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Zfr zinc finger RNA binding protein [ Mus musculus (house mouse) ]

Gene ID: 22763, updated on 5-Mar-2024

Summary

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Official Symbol
Zfrprovided by MGI
Official Full Name
zinc finger RNA binding proteinprovided by MGI
Primary source
MGI:MGI:1341890
See related
Ensembl:ENSMUSG00000022201 AllianceGenome:MGI:1341890
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C920030H05Rik
Summary
Predicted to enable double-stranded RNA binding activity and single-stranded RNA binding activity. Predicted to be located in chromosome; cytoplasm; and nucleus. Is expressed in several structures, including early conceptus; genitourinary system; nervous system; submandibular gland primordium; and vibrissa. Orthologous to human ZFR (zinc finger RNA binding protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in frontal lobe adult (RPKM 32.5), cortex adult (RPKM 29.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Zfr in Genome Data Viewer
Location:
15 A1; 15 5.9 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (12117649..12185535)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (12117563..12185449)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_38007 Neighboring gene predicted gene 2559 Neighboring gene predicted gene, 34759 Neighboring gene microRNA 1898 Neighboring gene predicted gene 2573 Neighboring gene STARR-positive B cell enhancer ABC_E2438 Neighboring gene ribosomal protein S29 pseudogene Neighboring gene myotubularin related protein 12 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:12160369-12160618

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Requirement for the murine zinc finger protein ZFR in perigastrulation growth and survival. Meagher MJ, et al. Mol Cell Biol, 2001 Apr. PMID 11283266, Free PMC Article
  2. ZFR promotes cell proliferation and tumor development in colorectal and liver cancers. Long Y, et al. Biochem Biophys Res Commun, 2019 Jun 11. PMID 31010678
  3. Early developmental expression of Mus musculus zinc finger RNA-binding protein compared to orthologs in Caenorhabditis elegans and Danio rerio and subcellular localization of Mus musculus and Caenorhabditis elegans zinc finger RNA-binding protein in 2-cell Mus musculus embryos. Doğanlı C, et al. DNA Cell Biol, 2010 Dec. PMID 21091219
  4. Cloning and expression of the human single copy homologue of the mouse zinc finger protein zfr. Kleines M, et al. Gene, 2001 Sep 5. PMID 11574164
  5. Identification of ZFR, an ancient and highly conserved murine chromosome-associated zinc finger protein. Meagher MJ, et al. Gene, 1999 Mar 4. PMID 10072773

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ZFR overexpression also promoted tumor development of immortalized mouse liver cells.
    Title: ZFR promotes cell proliferation and tumor development in colorectal and liver cancers.
  2. Mouse Zfr mRNA was detected in all stages tested during mouse preimplantation, with higher levels at the 1-cell stage that includes the maternal contribution of Zfr mRNA.
    Title: Early developmental expression of Mus musculus zinc finger RNA-binding protein compared to orthologs in Caenorhabditis elegans and Danio rerio and subcellular localization of Mus musculus and Caenorhabditis elegans zinc finger RNA-binding protein in 2-cell Mus musculus embryos.
  3. ZFR is a native component of Staufen2-containing granules and likely plays its role during early steps of RNA transport and localization
    Title: The zinc-finger protein ZFR is critical for Staufen 2 isoform specific nucleocytoplasmic shuttling in neurons.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC176100

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables double-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables single-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger RNA-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001358823.1 → NP_001345752.1  zinc finger RNA-binding protein isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC161269
    UniProtKB/TrEMBL
    B2RUG7
    Conserved Domains (3) summary
    smart00572
    Location:720 → 974
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    smart00451
    Location:517 → 548
    ZnF_U1; U1-like zinc finger
    sd00020
    Location:520 → 542
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_011767.2 → NP_035897.2  zinc finger RNA-binding protein isoform 1

    See identical proteins and their annotated locations for NP_035897.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AF071059, AK034963, AK041429, BC058570, BU757317
    Consensus CDS
    CCDS37044.2
    UniProtKB/Swiss-Prot
    O88532, Q3TY30, Q8BS85, Q8CGG5, Q91VZ0, Q9CT34
    UniProtKB/TrEMBL
    B2RUG7
    Related
    ENSMUSP00000118911.2, ENSMUST00000122941.8
    Conserved Domains (4) summary
    smart00572
    Location:784 → 1038
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    PHA03255
    Location:382 → 551
    PHA03255; BDLF3; Provisional
    smart00451
    Location:581 → 612
    ZnF_U1; U1-like zinc finger
    sd00020
    Location:584 → 606
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    12117649..12185535
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520057.2 → XP_006520120.1  zinc finger RNA-binding protein isoform X1

    UniProtKB/TrEMBL
    B2RUG7
    Conserved Domains (4) summary
    smart00572
    Location:792 → 1046
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    PHA03255
    Location:390 → 559
    PHA03255; BDLF3; Provisional
    smart00451
    Location:589 → 620
    ZnF_U1; U1-like zinc finger
    sd00020
    Location:341 → 363
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. XM_006520059.3 → XP_006520122.1  zinc finger RNA-binding protein isoform X5

    UniProtKB/TrEMBL
    B2RUG7
    Conserved Domains (3) summary
    smart00572
    Location:728 → 982
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    smart00451
    Location:525 → 556
    ZnF_U1; U1-like zinc finger
    sd00020
    Location:528 → 550
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. XM_030248530.1 → XP_030104390.1  zinc finger RNA-binding protein isoform X3

    UniProtKB/TrEMBL
    B2RUG7
    Conserved Domains (4) summary
    smart00572
    Location:772 → 1026
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    PHA03255
    Location:370 → 539
    PHA03255; BDLF3; Provisional
    smart00451
    Location:569 → 600
    ZnF_U1; U1-like zinc finger
    sd00020
    Location:321 → 343
    ZF_C2H2; C2H2 Zn finger [structural motif]

  4. XM_036159388.1 → XP_036015281.1  zinc finger RNA-binding protein isoform X6

    UniProtKB/TrEMBL
    B2RUG7
    Conserved Domains (3) summary
    smart00572
    Location:708 → 962
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    smart00451
    Location:505 → 536
    ZnF_U1; U1-like zinc finger
    sd00020
    Location:508 → 530
    ZF_C2H2; C2H2 Zn finger [structural motif]

  5. XM_006520058.4 → XP_006520121.1  zinc finger RNA-binding protein isoform X2

    UniProtKB/TrEMBL
    B2RUG7
    Conserved Domains (4) summary
    smart00572
    Location:780 → 1034
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    PHA03255
    Location:378 → 547
    PHA03255; BDLF3; Provisional
    smart00451
    Location:577 → 608
    ZnF_U1; U1-like zinc finger
    sd00020
    Location:329 → 351
    ZF_C2H2; C2H2 Zn finger [structural motif]

  6. XM_017316588.1 → XP_017172077.1  zinc finger RNA-binding protein isoform X4

    UniProtKB/TrEMBL
    B2RUG7
    Conserved Domains (4) summary
    smart00572
    Location:740 → 994
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    PHA03255
    Location:338 → 507
    PHA03255; BDLF3; Provisional
    smart00451
    Location:537 → 568
    ZnF_U1; U1-like zinc finger
    sd00020
    Location:289 → 311
    ZF_C2H2; C2H2 Zn finger [structural motif]

RNA

  1. XR_001781521.2 RNA Sequence

  2. XR_001781520.3 RNA Sequence

  3. XR_001781522.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O88532.2 GenPept UniProtKB/Swiss-Prot:O88532

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