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Snapc4 small nuclear RNA activating complex, polypeptide 4 [ Mus musculus (house mouse) ]

Gene ID: 227644, updated on 21-Apr-2024

Summary

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Official Symbol
Snapc4provided by MGI
Official Full Name
small nuclear RNA activating complex, polypeptide 4provided by MGI
Primary source
MGI:MGI:2443935
See related
Ensembl:ENSMUSG00000036281 AllianceGenome:MGI:2443935
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
5730436L13Rik
Summary
Predicted to enable DNA binding activity; RNA polymerase II general transcription initiation factor activity; and RNA polymerase III general transcription initiation factor activity. Predicted to be involved in snRNA transcription by RNA polymerase II and snRNA transcription by RNA polymerase III. Predicted to be located in nucleus. Predicted to be part of snRNA-activating protein complex. Is expressed in early conceptus and genitourinary system. Orthologous to human SNAPC4 (small nuclear RNA activating complex polypeptide 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 8.1), genital fat pad adult (RPKM 7.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 A3; 2 18.87 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (26252777..26270666, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (26362765..26380661, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene G-protein signalling modulator 1 (AGS3-like, C. elegans) Neighboring gene DNL-type zinc finger Neighboring gene predicted gene 13562 Neighboring gene caspase recruitment domain family, member 9 Neighboring gene endosome associated trafficking regulator 1 Neighboring gene peptidase (mitochondrial processing) alpha Neighboring gene inositol polyphosphate-5-phosphatase E Neighboring gene STARR-positive B cell enhancer ABC_E5900

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A collection of cDNAs enriched in upper cortical layers of the embryonic mouse brain. García-Frigola C, et al. Brain Res Mol Brain Res, 2004 Mar 30. PMID 15010206
  2. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
  3. An atlas of combinatorial transcriptional regulation in mouse and man. Ravasi T, et al. Cell, 2010 Mar 5. PMID 20211142, Free PMC Article
  4. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
  5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC59524

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
contributes_to RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II general transcription initiation factor activity ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase III general transcription initiation factor activity ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase III type 3 promoter sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in snRNA transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in snRNA transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in snRNA transcription by RNA polymerase III IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in snRNA transcription by RNA polymerase III ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of snRNA-activating protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of snRNA-activating protein complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
snRNA-activating protein complex subunit 4
Names
SNAPc subunit 4
snRNA-activating protein complex 190 kDa subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290419.2 → NP_001277348.1  snRNA-activating protein complex subunit 4 isoform b

    See identical proteins and their annotated locations for NP_001277348.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes an additional exon in the 5' region, and it thus differs in its 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AL732541
    UniProtKB/TrEMBL
    A2AIV6
    Related
    ENSMUST00000149850.8
    Conserved Domains (5) summary
    smart00717
    Location:311 → 358
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd00167
    Location:365 → 406
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    pfam13921
    Location:314 → 374
    Myb_DNA-bind_6; Myb-like DNA-binding domain
    cl09111
    Location:110 → 162
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
    cl21498
    Location:172 → 215
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

  2. NM_001406731.1 → NP_001393660.1  snRNA-activating protein complex subunit 4 3

    Status: VALIDATED

    Source sequence(s)
    AL732541
    UniProtKB/Swiss-Prot
    Q6PGG7, Q80UG9, Q810L1, Q8BP86

  3. NM_001406732.1 → NP_001393661.1  snRNA-activating protein complex subunit 4 3

    Status: VALIDATED

    Source sequence(s)
    AL732541
    UniProtKB/Swiss-Prot
    Q6PGG7, Q80UG9, Q810L1, Q8BP86

  4. NM_001406733.1 → NP_001393662.1  snRNA-activating protein complex subunit 4 isoform a

    Status: VALIDATED

    Source sequence(s)
    AL732541

  5. NM_001406734.1 → NP_001393663.1  snRNA-activating protein complex subunit 4 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL732541

  6. NM_001406735.1 → NP_001393664.1  snRNA-activating protein complex subunit 4 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL732541

  7. NM_001406736.1 → NP_001393665.1  snRNA-activating protein complex subunit 4 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL732541

  8. NM_001406737.1 → NP_001393666.1  snRNA-activating protein complex subunit 4 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL732541

