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Smox spermine oxidase [ Mus musculus (house mouse) ]

Gene ID: 228608, updated on 2-Oct-2021

Summary

Official Symbol
Smoxprovided by MGI
Official Full Name
spermine oxidaseprovided by MGI
Primary source
MGI:MGI:2445356
See related
Ensembl:ENSMUSG00000027333
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PAO; SMO; PAOh1; B130066H01Rik
Expression
Ubiquitous expression in liver E14.5 (RPKM 27.2), liver E14 (RPKM 26.0) and 27 other tissues See more
Orthologs
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Genomic context

See Smox in Genome Data Viewer
Location:
2; 2 F1
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (131333624..131367103)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (131491858..131525183)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (131317598..131350919)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene aldo-keto reductase family 1 member A1-like Neighboring gene predicted gene 14304 Neighboring gene predicted gene, 30679 Neighboring gene predicted gene, 30732 Neighboring gene predicted gene, 39938 Neighboring gene adrenergic receptor, alpha 1d

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables N1-acetylspermine:oxygen oxidoreductase (N1-acetylspermidine-forming) activity IEA
Inferred from Electronic Annotation
more info
 
enables norspermine:oxygen oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables polyamine oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables polyamine oxidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables polyamine oxidase activity ISO
Inferred from Sequence Orthology
more info
 
enables spermine:oxygen oxidoreductase (spermidine-forming) activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in polyamine catabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within spermine catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in spermine catabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
spermine oxidase
Names
PAO-1
polyamine oxidase 1
NP_001171304.1
NP_001171305.1
NP_001171306.1
NP_001171307.1
NP_001171308.1
NP_001171309.1
NP_001171310.1
NP_001171311.1
NP_663508.1
XP_006499350.1
XP_006499351.1
XP_006499352.1
XP_006499353.1
XP_006499354.1
XP_006499355.1
XP_006499356.1
XP_011237777.1
XP_017173258.1
XP_030106328.1
XP_030106330.1
XP_030106332.1
XP_030106336.1
XP_030106341.1
XP_030106346.1
XP_030106347.1
XP_030106354.1
XP_030106358.1
XP_030106360.1
XP_030106369.1
XP_030106371.1
XP_030106373.1
XP_036017254.1
XP_036017255.1
XP_036017256.1
XP_036017258.1
XP_036017259.1
XP_036017261.1
XP_036017262.1
XP_036017263.1
XP_036017264.1
XP_036017276.1
XP_036017285.1
XP_036017288.1
XP_036017293.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177833.1NP_001171304.1  spermine oxidase isoform a

    See identical proteins and their annotated locations for NP_001171304.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is the longest transcript and it encodes the longest protein (isoform a). This variant has also been called 'splice variant mu'.
    Source sequence(s)
    AI466340, AK143129, BQ174872, BQ895563
    Consensus CDS
    CCDS50719.1
    UniProtKB/Swiss-Prot
    Q99K82
    UniProtKB/TrEMBL
    Q3UPW5
    Related
    ENSMUSP00000105815.3, ENSMUST00000110186.9
    Conserved Domains (1) summary
    PLN02568
    Location:50578
    PLN02568; polyamine oxidase
  2. NM_001177834.1NP_001171305.1  spermine oxidase isoform c

    See identical proteins and their annotated locations for NP_001171305.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses a different splice site and lacks an alternate exon, which shifts the reading frame, compared to variant 1. The resulting protein (isoform c) is shorter and has a distinct C-terminus when it is compared to isoform a. This variant has also been called 'splice variant beta'.
    Source sequence(s)
    AK143129, BQ174872, BQ895563
    Consensus CDS
    CCDS50720.1
    UniProtKB/Swiss-Prot
    Q99K82
    UniProtKB/TrEMBL
    Q3UPW5
    Related
    ENSMUSP00000105817.2, ENSMUST00000110188.8
    Conserved Domains (2) summary
    PLN02568
    Location:50457
    PLN02568; polyamine oxidase
    pfam13450
    Location:4588
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
  3. NM_001177835.1NP_001171306.1  spermine oxidase isoform d

