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Zfp59 zinc finger protein 59 [ Mus musculus (house mouse) ]

Gene ID: 22717, updated on 11-Apr-2024

Summary

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Official Symbol
Zfp59provided by MGI
Official Full Name
zinc finger protein 59provided by MGI
Primary source
MGI:MGI:99206
See related
Ensembl:ENSMUSG00000078779 AllianceGenome:MGI:99206
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mfg2; Mfg-2
Summary
The Krueppel-associated box (KRAB) is a domain of around 75 amino acids found in the N-terminal portion of about one third of eukaryotic Krueppel-type C2H2 zinc finger proteins (ZFPs). The KRAB domain functions as a transcriptional repressor when tethered to the template DNA by a DNA-binding domain. Although the function of KRAB-ZFPs is largely unknown, they appear to play important roles during cell differentiation and development. This gene encodes a protein belonging to the Krueppel family of C2H2-type zinc finger proteins and has been shown to accumulate in the nuclei of mature sperm in association with the nuclear matrix. [provided by RefSeq, Jul 2008]
Expression
Broad expression in CNS E11.5 (RPKM 2.2), CNS E18 (RPKM 2.2) and 24 other tissues See more
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Genomic context

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Location:
7 A3; 7 15.97 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (27535471..27556218)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (27836046..27856793)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 29810 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:28589770-28589879 Neighboring gene zinc finger protein 626 Neighboring gene STARR-seq mESC enhancer starr_18392 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:28645358-28645700 Neighboring gene zinc finger protein 607A Neighboring gene STARR-seq mESC enhancer starr_18395 Neighboring gene protein kinase C, zeta 2 Neighboring gene zinc finger protein 974 Neighboring gene predicted gene, 26891

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The product of Zfp59 (Mfg2), a mouse gene expressed at the spermatid stage of spermatogenesis, accumulates in spermatozoa nuclei. Passananti C, et al. Cell Growth Differ, 1995 Aug. PMID 8547218
  2. Biochemical analysis of the Kruppel-associated box (KRAB) transcriptional repression domain. Peng H, et al. J Biol Chem, 2000 Jun 16. PMID 10748030
  3. Mouse genes coding for "zinc-finger"-containing proteins: characterization and expression in differentiated cells. Passananti C, et al. Proc Natl Acad Sci U S A, 1989 Dec. PMID 2512579, Free PMC Article
  4. A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. Wiese CB, et al. Front Neurosci, 2012. PMID 22988430, Free PMC Article
  5. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in male germ cell nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 59
Names
zfp-59
zinc finger protein Mfg-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011762.4 → NP_035892.2  zinc finger protein 59

    See identical proteins and their annotated locations for NP_035892.2

    Status: VALIDATED

    Source sequence(s)
    AC139063, AC164532
    Consensus CDS
    CCDS39851.1
    UniProtKB/Swiss-Prot
    F8VPX4, P16373, Q61849
    Related
    ENSMUSP00000145671.2, ENSMUST00000205701.2
    Conserved Domains (3) summary
    smart00349
    Location:14 → 75
    KRAB; krueppel associated box
    COG5048
    Location:167 → 554
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:286 → 306
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    27535471..27556218
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030242394.1 → XP_030098254.1  zinc finger protein 59 isoform X1

    UniProtKB/Swiss-Prot
    F8VPX4, P16373, Q61849
    Conserved Domains (3) summary
    smart00349
    Location:14 → 75
    KRAB; krueppel associated box
    COG5048
    Location:167 → 554
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:286 → 306
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. XM_030242396.1 → XP_030098256.1  zinc finger protein 59 isoform X2

    Conserved Domains (3) summary
    COG5048
    Location:125 → 512
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:244 → 264
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02581
    Location:1 → 33
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

  3. XM_030242397.2 → XP_030098257.1  zinc finger protein 59 isoform X3

    Conserved Domains (2) summary
    COG5048
    Location:93 → 480
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:212 → 232
    ZF_C2H2; C2H2 Zn finger [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P16373.3 GenPept UniProtKB/Swiss-Prot:P16373

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