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Hibch 3-hydroxyisobutyryl-Coenzyme A hydrolase [ Mus musculus (house mouse) ]

Gene ID: 227095, updated on 25-Jan-2022

Summary

Official Symbol
Hibchprovided by MGI
Official Full Name
3-hydroxyisobutyryl-Coenzyme A hydrolaseprovided by MGI
Primary source
MGI:MGI:1923792
See related
Ensembl:ENSMUSG00000041426 AllianceGenome:MGI:1923792
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HIBYL-COA-H; 2610509I15Rik
Summary
Predicted to enable 3-hydroxyisobutyryl-CoA hydrolase activity. Predicted to be involved in valine catabolic process. Predicted to act upstream of or within branched-chain amino acid catabolic process. Located in mitochondrion. Orthologous to human HIBCH (3-hydroxyisobutyryl-CoA hydrolase). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Ubiquitous expression in subcutaneous fat pad adult (RPKM 20.4), heart adult (RPKM 15.5) and 28 other tissues See more
Orthologs
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Genomic context

See Hibch in Genome Data Viewer
Location:
1; 1 C1.1
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (52884197..52960145)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (52845038..52920986)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (52901890..52977704)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene major facilitator superfamily domain containing 6 Neighboring gene inositol polyphosphate-1-phosphatase Neighboring gene heat shock protein 90, alpha (cytosolic), class A member 1 pseudogene Neighboring gene RIKEN cDNA 1700019D03 gene Neighboring gene myostatin

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC31364

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3-hydroxyisobutyryl-CoA hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables 3-hydroxyisobutyryl-CoA hydrolase activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within branched-chain amino acid catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in valine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
3-hydroxyisobutyryl-CoA hydrolase, mitochondrial
Names
HIB-CoA hydrolase
NP_666220.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_146108.2NP_666220.1  3-hydroxyisobutyryl-CoA hydrolase, mitochondrial precursor

    See identical proteins and their annotated locations for NP_666220.1

    Status: VALIDATED

    Source sequence(s)
    AC110177, AK076038, AK082965
    Consensus CDS
    CCDS14948.1
    UniProtKB/Swiss-Prot
    Q8QZS1
    Related
    ENSMUSP00000045606.7, ENSMUST00000044478.7
    Conserved Domains (2) summary
    PRK05617
    Location:33377
    PRK05617; 3-hydroxyisobutyryl-CoA hydrolase; Provisional
    pfam16113
    Location:46374
    ECH_2; Enoyl-CoA hydratase/isomerase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    52884197..52960145
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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