    See identical proteins and their annotated locations for NP_001171306.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two alternate exons which shifts the reading frame, compared to variant 1. The resulting protein (isoform d) is shorter and has a distinct C-terminus when it is compared to isoform a. This transcript has also been called 'splice variant gamma'.
    Source sequence(s)
    AK143129, BQ174872, BQ895563
    Consensus CDS
    CCDS50721.1
    UniProtKB/Swiss-Prot
    Q99K82
    UniProtKB/TrEMBL
    Q3UPW5
    Related
    ENSMUSP00000105818.3, ENSMUST00000110189.9
    Conserved Domains (1) summary
    PLN02568
    Location:50445
    PLN02568; polyamine oxidase
  4. NM_001177836.1NP_001171307.1  spermine oxidase isoform e

    See identical proteins and their annotated locations for NP_001171307.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses a different splice site and lacks an alternate, in-frame exon, compared to variant 1. The resulting protein (isoform e) is shorter when it is compared to isoform a. This transcript and protein have also been called 'polyamine oxidase-m'.
    Source sequence(s)
    AK143129, BQ174872, BQ895563
    Consensus CDS
    CCDS50718.1
    UniProtKB/Swiss-Prot
    Q99K82
    UniProtKB/TrEMBL
    Q3UPW5
    Related
    ENSMUSP00000105809.2, ENSMUST00000110180.2
    Conserved Domains (1) summary
    PLN02568
    Location:50412
    PLN02568; polyamine oxidase
  5. NM_001177837.1NP_001171308.1  spermine oxidase isoform f

    See identical proteins and their annotated locations for NP_001171308.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) uses a different splice site and lacks an alternate, in-frame exon, compared to variant 1. The resulting protein (isoform f) is shorter when it is compared to isoform a.
    Source sequence(s)
    AK143129, AK166350, BQ174872, BQ895563
    Consensus CDS
    CCDS50722.1
    UniProtKB/TrEMBL
    Q3TLR8, Q3UPW5
    Related
    ENSMUSP00000105810.2, ENSMUST00000110181.8
    Conserved Domains (2) summary
    pfam01593
    Location:45374
    Amino_oxidase; Flavin containing amine oxidoreductase
    pfam13450
    Location:4588
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
  6. NM_001177838.1NP_001171309.1  spermine oxidase isoform g

    See identical proteins and their annotated locations for NP_001171309.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) lacks three alternate exons but maintains the reading frame, compared to variant 1. The resulting protein (isoform g) is shorter when it is compared to isoform a. This transcript has also been called 'splice variant phi'.
    Source sequence(s)
    AK143129, BQ174872, BQ895563
    Consensus CDS
    CCDS50724.1
    UniProtKB/Swiss-Prot
    Q99K82
    UniProtKB/TrEMBL
    Q3UPW5
    Related
    ENSMUSP00000105812.3, ENSMUST00000110183.9
    Conserved Domains (1) summary
    pfam13450
    Location:4588
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
  7. NM_001177839.1NP_001171310.1  spermine oxidase isoform h

    See identical proteins and their annotated locations for NP_001171310.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) lacks two alternate exons, which changes the reading frame and results in a premature stop codon, compared to variant 1. The resulting protein (isoform h) has a shorter and distinct C-terminus when it is compared to isoform a. This transcript has also been called 'splice variant epsilon' and 'polyamine oxidase-s'.
    Source sequence(s)
    AK143129, BQ174872, BQ895563
    Consensus CDS
    CCDS50723.1
    UniProtKB/Swiss-Prot
    Q99K82
    UniProtKB/TrEMBL
    A2ANQ4, Q3UPW5
    Related
    ENSMUSP00000105808.3, ENSMUST00000110179.9
    Conserved Domains (1) summary
    pfam01593
    Location:45193
    Amino_oxidase; Flavin containing amine oxidoreductase
  8. NM_001177840.1NP_001171311.1  spermine oxidase isoform i

