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Npepl1 aminopeptidase-like 1 [ Mus musculus (house mouse) ]

Gene ID: 228961, updated on 11-Apr-2024

Summary

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Official Symbol
Npepl1provided by MGI
Official Full Name
aminopeptidase-like 1provided by MGI
Primary source
MGI:MGI:2448523
See related
Ensembl:ENSMUSG00000039263 AllianceGenome:MGI:2448523
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1974
Summary
Predicted to enable peptidase activity. Predicted to be involved in protein metabolic process. Predicted to be active in cytoplasm. Orthologous to human NPEPL1 (aminopeptidase like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 80.4), adrenal adult (RPKM 69.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Npepl1 in Genome Data Viewer
Location:
2 H4; 2 97.87 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (173951904..173964495)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (174110338..174122702)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene vesicle-associated membrane protein 7, pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E7892 Neighboring gene syntaxin 16 Neighboring gene predicted gene 10714 Neighboring gene STARR-seq mESC enhancer starr_06632 Neighboring gene microRNA 296

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
  2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  3. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables aminopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables manganese ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metalloaminopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in protein metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
probable aminopeptidase NPEPL1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001378793.1 → NP_001365722.1  probable aminopeptidase NPEPL1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL669896
    UniProtKB/TrEMBL
    Q3TCV9, Q3U199, Q3UD03
    Conserved Domains (1) summary
    cd00433
    Location:35 → 492
    Peptidase_M17; Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and ...

  2. NM_213733.2 → NP_998898.1  probable aminopeptidase NPEPL1 isoform 2

    See identical proteins and their annotated locations for NP_998898.1

    Status: VALIDATED

    Source sequence(s)
    AK150313, BU148687, BX517579
    Consensus CDS
    CCDS17148.1
    UniProtKB/Swiss-Prot
    A2ACM6, Q66JY0, Q6NSR8
    UniProtKB/TrEMBL
    Q3TCV9, Q3U199, Q3UD03
    Related
    ENSMUSP00000042808.10, ENSMUST00000044415.16
    Conserved Domains (1) summary
    cd00433
    Location:35 → 487
    Peptidase_M17; Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    173951904..173964495
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_374463.2 RNA Sequence

  2. XR_374462.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6NSR8.1 GenPept UniProtKB/Swiss-Prot:Q6NSR8

Gene LinkOut

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