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Pip5kl1 phosphatidylinositol-4-phosphate 5-kinase-like 1 [ Mus musculus (house mouse) ]

Gene ID: 227733, updated on 5-Mar-2024

Summary

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Official Symbol
Pip5kl1provided by MGI
Official Full Name
phosphatidylinositol-4-phosphate 5-kinase-like 1provided by MGI
Primary source
MGI:MGI:2448520
See related
Ensembl:ENSMUSG00000046854 AllianceGenome:MGI:2448520
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables 1-phosphatidylinositol-4-phosphate 5-kinase activity. Predicted to be involved in several processes, including negative regulation of cell migration; negative regulation of mitochondrial membrane potential; and negative regulation of protein phosphorylation. Predicted to act upstream of or within phosphorylation. Located in cell projection. Is expressed in integumental system and nervous system. Orthologous to human PIP5KL1 (phosphatidylinositol-4-phosphate 5-kinase like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 5.8), cortex adult (RPKM 2.5) and 6 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 B; 2 22.09 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (32465238..32473799)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (32575226..32583787)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2613 Neighboring gene estrogen-induced osteoclastogenesis regulator 1 Neighboring gene STARR-positive B cell enhancer ABC_E4435 Neighboring gene RIKEN cDNA 9430097D07 gene Neighboring gene dolichyl-phosphate mannosyltransferase subunit 2, regulatory Neighboring gene STARR-positive B cell enhancer ABC_E10095 Neighboring gene ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 Neighboring gene predicted gene, 52551 Neighboring gene predicted gene, 23369 Neighboring gene ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 Neighboring gene STARR-positive B cell enhancer ABC_E10096

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification and characterization of a phosphoinositide phosphate kinase homolog. Chang JD, et al. J Biol Chem, 2004 Mar 19. PMID 14701839
  2. A large multiethnic GWAS meta-analysis of cataract identifies new risk loci and sex-specific effects. Choquet H, et al. Nat Commun, 2021 Jun 14. PMID 34127677, Free PMC Article
  3. Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling. Wilkinson B, et al. Sci Rep, 2017 Jul 13. PMID 28706196, Free PMC Article
  4. Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Miller JA, et al. Development, 2013 Nov. PMID 24154525, Free PMC Article
  5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 1-phosphatidylinositol-4-phosphate 5-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 1-phosphatidylinositol-4-phosphate 5-kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of mitochondrial membrane potential ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphatidylinositol metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylinositol phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell projection IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
phosphatidylinositol 4-phosphate 5-kinase-like protein 1
Names
PI(4)P 5-kinase-like protein 1
PIPKH
phosphatidylinositol phosphate kinase homolog
ptdIns(4)P-5-kinase-like protein 1
NP_001365949.1
NP_001365950.1
NP_937834.1
XP_017172887.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001379020.1 → NP_001365949.1  phosphatidylinositol 4-phosphate 5-kinase-like protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL928710
    Conserved Domains (1) summary
    cd17304
    Location:93 → 435
    PIPKc_PIP5KL1; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in phosphatidylinositol 4-phosphate 5-kinase-like protein 1 (PIP5KL1) and similar proteins

  2. NM_001379021.1 → NP_001365950.1  phosphatidylinositol 4-phosphate 5-kinase-like protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL928710
    Conserved Domains (1) summary
    cd17304
    Location:1 → 338
    PIPKc_PIP5KL1; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in phosphatidylinositol 4-phosphate 5-kinase-like protein 1 (PIP5KL1) and similar proteins

  3. NM_198191.3 → NP_937834.1  phosphatidylinositol 4-phosphate 5-kinase-like protein 1 isoform 2

    See identical proteins and their annotated locations for NP_937834.1

    Status: VALIDATED

    Source sequence(s)
    AL928710, AY376879
    Consensus CDS
    CCDS15920.1
    UniProtKB/Swiss-Prot
    A2ASY7, A2ASY9, Q3TNU0, Q3V0C8, Q52KH3, Q6U7H8, Q8K345
    Related
    ENSMUSP00000051282.8, ENSMUST00000055304.14
    Conserved Domains (1) summary
    pfam01504
    Location:129 → 389
    PIP5K; Phosphatidylinositol-4-phosphate 5-Kinase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    32465238..32473799
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017317398.3 → XP_017172887.1  phosphatidylinositol 4-phosphate 5-kinase-like protein 1 isoform X1

    Conserved Domains (1) summary
    cl28923
    Location:299 → 543
    PIPKc; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6U7H8.1 GenPept UniProtKB/Swiss-Prot:Q6U7H8

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