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Zhx1 zinc fingers and homeoboxes 1 [ Mus musculus (house mouse) ]

Gene ID: 22770, updated on 5-Mar-2024

Summary

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Official Symbol
Zhx1provided by MGI
Official Full Name
zinc fingers and homeoboxes 1provided by MGI
Primary source
MGI:MGI:109271
See related
Ensembl:ENSMUSG00000022361 AllianceGenome:MGI:109271
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable DNA binding activity; DNA-binding transcription factor activity, RNA polymerase II-specific; and protein heterodimerization activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Is active in nucleus. Is expressed in brain; genitourinary system; and thymus. Orthologous to human ZHX1 (zinc fingers and homeoboxes 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 9.2), CNS E18 (RPKM 8.7) and 25 other tissues See more
Orthologs
human all
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Genomic context

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Location:
15 D1; 15 24.25 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (57910399..57939904, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (58047003..58076508, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8589 Neighboring gene predicted gene, 53893 Neighboring gene predicted gene, 22299 Neighboring gene STARR-positive B cell enhancer ABC_E941 Neighboring gene ATPase family, AAA domain containing 2 Neighboring gene small nuclear ribonucleoprotein Sm D2-like Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:57966689-57966916 Neighboring gene STARR-positive B cell enhancer ABC_E3140 Neighboring gene predicted gene, 23475 Neighboring gene N-terminal glutamine amidase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A mechanism of induction of the mouse zinc-fingers and homeoboxes 1 (ZHX1) gene expression by interleukin-2. Shou Z, et al. Biochem Biophys Res Commun, 2004 Feb 13. PMID 14741719
  2. zhx-1: a novel mouse homeodomain protein containing two zinc-fingers and five homeodomains. Barthelemy I, et al. Biochem Biophys Res Commun, 1996 Jul 25. PMID 8713137
  3. Rat zinc-fingers and homeoboxes 1 (ZHX1), a nuclear factor-YA-interacting nuclear protein, forms a homodimer. Hirano S, et al. Gene, 2002 May 15. PMID 12062805
  4. Genomic structure and analysis of transcriptional regulation of the mouse zinc-fingers and homeoboxes 1 (ZHX1) gene. Shou Z, et al. Gene, 2003 Jan 2. PMID 12527199
  5. ZHX proteins regulate podocyte gene expression during the development of nephrotic syndrome. Liu G, et al. J Biol Chem, 2006 Dec 22. PMID 17056598

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ZHX proteins 1, 2 and 3 are major transcriptional mediators of podocyte disease
    Title: ZHX proteins regulate podocyte gene expression during the development of nephrotic syndrome.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA4149, mKIAA4149, 3110006I21Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc fingers and homeoboxes protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042438.2 → NP_001035903.1  zinc fingers and homeoboxes protein 1

    See identical proteins and their annotated locations for NP_001035903.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC113292, AK220508, BC054543, CJ093421, CN533009
    Consensus CDS
    CCDS27488.1
    UniProtKB/Swiss-Prot
    P70121, Q8BQ68, Q8C6T4, Q8CJG3
    UniProtKB/TrEMBL
    Q5DTL2
    Related
    ENSMUSP00000105797.2, ENSMUST00000110168.8
    Conserved Domains (3) summary
    smart00389
    Location:665 → 716
    HOX; Homeodomain
    cd00086
    Location:468 → 523
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam11569
    Location:785 → 821
    Homez; Homeodomain leucine-zipper encoding, Homez

  2. NM_009572.4 → NP_033598.2  zinc fingers and homeoboxes protein 1

    See identical proteins and their annotated locations for NP_033598.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 2. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC113292, AK220508, BC054543, CJ093421
    Consensus CDS
    CCDS27488.1
    UniProtKB/Swiss-Prot
    P70121, Q8BQ68, Q8C6T4, Q8CJG3
    UniProtKB/TrEMBL
    Q5DTL2
    Related
    ENSMUSP00000066201.7, ENSMUST00000070143.13
    Conserved Domains (3) summary
    smart00389
    Location:665 → 716
    HOX; Homeodomain
    cd00086
    Location:468 → 523
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam11569
    Location:785 → 821
    Homez; Homeodomain leucine-zipper encoding, Homez

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    57910399..57939904 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P70121.2 GenPept UniProtKB/Swiss-Prot:P70121

Gene LinkOut

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