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MTF2 metal response element binding transcription factor 2 [ Homo sapiens (human) ]

Gene ID: 22823, updated on 11-Apr-2024

Summary

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Official Symbol
MTF2provided by HGNC
Official Full Name
metal response element binding transcription factor 2provided by HGNC
Primary source
HGNC:HGNC:29535
See related
Ensembl:ENSG00000143033 MIM:609882; AllianceGenome:HGNC:29535
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
M96; PCL2; TDRD19A; dJ976O13.2
Summary
Enables methylated histone binding activity and transcription corepressor binding activity. Predicted to be involved in several processes, including regulation of histone H3-K27 methylation; regulation of transcription by RNA polymerase II; and segment specification. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Located in cytoplasm; focal adhesion; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 5.1), lymph node (RPKM 4.5) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
1p22.1
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (93079283..93139076)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (92924870..92984654)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (93544840..93604633)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 210, pseudogene Neighboring gene Sharpr-MPRA regulatory region 7481 Neighboring gene RN7SK pseudogene 123 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1325 Neighboring gene Sharpr-MPRA regulatory region 13810 Neighboring gene Sharpr-MPRA regulatory region 11191 Neighboring gene MPRA-validated peak321 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1081 Neighboring gene transmembrane p24 trafficking protein 5 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1327 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1082 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1328 Neighboring gene ribosomal protein L36a pseudogene 11 Neighboring gene coiled-coil domain containing 18

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Comprehensive Pan-Cancer Analysis of MTF2 Effects on Human Tumors. Tang C, et al. Curr Probl Cancer, 2023 Jun. PMID 37027952
  2. PHF19 mediated regulation of proliferation and invasiveness in prostate cancer cells. Jain P, et al. Elife, 2020 Mar 10. PMID 32155117, Free PMC Article
  3. Targeting the MTF2-MDM2 Axis Sensitizes Refractory Acute Myeloid Leukemia to Chemotherapy. Maganti HB, et al. Cancer Discov, 2018 Nov. PMID 30115703, Free PMC Article
  4. A novel human homologue of Drosophila polycomblike gene is up-regulated in multiple cancers. Wang S, et al. Gene, 2004 Dec 8. PMID 15563832
  5. An aromatic cage is required but not sufficient for binding of Tudor domains of the Polycomblike protein family to H3K36me3. Gatchalian J, et al. Epigenetics, 2015. PMID 25923537, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Tissue-Specific Tumour Suppressor and Oncogenic Activities of the Polycomb-like Protein MTF2.
    Title: Tissue-Specific Tumour Suppressor and Oncogenic Activities of the Polycomb-like Protein MTF2.
  2. Comprehensive Pan-Cancer Analysis of MTF2 Effects on Human Tumors.
    Title: Comprehensive Pan-Cancer Analysis of MTF2 Effects on Human Tumors.
  3. PHF19 mediated regulation of proliferation and invasiveness in prostate cancer cells.
    Title: PHF19 mediated regulation of proliferation and invasiveness in prostate cancer cells.
  4. MTF2 Deficiency is associated with chemoresistance in Acute Myeloid Leukemia.
    Title: Targeting the MTF2-MDM2 Axis Sensitizes Refractory Acute Myeloid Leukemia to Chemotherapy.
  5. the F61L/S86F mutant of MTF2 Tudor-PHD1 was able to bind to H3K36me3 as strong as the PHF1 Tudor bound to this PTM . We concluded that the hydrophobic patch plays an essential role in binding of these Tudors to methylated chromatin
    Title: An aromatic cage is required but not sufficient for binding of Tudor domains of the Polycomblike protein family to H3K36me3.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables methylated histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables methylated histone binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription corepressor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to leukemia inhibitory factor IEA
Inferred from Electronic Annotation
more info
  
involved_in epigenetic regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of gene expression, epigenetic IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in segment specification ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in stem cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in stem cell population maintenance ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of ESC/E(Z) complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
metal-response element-binding transcription factor 2
Names
hPCl2
metal regulatory transcription factor 2
metal-response element DNA-binding protein M96
polycomb-like 2
polycomb-like protein 2
putative DNA binding protein
tudor domain containing 19A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164391.2 → NP_001157863.1  metal-response element-binding transcription factor 2 isoform c

    See identical proteins and their annotated locations for NP_001157863.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate portion of a coding exon compared to variant 1, that causes a frameshift. The resulting isoform (c) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AF072814, AK302776, AL117354, BQ025793, DB173315
    Consensus CDS
    CCDS53341.1
    UniProtKB/TrEMBL
    B4DZG1
    Related
    ENSP00000444962.1, ENST00000545708.5
    Conserved Domains (3) summary
    cd15578
    Location:2 → 54
    PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
    cd15580
    Location:101 → 152
    PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
    pfam14061
    Location:442 → 489
    Mtf2_C; Polycomb-like MTF2 factor 2

  2. NM_001164392.2 → NP_001157864.1  metal-response element-binding transcription factor 2 isoform b

    See identical proteins and their annotated locations for NP_001157864.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AL117354, BC010013, BQ025793, DB173315
    Consensus CDS
    CCDS53340.1
    UniProtKB/TrEMBL
    Q96G26
    Related
    ENSP00000359326.4, ENST00000370303.4
    Conserved Domains (4) summary
    cd15578
    Location:104 → 156
    PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
    cd15580
    Location:203 → 254
    PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
    pfam14061
    Location:487 → 534
    Mtf2_C; Polycomb-like MTF2 factor 2
    cd20450
    Location:45 → 98
    Tudor_MTF2; Tudor domain found in metal-response element-binding transcription factor 2 (MTF2) and similar proteins

  3. NM_001164393.2 → NP_001157865.1  metal-response element-binding transcription factor 2 isoform c

    See identical proteins and their annotated locations for NP_001157865.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two coding exons compared to variant 1, that causes a frameshift. The resulting isoform (c) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AK302900, AL117354, BQ025793
    Consensus CDS
    CCDS53341.1
    UniProtKB/TrEMBL
    B4DZG1
    Related
    ENSP00000443295.1, ENST00000540243.5
    Conserved Domains (3) summary
    cd15578
    Location:2 → 54
    PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
    cd15580
    Location:101 → 152
    PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
    pfam14061
    Location:442 → 489
    Mtf2_C; Polycomb-like MTF2 factor 2

  4. NM_007358.4 → NP_031384.1  metal-response element-binding transcription factor 2 isoform a

    See identical proteins and their annotated locations for NP_031384.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AF086908, AJ010014, AL117354, BC001897, BQ025793, CA417978, DB173315
    Consensus CDS
    CCDS742.1
    UniProtKB/Swiss-Prot
    A6NGQ9, A8K2Q3, B1AKT5, B1AKT6, Q96G26, Q9UES9, Q9UP40, Q9Y483
    Related
    ENSP00000359321.4, ENST00000370298.9
    Conserved Domains (4) summary
    cd15578
    Location:104 → 156
    PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
    cd15580
    Location:203 → 254
    PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
    pfam14061
    Location:544 → 591
    Mtf2_C; Polycomb-like MTF2 factor 2
    cd20450
    Location:45 → 98
    Tudor_MTF2; Tudor domain found in metal-response element-binding transcription factor 2 (MTF2) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    93079283..93139076
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    92924870..92984654
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y483.3 GenPept UniProtKB/Swiss-Prot:Q9Y483

Gene LinkOut

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