    See identical proteins and their annotated locations for NP_001171311.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) lacks four alternate exons but maintains the reading frame, compared to variant 1. The resulting protein (isoform i) is shorter when it is compared to isoform a. This transcript has also been called 'splice variant delta'.
    Source sequence(s)
    AK143129, BQ174872, BQ895563
    Consensus CDS
    CCDS50725.1
    UniProtKB/Swiss-Prot
    Q99K82
    UniProtKB/TrEMBL
    Q3UPW5
    Related
    ENSMUSP00000105811.3, ENSMUST00000110182.9
    Conserved Domains (1) summary
    pfam13450
    Location:4588
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
  9. NM_145533.2NP_663508.1  spermine oxidase isoform b

    See identical proteins and their annotated locations for NP_663508.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate, in-frame, exon, compared to variant 1. The resulting protein (isoform b) is shorter when it is compared to isoform a. This transcript and protein have also been called 'polyamine oxidase-l'.
    Source sequence(s)
    AK143129, BQ174872, BQ895563
    Consensus CDS
    CCDS16763.1
    UniProtKB/Swiss-Prot
    Q99K82
    UniProtKB/TrEMBL
    Q3UPW5
    Related
    ENSMUSP00000028806.6, ENSMUST00000028806.12
    Conserved Domains (1) summary
    PLN02568
    Location:50548
    PLN02568; polyamine oxidase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    131333624..131367103
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161366.1XP_036017259.1  spermine oxidase isoform X2

    Conserved Domains (1) summary
    PLN02568
    Location:50577
    PLN02568; polyamine oxidase
  2. XM_036161365.1XP_036017258.1  spermine oxidase isoform X1

    Conserved Domains (1) summary
    PLN02568
    Location:50578
    PLN02568; polyamine oxidase
  3. XM_036161371.1XP_036017264.1  spermine oxidase isoform X3

    Conserved Domains (1) summary
    PLN02568
    Location:50548
    PLN02568; polyamine oxidase
  4. XM_006499290.3XP_006499353.1  spermine oxidase isoform X5

    Conserved Domains (1) summary
    PLN02568
    Location:50513
    PLN02568; polyamine oxidase
  5. XM_006499293.4XP_006499356.1  spermine oxidase isoform X12

    Conserved Domains (1) summary
    PLN02568
    Location:50403
    PLN02568; polyamine oxidase
  6. XM_017317769.2XP_017173258.1  spermine oxidase isoform X14

    Conserved Domains (1) summary
    PLN02568
    Location:50373
    PLN02568; polyamine oxidase
  7. XM_030250476.2XP_030106336.1  spermine oxidase isoform X4

    Conserved Domains (1) summary
    PLN02568
    Location:50547
    PLN02568; polyamine oxidase
  8. XM_006499291.2XP_006499354.1  spermine oxidase isoform X8

    Conserved Domains (1) summary
    PLN02568
    Location:50442
    PLN02568; polyamine oxidase
  9. XM_036161395.1XP_036017288.1  spermine oxidase isoform X15

    Conserved Domains (1) summary
    PLN02568
    Location:50266
    PLN02568; polyamine oxidase
  10. XM_006499289.5XP_006499352.1  spermine oxidase isoform X2

    Conserved Domains (1) summary
    PLN02568
    Location:50577
    PLN02568; polyamine oxidase
  11. XM_006499287.4XP_006499350.1  spermine oxidase isoform X1

    See identical proteins and their annotated locations for XP_006499350.1

    UniProtKB/Swiss-Prot
    Q99K82
    Conserved Domains (1) summary
    PLN02568
    Location:50578
    PLN02568; polyamine oxidase
  12. XM_030250468.1XP_030106328.1  spermine oxidase isoform X3

    Conserved Domains (1) summary
    PLN02568
    Location:50548
    PLN02568; polyamine oxidase
  13. XM_030250500.1XP_030106360.1  spermine oxidase isoform X11

    Conserved Domains (1) summary
    PLN02568
    Location:50411
    PLN02568; polyamine oxidase
  14. XM_011239475.3XP_011237777.1  spermine oxidase isoform X16

    Conserved Domains (2) summary
    PLN02568
    Location:226271
    PLN02568; polyamine oxidase
    pfam01593
    Location:45115
    Amino_oxidase; Flavin containing amine oxidoreductase
  15. XM_030250509.1XP_030106369.1  spermine oxidase isoform X13

