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Slc25a25 solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 25 [ Mus musculus (house mouse) ]

Gene ID: 227731, updated on 23-Jun-2021

Summary

Official Symbol
Slc25a25provided by MGI
Official Full Name
solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 25provided by MGI
Primary source
MGI:MGI:1915913
See related
Ensembl:ENSMUSG00000026819
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MCSC; mKIAA1896; 1110030N17Rik
Expression
Ubiquitous expression in liver adult (RPKM 15.8), cerebellum adult (RPKM 9.7) and 28 other tissues See more
Orthologs
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Genomic context

See Slc25a25 in Genome Data Viewer
Location:
2; 2 B
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (32304499..32341482, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (32414487..32451470, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (32270007..32306990, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene prostaglandin E synthase 2 Neighboring gene predicted gene 13413 Neighboring gene nuclear apoptosis inducing factor 1 Neighboring gene family with sequence similarity 102, member A Neighboring gene dolichol-phosphate (beta-D) mannosyltransferase 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC36388

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
calcium-binding mitochondrial carrier protein SCaMC-2
Names
mitochondrial Ca2+-dependent solute carrier
small calcium-binding mitochondrial carrier protein 2
solute carrier family 25 member 25

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164357.1NP_001157829.1  calcium-binding mitochondrial carrier protein SCaMC-2 isoform 2

    See identical proteins and their annotated locations for NP_001157829.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
    Source sequence(s)
    AK132204, BB653459, CO043296
    Consensus CDS
    CCDS50568.1
    UniProtKB/Swiss-Prot
    A2ASZ8
    Related
    ENSMUSP00000108936.3, ENSMUST00000113310.9
    Conserved Domains (3) summary
    cd00051
    Location:115174
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00153
    Location:309401
    Mito_carr; Mitochondrial carrier protein
    pfam13499
    Location:52109
    EF-hand_7; EF-hand domain pair
  2. NM_001164358.1NP_001157830.1  calcium-binding mitochondrial carrier protein SCaMC-2 isoform 3

    See identical proteins and their annotated locations for NP_001157830.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate 5' terminal exon and it thus differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    BC066998, CV784232
    Consensus CDS
    CCDS50567.1
    UniProtKB/Swiss-Prot
    A2ASZ8
    Related
    ENSMUSP00000060581.8, ENSMUST00000052119.14
    Conserved Domains (4) summary
    cd00051
    Location:102173
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00153
    Location:308400
    Mito_carr; Mitochondrial carrier protein
    pfam13499
    Location:103170
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:6397
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
  3. NM_001290558.1NP_001277487.1  calcium-binding mitochondrial carrier protein SCaMC-2 isoform 4

    See identical proteins and their annotated locations for NP_001277487.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate 5' terminal exon and it thus differs in the 5' UTR and 5' coding region, and it lacks an alternate in-frame exon in the central coding region, compared to variant 1. The encoded isoform (4) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK049392, BC066998, BY772900
    Consensus CDS
    CCDS71028.1
    UniProtKB/Swiss-Prot
    A2ASZ8
    Related
    ENSMUSP00000108932.3, ENSMUST00000113307.9
    Conserved Domains (4) summary
    cd00051
    Location:82141
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00153
    Location:276368
    Mito_carr; Mitochondrial carrier protein
    pfam13499
    Location:83138
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:2977
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
  4. NM_001362905.1NP_001349834.1  calcium-binding mitochondrial carrier protein SCaMC-2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL928710
    Consensus CDS
    CCDS89474.1
    Related
    ENSMUSP00000108933.2, ENSMUST00000113308.8
    Conserved Domains (3) summary
    cd15897
    Location:7397
    EFh_PEF; EF-hand motif [structural motif]
    cl25352
    Location:73159
    EFh_PEF; The penta-EF hand (PEF) family
    cl28162
    Location:211465
    Mito_carr; Mitochondrial carrier protein
  5. NM_001362906.1NP_001349835.1  calcium-binding mitochondrial carrier protein SCaMC-2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL928710, BM947090
    Conserved Domains (5) summary
    cd15898
    Location:6796
    EFh_PI-PLC; EF-hand motif [structural motif]
    cd15897
    Location:3662
    EFh_PEF; EF-hand motif [structural motif]
    cl25352
    Location:31110
    EFh_PEF; The penta-EF hand (PEF) family
    cl28162
    Location:188442
    Mito_carr; Mitochondrial carrier protein
    cl28895
    Location:67156
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
  6. NM_001362907.1NP_001349836.1  calcium-binding mitochondrial carrier protein SCaMC-2 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL928710
    Conserved Domains (3) summary
    cd15897
    Location:3662
    EFh_PEF; EF-hand motif [structural motif]
    cl25352
    Location:31124
    EFh_PEF; The penta-EF hand (PEF) family
    cl28162
    Location:176430
    Mito_carr; Mitochondrial carrier protein
  7. NM_146118.3NP_666230.2  calcium-binding mitochondrial carrier protein SCaMC-2 isoform 1

    See identical proteins and their annotated locations for NP_666230.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AL928710
    Consensus CDS
    CCDS15915.1
    UniProtKB/Swiss-Prot
    A2ASZ8
    Related
    ENSMUSP00000028160.9, ENSMUST00000028160.15
    Conserved Domains (3) summary
    cd00051
    Location:53110
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00153
    Location:321413
    Mito_carr; Mitochondrial carrier protein
    pfam13499
    Location:52109
    EF-hand_7; EF-hand domain pair

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    32304499..32341482 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497955.5XP_006498018.1  calcium-binding mitochondrial carrier protein SCaMC-2 isoform X1

    Conserved Domains (5) summary
    PTZ00169
    Location:203457
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    cd15898
    Location:82111
    EFh_PI-PLC; EF-hand motif [structural motif]
    cd15897
    Location:5377
    EFh_PEF; EF-hand motif [structural motif]
    cl28895
    Location:82171
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
    cl25352
    Location:53125
    EFh_PEF; The penta-EF hand (PEF) family
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