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Plekhb2 pleckstrin homology domain containing, family B (evectins) member 2 [ Mus musculus (house mouse) ]

Gene ID: 226971, updated on 11-Apr-2024

Summary

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Official Symbol
Plekhb2provided by MGI
Official Full Name
pleckstrin homology domain containing, family B (evectins) member 2provided by MGI
Primary source
MGI:MGI:2385825
See related
Ensembl:ENSMUSG00000026123 AllianceGenome:MGI:2385825
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Evt2; Phdc; evt-2; 2310009M15Rik
Summary
Predicted to enable phosphatidylinositol-3,4,5-trisphosphate binding activity. Predicted to be involved in regulation of cell differentiation. Predicted to be located in endosome and membrane. Predicted to be integral component of membrane. Is expressed in gut. Orthologous to human PLEKHB2 (pleckstrin homology domain containing B2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in colon adult (RPKM 50.2), large intestine adult (RPKM 42.4) and 23 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 B; 1 13.34 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (34889040..34918666)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (34849959..34879585)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene Rho guanine nucleotide exchange factor 4 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:34859246-34859433 Neighboring gene small integral membrane protein 39 Neighboring gene family with sequence similarity 168, member B Neighboring gene STARR-seq mESC enhancer starr_00587 Neighboring gene STARR-positive B cell enhancer mm9_chr1:34924123-34924424 Neighboring gene uncharacterized protein C19orf29 homolog Neighboring gene STARR-seq mESC enhancer starr_00589 Neighboring gene STARR-seq mESC enhancer starr_00590 Neighboring gene charged multivesicular body protein 3 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Evectins: vesicular proteins that carry a pleckstrin homology domain and localize to post-Golgi membranes. Krappa R, et al. Proc Natl Acad Sci U S A, 1999 Apr 13. PMID 10200314, Free PMC Article
  2. Gene- and tissue-level interactions in normal gastrointestinal development and Hirschsprung disease. Chatterjee S, et al. Proc Natl Acad Sci U S A, 2019 Dec 26. PMID 31818953, Free PMC Article
  3. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables phosphatidylinositol-3,4,5-trisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in regulation of cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
pleckstrin homology domain-containing family B member 2
Names
PH domain-containing family B member 2
evectin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357425.1 → NP_001344354.1  pleckstrin homology domain-containing family B member 2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Both variants 1 and 3 encode the same isoform (1).
    Source sequence(s)
    AC107738
    Consensus CDS
    CCDS14874.1
    UniProtKB/Swiss-Prot
    Q3UDH6, Q8C4I4, Q8CA27, Q9QZC7
    Conserved Domains (2) summary
    cd13265
    Location:1 → 108
    PH_evt; Evectin Pleckstrin homology (PH) domain
    pfam11029
    Location:127 → 188
    DAZAP2; DAZ associated protein 2 (DAZAP2)

  2. NM_145516.2 → NP_663491.1  pleckstrin homology domain-containing family B member 2 isoform 1

    See identical proteins and their annotated locations for NP_663491.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1). Both variants 1 and 3 encode the same isoform.
    Source sequence(s)
    AK039771, AK149868, AV382273, CK625615
    Consensus CDS
    CCDS14874.1
    UniProtKB/Swiss-Prot
    Q3UDH6, Q8C4I4, Q8CA27, Q9QZC7
    Related
    ENSMUSP00000027297.5, ENSMUST00000027297.11
    Conserved Domains (2) summary
    cd13265
    Location:1 → 108
    PH_evt; Evectin Pleckstrin homology (PH) domain
    pfam11029
    Location:127 → 188
    DAZAP2; DAZ associated protein 2 (DAZAP2)

  3. NM_175421.1 → NP_780630.1  pleckstrin homology domain-containing family B member 2 isoform 2

    See identical proteins and their annotated locations for NP_780630.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and has multiple coding region differences, compared to variant 1. The resulting protein (isoform 2) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC107738
    Consensus CDS
    CCDS78558.1
    UniProtKB/TrEMBL
    Q3UFC9
    Related
    ENSMUSP00000140475.2, ENSMUST00000156687.8
    Conserved Domains (2) summary
    cd13265
    Location:1 → 108
    PH_evt; Evectin Pleckstrin homology (PH) domain
    pfam00169
    Location:4 → 100
    PH; PH domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    34889040..34918666
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006495898.3 → XP_006495961.1  pleckstrin homology domain-containing family B member 2 isoform X1

    See identical proteins and their annotated locations for XP_006495961.1

    UniProtKB/Swiss-Prot
    Q3UDH6, Q8C4I4, Q8CA27, Q9QZC7
    Conserved Domains (2) summary
    cd13265
    Location:1 → 108
    PH_evt; Evectin Pleckstrin homology (PH) domain
    pfam11029
    Location:127 → 188
    DAZAP2; DAZ associated protein 2 (DAZAP2)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QZC7.1 GenPept UniProtKB/Swiss-Prot:Q9QZC7

Gene LinkOut

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