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Zfp85 zinc finger protein 85 [ Mus musculus (house mouse) ]

Gene ID: 22746, updated on 8-Feb-2024

Summary

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Official Symbol
Zfp85provided by MGI
Official Full Name
zinc finger protein 85provided by MGI
Primary source
MGI:MGI:107767
See related
Ensembl:ENSMUSG00000058331 AllianceGenome:MGI:107767
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Zfp71; KRAB19; Rslcan2; Zfp85-rs1
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human ZNF355P (zinc finger protein 355, pseudogene) and ZNF429 (zinc finger protein 429). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E14 (RPKM 2.0), CNS E18 (RPKM 1.9) and 22 other tissues See more
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Genomic context

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See Zfp85 in Genome Data Viewer
Location:
13 B3; 13 34.74 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (67892583..67903321, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (67744464..67755202, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 738 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:67784456-67784643 Neighboring gene zinc finger protein 65 Neighboring gene STARR-seq mESC enhancer starr_34907 Neighboring gene zinc finger protein 85, opposite strand Neighboring gene STARR-seq mESC enhancer starr_34908 Neighboring gene STARR-seq mESC enhancer starr_34909 Neighboring gene STARR-seq mESC enhancer starr_34910 Neighboring gene zinc finger protein 85, related sequence 1 pseudogene Neighboring gene zinc finger protein 493

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Emergence of the ZNF91 Krüppel-associated box-containing zinc finger gene family in the last common ancestor of anthropoidea. Bellefroid EJ, et al. Proc Natl Acad Sci U S A, 1995 Nov 7. PMID 7479878, Free PMC Article
  2. Activation of the c-H-ras proto-oncogene by retrovirus insertion and chromosomal rearrangement in a Moloney leukemia virus-induced T-cell leukemia. Ihle JN, et al. J Virol, 1989 Jul. PMID 2542606, Free PMC Article
  3. Regulator of sex-limitation (Rsl) encodes a pair of KRAB zinc-finger genes that control sexually dimorphic liver gene expression. Krebs CJ, et al. Genes Dev, 2003 Nov 1. PMID 14563677, Free PMC Article
  4. Chromosomal location of fifteen unique mouse KRAB-containing zinc finger loci. Marine JC, et al. Mamm Genome, 1996 Jun. PMID 8662221
  5. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 85
Names
KRAB-zinc finger protein 71
regulator of sex-limitation candidate 2
zinc finger protein 85, related sequence 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001130.3 → NP_001001130.1  zinc finger protein 85

    See identical proteins and their annotated locations for NP_001001130.1

    Status: VALIDATED

    Source sequence(s)
    BC055337, BK001637, DV658296
    Consensus CDS
    CCDS36717.1
    UniProtKB/TrEMBL
    B8JJY3, Q7TMC9
    Related
    ENSMUSP00000121202.3, ENSMUST00000144183.3
    Conserved Domains (5) summary
    smart00349
    Location:5 → 65
    KRAB; krueppel associated box
    COG5048
    Location:79 → 464
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:83 → 103
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:5 → 44
    KRAB; KRAB box
    pfam13465
    Location:375 → 400
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    67892583..67903321 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247245.2 → XP_030103105.1  zinc finger protein 85 isoform X2

    Conserved Domains (3) summary
    COG5048
    Location:74 → 439
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:50 → 70
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02581
    Location:1 → 32
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

  2. XM_036158035.1 → XP_036013928.1  zinc finger protein 85 isoform X1

    Conserved Domains (3) summary
    smart00349
    Location:45 → 90
    KRAB; krueppel associated box
    COG5048
    Location:115 → 480
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:91 → 111
    ZF_C2H2; C2H2 Zn finger [structural motif]
Nucleotide Protein Strain
Heading Accession and Version

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