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Ciart circadian associated repressor of transcription [ Mus musculus (house mouse) ]

Gene ID: 229599, updated on 21-Apr-2024

Summary

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Official Symbol
Ciartprovided by MGI
Official Full Name
circadian associated repressor of transcriptionprovided by MGI
Primary source
MGI:MGI:2684975
See related
Ensembl:ENSMUSG00000038550 AllianceGenome:MGI:2684975
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm129; Chrono
Summary
Enables E-box binding activity. Involved in circadian regulation of gene expression; locomotor rhythm; and negative regulation of transcription, DNA-templated. Located in nucleus. Orthologous to human CIART (circadian associated repressor of transcription). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bladder adult (RPKM 9.0), cortex adult (RPKM 8.4) and 20 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3 F2.1; 3 41.42 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (95785812..95790012, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (95878500..95882257, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene pre-mRNA processing factor 3 Neighboring gene STARR-positive B cell enhancer ABC_E10199 Neighboring gene RIKEN cDNA C920021L13 gene Neighboring gene mitochondrial ribosomal protein S21 Neighboring gene STARR-positive B cell enhancer ABC_E9562 Neighboring gene cDNA sequence BC028528 Neighboring gene STARR-positive B cell enhancer ABC_E2673 Neighboring gene aph1 homolog A, gamma secretase subunit Neighboring gene carbonic anhydrase 14 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:95732686-95732932 Neighboring gene predicted gene, 46815

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CHRONO and DEC1/DEC2 compensate for lack of CRY1/CRY2 in expression of coherent circadian rhythm but not in generation of circadian oscillation in the neonatal mouse SCN. Ono D, et al. Sci Rep, 2021 Sep 28. PMID 34584158, Free PMC Article
  2. Machine learning helps identify CHRONO as a circadian clock component. Anafi RC, et al. PLoS Biol, 2014 Apr. PMID 24737000, Free PMC Article
  3. Gene model 129 (Gm129) encodes a novel transcriptional repressor that modulates circadian gene expression. Annayev Y, et al. J Biol Chem, 2014 Feb 21. PMID 24385426, Free PMC Article
  4. A catalogue of genes in mouse embryonal carcinoma F9 cells identified with expressed sequence tags. Nishiguchi S, et al. J Biochem, 1996 Apr. PMID 8743579
  5. A novel protein, CHRONO, functions as a core component of the mammalian circadian clock. Goriki A, et al. PLoS Biol, 2014 Apr. PMID 24736997, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CHRONO and DEC1/DEC2 compensate for lack of CRY1/CRY2 in expression of coherent circadian rhythm but not in generation of circadian oscillation in the neonatal mouse SCN.
    Title: CHRONO and DEC1/DEC2 compensate for lack of CRY1/CRY2 in expression of coherent circadian rhythm but not in generation of circadian oscillation in the neonatal mouse SCN.
  2. CHRONO interferes with the ability of BMAL1 to recruit CBP, a bona fide histone acetylase and key transcriptional coactivator of the circadian clock.
    Title: Machine learning helps identify CHRONO as a circadian clock component.
  3. Chrono binds to the regulatory region of clock genes and its occupancy oscillates in a circadian manner.
    Title: A novel protein, CHRONO, functions as a core component of the mammalian circadian clock.
  4. The GM129 protein contributes to the transcriptional feedback loop by modulating CLOCK.BMAL1 activity as a transcriptional repressor.
    Title: Gene model 129 (Gm129) encodes a novel transcriptional repressor that modulates circadian gene expression.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2) 
  • Endonuclease-mediated (5) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables E-box binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription cis-regulatory region binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in circadian regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in circadian regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in locomotor rhythm IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within rhythmic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
circadian-associated transcriptional repressor
Names
chIP-derived repressor of network oscillator
computationally highlighted repressor of the network oscillator

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033302.3 → NP_001028474.1  circadian-associated transcriptional repressor isoform 1

    See identical proteins and their annotated locations for NP_001028474.1

    Status: VALIDATED

    Source sequence(s)
    AC092855
    Consensus CDS
    CCDS50997.1
    UniProtKB/Swiss-Prot
    Q3TQ03, Q3U1B8
    UniProtKB/TrEMBL
    A2RTE4
    Related
    ENSMUSP00000049308.4, ENSMUST00000036418.10
    Conserved Domains (1) summary
    pfam15673
    Location:85 → 360
    Ciart; Circadian-associated transcriptional repressor

  2. NM_001411319.1 → NP_001398248.1  circadian-associated transcriptional repressor isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC092855
    UniProtKB/Swiss-Prot
    Q3TQ03, Q3U1B8
    UniProtKB/TrEMBL
    A2RTE4

  3. NM_001411320.1 → NP_001398249.1  circadian-associated transcriptional repressor isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC092855
    UniProtKB/Swiss-Prot
    Q3TQ03, Q3U1B8
    UniProtKB/TrEMBL
    A2RTE4

  4. NM_001411321.1 → NP_001398250.1  circadian-associated transcriptional repressor isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC092855
    UniProtKB/Swiss-Prot
    Q3TQ03, Q3U1B8
    UniProtKB/TrEMBL
    A2RTE4

  5. NM_001411322.1 → NP_001398251.1  circadian-associated transcriptional repressor isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC092855
    UniProtKB/Swiss-Prot
    Q3TQ03, Q3U1B8
    UniProtKB/TrEMBL
    A2RTE4

  6. NM_001411323.1 → NP_001398252.1  circadian-associated transcriptional repressor isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC092855
    UniProtKB/Swiss-Prot
    Q3TQ03, Q3U1B8
    UniProtKB/TrEMBL
    A2RTE4
    Related
    ENSMUSP00000124943.2, ENSMUST00000159739.8

  7. NM_001411324.1 → NP_001398253.1  circadian-associated transcriptional repressor isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC092855

  8. NM_001411325.1 → NP_001398254.1  circadian-associated transcriptional repressor isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC092855

  9. NM_001411326.1 → NP_001398255.1  circadian-associated transcriptional repressor isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC092855

  10. NM_001411327.1 → NP_001398256.1  circadian-associated transcriptional repressor isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC092855

  11. NM_001411328.1 → NP_001398257.1  circadian-associated transcriptional repressor isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC092855

  12. NM_001411329.1 → NP_001398258.1  circadian-associated transcriptional repressor isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC092855

  13. NM_001411330.1 → NP_001398259.1  circadian-associated transcriptional repressor isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC092855

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    95785812..95790012 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3TQ03.1 GenPept UniProtKB/Swiss-Prot:Q3TQ03

Gene LinkOut

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