  9. NM_001406738.1 → NP_001393667.1  snRNA-activating protein complex subunit 4 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL732541

  10. NM_001406739.1 → NP_001393668.1  snRNA-activating protein complex subunit 4 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL732541

  11. NM_172339.5 → NP_758842.1  snRNA-activating protein complex subunit 4 isoform a

    See identical proteins and their annotated locations for NP_758842.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (a).
    Source sequence(s)
    AL732541
    Consensus CDS
    CCDS15802.1
    UniProtKB/TrEMBL
    A2AIV6
    Related
    ENSMUSP00000041767.5, ENSMUST00000035427.11
    Conserved Domains (5) summary
    smart00717
    Location:401 → 448
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd00167
    Location:455 → 496
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    pfam13921
    Location:404 → 464
    Myb_DNA-bind_6; Myb-like DNA-binding domain
    cl09111
    Location:200 → 252
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
    cl21498
    Location:262 → 305
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    26252777..26270666 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011239065.4 → XP_011237367.1  snRNA-activating protein complex subunit 4 isoform X2

    UniProtKB/TrEMBL
    A2AIV6
    Conserved Domains (4) summary
    smart00717
    Location:461 → 504
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    PHA03247
    Location:815 → 1174
    PHA03247; large tegument protein UL36; Provisional
    COG5147
    Location:200 → 407
    REB1; Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning]
    pfam13921
    Location:412 → 472
    Myb_DNA-bind_6; Myb-like DNA-binding domain

  2. XM_011239064.4 → XP_011237366.1  snRNA-activating protein complex subunit 4 isoform X1

    UniProtKB/TrEMBL
    A2AIV6
    Conserved Domains (4) summary
    smart00717
    Location:461 → 504
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    PHA03247
    Location:815 → 1174
    PHA03247; large tegument protein UL36; Provisional
    COG5147
    Location:200 → 407
    REB1; Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning]
    pfam13921
    Location:412 → 472
    Myb_DNA-bind_6; Myb-like DNA-binding domain

  3. XM_036160757.1 → XP_036016650.1  snRNA-activating protein complex subunit 4 isoform X14

    Conserved Domains (1) summary
    PHA03247
    Location:124 → 494
    PHA03247; large tegument protein UL36; Provisional

  4. XM_030249765.2 → XP_030105625.1  snRNA-activating protein complex subunit 4 isoform X14

    Conserved Domains (1) summary
    PHA03247
    Location:124 → 494
    PHA03247; large tegument protein UL36; Provisional

  5. XM_036160749.1 → XP_036016642.1  snRNA-activating protein complex subunit 4 isoform X10

    UniProtKB/TrEMBL
    A2AIV6
    Conserved Domains (4) summary
    smart00717
    Location:301 → 344
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    PHA03247
    Location:634 → 993
    PHA03247; large tegument protein UL36; Provisional
    COG5147
    Location:2 → 284
    REB1; Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning]
    pfam13921
    Location:252 → 312
    Myb_DNA-bind_6; Myb-like DNA-binding domain

  6. XM_030249744.2 → XP_030105604.1  snRNA-activating protein complex subunit 4 isoform X7

    UniProtKB/TrEMBL
    A2AIV6
    Conserved Domains (4) summary
    smart00717
    Location:363 → 406
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    PHA03247
    Location:696 → 1055
    PHA03247; large tegument protein UL36; Provisional
    COG5147
    Location:102 → 309
    REB1; Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning]
    pfam13921
    Location:314 → 374
    Myb_DNA-bind_6; Myb-like DNA-binding domain

  7. XM_030249743.2 → XP_030105603.1  snRNA-activating protein complex subunit 4 isoform X6

    UniProtKB/TrEMBL
    A2AIV6
    Conserved Domains (4) summary
    smart00717
    Location:363 → 406
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    PHA03247
    Location:717 → 1076
    PHA03247; large tegument protein UL36; Provisional
    COG5147
    Location:102 → 309
    REB1; Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning]
    pfam13921
    Location:314 → 374
    Myb_DNA-bind_6; Myb-like DNA-binding domain

