Uap1l1 UDP-N-acteylglucosamine pyrophosphorylase 1-like 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Uap1l1provided by MGI
Official Full Name: UDP-N-acteylglucosamine pyrophosphorylase 1-like 1provided by MGI
Primary source: MGI:MGI:2443318
See related: Ensembl:ENSMUSG00000026956 AllianceGenome:MGI:2443318
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 5730445F03Rik
Summary: Predicted to enable UDP-N-acetylglucosamine diphosphorylase activity. Predicted to be involved in UDP-N-acetylglucosamine biosynthetic process. Orthologous to human UAP1L1 (UDP-N-acetylglucosamine pyrophosphorylase 1 like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in placenta adult (RPKM 65.1), duodenum adult (RPKM 59.5) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 A3; 2 17.19 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (25251501..25255695, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (25361489..25365682, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Uap1l1 is upregulated in the liver of young MKO-hep mice without any macroscopically detectable tumor nodules and is prominently expressed in the hepatic tumors developed in the aged MKO-hep mice.
Title: Identification of UAP1L1 as a critical factor for protein O-GlcNAcylation and cell proliferation in human hepatoma cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (1) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables UDP-N-acetylglucosamine diphosphorylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables nucleotidyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables uridylyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in UDP-N-acetylglucosamine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: UDP-N-acetylhexosamine pyrophosphorylase-like protein 1

NP_001028465.1

EC 2.7.7.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033293.3 → NP_001028465.1 UDP-N-acetylhexosamine pyrophosphorylase-like protein 1

See identical proteins and their annotated locations for NP_001028465.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the protein-coding transcript.

Source sequence(s)

AK159787, AL732557, BE944661, BY096323

Consensus CDS

CCDS15767.1

UniProtKB/Swiss-Prot

A1L3D3, Q3TW96, Q6KAP8, Q6NVB6, Q80XP4

UniProtKB/TrEMBL

Q8BVK3

Related

ENSMUSP00000099989.4, ENSMUST00000102925.4

Conserved Domains (1) summary

cd04193
Location:92 → 413

UDPGlcNAc_PPase; UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc

RNA

NR_149315.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice junction compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AK131159, BE944661, BY096323