_035886.1

    Status: PROVISIONAL

    Source sequence(s)
    AC149606
    Consensus CDS
    CCDS21041.1
    UniProtKB/Swiss-Prot
    P22893
    UniProtKB/TrEMBL
    Q3U3D2
    Related
    ENSMUSP00000057815.6, ENSMUST00000051241.7
    Conserved Domains (1) summary
    pfam00642
    Location:96121
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    28076209..28078653 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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