    Conserved Domains (1) summary
    PLN02568
    Location:43400
    PLN02568; polyamine oxidase
  16. XM_030250487.2XP_030106347.1  spermine oxidase isoform X7

    Conserved Domains (1) summary
    PLN02568
    Location:50444
    PLN02568; polyamine oxidase
  17. XM_006499292.4XP_006499355.1  spermine oxidase isoform X9

    Conserved Domains (1) summary
    PLN02568
    Location:43430
    PLN02568; polyamine oxidase
  18. XM_036161370.1XP_036017263.1  spermine oxidase isoform X3

    Conserved Domains (1) summary
    PLN02568
    Location:50548
    PLN02568; polyamine oxidase
  19. XM_036161383.1XP_036017276.1  spermine oxidase isoform X10

    Conserved Domains (1) summary
    PLN02568
    Location:50412
    PLN02568; polyamine oxidase
  20. XM_036161363.1XP_036017256.1  spermine oxidase isoform X1

    Conserved Domains (1) summary
    PLN02568
    Location:50578
    PLN02568; polyamine oxidase
  21. XM_036161400.1XP_036017293.1  spermine oxidase isoform X17

    Conserved Domains (1) summary
    pfam01593
    Location:45193
    Amino_oxidase; Flavin containing amine oxidoreductase
  22. XM_036161361.1XP_036017254.1  spermine oxidase isoform X1

    Conserved Domains (1) summary
    PLN02568
    Location:50578
    PLN02568; polyamine oxidase
  23. XM_030250513.2XP_030106373.1  spermine oxidase isoform X17

    Conserved Domains (1) summary
    pfam01593
    Location:45193
    Amino_oxidase; Flavin containing amine oxidoreductase
  24. XM_030250472.2XP_030106332.1  spermine oxidase isoform X3

    Conserved Domains (1) summary
    PLN02568
    Location:50548
    PLN02568; polyamine oxidase
  25. XM_036161368.1XP_036017261.1  spermine oxidase isoform X3

    Conserved Domains (1) summary
    PLN02568
    Location:50548
    PLN02568; polyamine oxidase
  26. XM_030250470.1XP_030106330.1  spermine oxidase isoform X3

    Conserved Domains (1) summary
    PLN02568
    Location:50548
    PLN02568; polyamine oxidase
  27. XM_006499288.3XP_006499351.1  spermine oxidase isoform X1

    See identical proteins and their annotated locations for XP_006499351.1

    UniProtKB/Swiss-Prot
    Q99K82
    Conserved Domains (1) summary
    PLN02568
    Location:50578
    PLN02568; polyamine oxidase
  28. XM_030250486.1XP_030106346.1  spermine oxidase isoform X6

    Conserved Domains (1) summary
    PLN02568
    Location:50445
    PLN02568; polyamine oxidase
  29. XM_030250494.1XP_030106354.1  spermine oxidase isoform X8

    Conserved Domains (1) summary
    PLN02568
    Location:50442
    PLN02568; polyamine oxidase
  30. XM_030250498.1XP_030106358.1  spermine oxidase isoform X10

    Conserved Domains (1) summary
    PLN02568
    Location:50412
    PLN02568; polyamine oxidase
  31. XM_036161392.1XP_036017285.1  spermine oxidase isoform X12

    Conserved Domains (1) summary
    PLN02568
    Location:50403
    PLN02568; polyamine oxidase
  32. XM_030250511.2XP_030106371.1  spermine oxidase isoform X17

    Conserved Domains (1) summary
    pfam01593
    Location:45193
    Amino_oxidase; Flavin containing amine oxidoreductase
  33. XM_030250481.1XP_030106341.1  spermine oxidase isoform X4

    Conserved Domains (1) summary
    PLN02568
    Location:50547
    PLN02568; polyamine oxidase
  34. XM_036161362.1XP_036017255.1  spermine oxidase isoform X1

    Conserved Domains (1) summary
    PLN02568
    Location:50578
    PLN02568; polyamine oxidase
  35. XM_036161369.1XP_036017262.1  spermine oxidase isoform X3

    Conserved Domains (1) summary
    PLN02568
    Location:50548
    PLN02568; polyamine oxidase

RNA

  1. XR_374452.3 RNA Sequence

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