U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Hibch 3-hydroxyisobutyryl-Coenzyme A hydrolase [ Mus musculus (house mouse) ]

Gene ID: 227095, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Hibchprovided by MGI
Official Full Name
3-hydroxyisobutyryl-Coenzyme A hydrolaseprovided by MGI
Primary source
MGI:MGI:1923792
See related
Ensembl:ENSMUSG00000041426 AllianceGenome:MGI:1923792
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HIBYL-COA-H; 2610509I15Rik
Summary
Predicted to enable 3-hydroxyisobutyryl-CoA hydrolase activity. Predicted to be involved in valine catabolic process. Predicted to act upstream of or within branched-chain amino acid catabolic process. Located in mitochondrion. Orthologous to human HIBCH (3-hydroxyisobutyryl-CoA hydrolase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in subcutaneous fat pad adult (RPKM 20.4), heart adult (RPKM 15.5) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
1 C1.1; 1 26.99 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (52884197..52960145)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (52845038..52920986)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene major facilitator superfamily domain containing 6 Neighboring gene STARR-seq mESC enhancer starr_00904 Neighboring gene STARR-positive B cell enhancer ABC_E3274 Neighboring gene STARR-positive B cell enhancer ABC_E1543 Neighboring gene inositol polyphosphate-1-phosphatase Neighboring gene STARR-positive B cell enhancer ABC_E3275 Neighboring gene STARR-seq mESC enhancer starr_00905 Neighboring gene heat shock protein 90, alpha (cytosolic), class A member 1 pseudogene Neighboring gene RIKEN cDNA 1700019D03 gene Neighboring gene STARR-seq mESC enhancer starr_00906 Neighboring gene STARR-seq mESC enhancer starr_00907 Neighboring gene myostatin

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Epigenetic functions of smchd1 repress gene clusters on the inactive X chromosome and on autosomes. Gendrel AV, et al. Mol Cell Biol, 2013 Aug. PMID 23754746, Free PMC Article
  2. Interactome Analysis Reveals Regulator of G Protein Signaling 14 (RGS14) is a Novel Calcium/Calmodulin (Ca(2+)/CaM) and CaM Kinase II (CaMKII) Binding Partner. Evans PR, et al. J Proteome Res, 2018 Apr 6. PMID 29518331, Free PMC Article
  3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC31364

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3-hydroxyisobutyryl-CoA hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3-hydroxyisobutyryl-CoA hydrolase activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within branched-chain amino acid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in valine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
3-hydroxyisobutyryl-CoA hydrolase, mitochondrial
Names
HIB-CoA hydrolase
NP_666220.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_146108.2 → NP_666220.1  3-hydroxyisobutyryl-CoA hydrolase, mitochondrial precursor

    See identical proteins and their annotated locations for NP_666220.1

    Status: VALIDATED

    Source sequence(s)
    AC110177, AK076038, AK082965
    Consensus CDS
    CCDS14948.1
    UniProtKB/Swiss-Prot
    Q8QZS1
    Related
    ENSMUSP00000045606.7, ENSMUST00000044478.7
    Conserved Domains (2) summary
    PRK05617
    Location:33 → 377
    PRK05617; 3-hydroxyisobutyryl-CoA hydrolase; Provisional
    pfam16113
    Location:46 → 374
    ECH_2; Enoyl-CoA hydratase/isomerase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    52884197..52960145
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8QZS1.1 GenPept UniProtKB/Swiss-Prot:Q8QZS1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous