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Farp2 FERM, RhoGEF and pleckstrin domain protein 2 [ Mus musculus (house mouse) ]

Gene ID: 227377, updated on 25-Jan-2022

Summary

Official Symbol
Farp2provided by MGI
Official Full Name
FERM, RhoGEF and pleckstrin domain protein 2provided by MGI
Primary source
MGI:MGI:2385126
See related
Ensembl:ENSMUSG00000034066 AllianceGenome:MGI:2385126
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fir; AI465173; BC009153; mKIAA0793; D030026M03Rik
Summary
Enables guanyl-nucleotide exchange factor activity. Involved in several processes, including actin cytoskeleton reorganization; osteoclast differentiation; and podosome assembly. Acts upstream of or within hair cycle process. Predicted to be located in cytoplasm. Is expressed in central nervous system and retina. Orthologous to human FARP2 (FERM, ARH/RhoGEF and pleckstrin domain protein 2). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Ubiquitous expression in large intestine adult (RPKM 5.0), colon adult (RPKM 4.4) and 28 other tissues See more
Orthologs
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Genomic context

See Farp2 in Genome Data Viewer
Location:
1; 1 D
Exon count:
27
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (93439826..93549698)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (93512104..93621976)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (95408681..95518553)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene high density lipoprotein (HDL) binding protein Neighboring gene predicted gene, 17415 Neighboring gene septin 2 Neighboring gene predicted gene, 41920 Neighboring gene elongation factor RNA polymerase II-like 3 pseudogene Neighboring gene serine/threonine kinase 25 (yeast) Neighboring gene BCL2-related ovarian killer Neighboring gene THAP domain containing 4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0793

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytoskeletal protein binding IEA
Inferred from Electronic Annotation
more info
 
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables guanyl-nucleotide exchange factor activity TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
FERM, ARHGEF and pleckstrin domain-containing protein 2
Names
FERM domain including RhoGEF
FERM, RhoGEF and pleckstrin domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145519.2NP_663494.2  FERM, ARHGEF and pleckstrin domain-containing protein 2

    See identical proteins and their annotated locations for NP_663494.2

    Status: VALIDATED

    Source sequence(s)
    AK050860, AK173028, AW912106, BB663505, BI739824, BP770314, BY130680
    Consensus CDS
    CCDS15191.1
    UniProtKB/Swiss-Prot
    Q91VS8
    Related
    ENSMUSP00000112725.2, ENSMUST00000120301.8
    Conserved Domains (9) summary
    smart00295
    Location:45234
    B41; Band 4.1 homologues
    cd00160
    Location:540723
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01220
    Location:752859
    PH1_FARP1-like; FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins Pleckstrin Homology (PH) domain, repeat 1
    cd13193
    Location:221341
    FERM_C_FARP1-like; FERM domain C-lobe of FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins
    cd13235
    Location:9291026
    PH2_FARP1-like; FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins Pleckstrin Homology (PH) domain, repeat 2
    pfam00169
    Location:9341027
    PH; PH domain
    pfam00373
    Location:131234
    FERM_M; FERM central domain
    pfam08736
    Location:333375
    FA; FERM adjacent (FA)
    pfam09379
    Location:48111
    FERM_N; FERM N-terminal domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    93439826..93549698
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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