  8. XM_036160748.1 → XP_036016641.1  snRNA-activating protein complex subunit 4 isoform X9

    UniProtKB/TrEMBL
    A2AIV6
    Conserved Domains (4) summary
    smart00717
    Location:301 → 344
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    PHA03247
    Location:655 → 1014
    PHA03247; large tegument protein UL36; Provisional
    COG5147
    Location:2 → 284
    REB1; Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning]
    pfam13921
    Location:252 → 312
    Myb_DNA-bind_6; Myb-like DNA-binding domain

  9. XM_011239066.4 → XP_011237368.1  snRNA-activating protein complex subunit 4 isoform X3

    UniProtKB/TrEMBL
    A2AIV6
    Conserved Domains (4) summary
    smart00717
    Location:453 → 496
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    PHA03247
    Location:807 → 1166
    PHA03247; large tegument protein UL36; Provisional
    COG5147
    Location:192 → 399
    REB1; Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning]
    pfam13921
    Location:404 → 464
    Myb_DNA-bind_6; Myb-like DNA-binding domain

  10. XM_036160746.1 → XP_036016639.1  snRNA-activating protein complex subunit 4 isoform X9

    UniProtKB/TrEMBL
    A2AIV6
    Conserved Domains (4) summary
    smart00717
    Location:301 → 344
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    PHA03247
    Location:655 → 1014
    PHA03247; large tegument protein UL36; Provisional
    COG5147
    Location:2 → 284
    REB1; Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning]
    pfam13921
    Location:252 → 312
    Myb_DNA-bind_6; Myb-like DNA-binding domain

  11. XM_030249751.2 → XP_030105611.1  snRNA-activating protein complex subunit 4 isoform X11

    Conserved Domains (4) summary
    smart00717
    Location:98 → 141
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    PHA03247
    Location:452 → 811
    PHA03247; large tegument protein UL36; Provisional
    pfam13921
    Location:49 → 109
    Myb_DNA-bind_6; Myb-like DNA-binding domain
    cl21498
    Location:18 → 57
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

  12. XM_011239069.4 → XP_011237371.1  snRNA-activating protein complex subunit 4 isoform X9

    See identical proteins and their annotated locations for XP_011237371.1

    UniProtKB/TrEMBL
    A2AIV6
    Conserved Domains (4) summary
    smart00717
    Location:301 → 344
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    PHA03247
    Location:655 → 1014
    PHA03247; large tegument protein UL36; Provisional
    COG5147
    Location:2 → 284
    REB1; Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning]
    pfam13921
    Location:252 → 312
    Myb_DNA-bind_6; Myb-like DNA-binding domain

  13. XM_011239070.4 → XP_011237372.1  snRNA-activating protein complex subunit 4 isoform X9

    See identical proteins and their annotated locations for XP_011237372.1

    UniProtKB/TrEMBL
    A2AIV6
    Conserved Domains (4) summary
    smart00717
    Location:301 → 344
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    PHA03247
    Location:655 → 1014
    PHA03247; large tegument protein UL36; Provisional
    COG5147
    Location:2 → 284
    REB1; Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning]
    pfam13921
    Location:252 → 312
    Myb_DNA-bind_6; Myb-like DNA-binding domain

  14. XM_011239067.4 → XP_011237369.1  snRNA-activating protein complex subunit 4 isoform X6

    UniProtKB/TrEMBL
    A2AIV6
    Conserved Domains (4) summary
    smart00717
    Location:363 → 406
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    PHA03247
    Location:717 → 1076
    PHA03247; large tegument protein UL36; Provisional
    COG5147
    Location:102 → 309
    REB1; Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning]
    pfam13921
    Location:314 → 374
    Myb_DNA-bind_6; Myb-like DNA-binding domain

  15. XM_011239068.3 → XP_011237370.1  snRNA-activating protein complex subunit 4 isoform X8

    UniProtKB/TrEMBL
    A2AIV6
    Conserved Domains (4) summary
    smart00717
    Location:314 → 357
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    PHA03247
    Location:668 → 1027
    PHA03247; large tegument protein UL36; Provisional
    COG5147
    Location:53 → 260
    REB1; Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning]
    pfam13921
    Location:265 → 325
    Myb_DNA-bind_6; Myb-like DNA-binding domain

RNA

  1. XR_004939571.1 RNA Sequence

  2. XR_004939572.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BP86.2 GenPept UniProtKB/Swiss-Prot:Q8BP86

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