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Amigo1 adhesion molecule with Ig like domain 1 [ Mus musculus (house mouse) ]

Gene ID: 229715, updated on 23-Jun-2021

Summary

Official Symbol
Amigo1provided by MGI
Official Full Name
adhesion molecule with Ig like domain 1provided by MGI
Primary source
MGI:MGI:2653612
See related
Ensembl:ENSMUSG00000050947
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ali2; Amigo
Expression
Ubiquitous expression in frontal lobe adult (RPKM 13.9), cerebellum adult (RPKM 10.9) and 24 other tissues See more
Orthologs
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Genomic context

See Amigo1 in Genome Data Viewer
Location:
3; 3 F2.3
Exon count:
2
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (108093605..108099602)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (108186289..108192286)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (107989253..107994695)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 61 Neighboring gene predicted gene, 40122 Neighboring gene cytochrome b-561 domain containing 1 Neighboring gene ataxin 7-like 2 Neighboring gene synaptophysin-like 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC25558, RP23-89M15.6

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables potassium channel regulator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in axonal fasciculation ISO
Inferred from Sequence Orthology
more info
 
involved_in axonal fasciculation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
acts_upstream_of_or_within axonogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in axonogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in brain development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within cell adhesion ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to L-glutamate ISO
Inferred from Sequence Orthology
more info
 
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ISO
Inferred from Sequence Orthology
more info
 
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in homophilic cell adhesion via plasma membrane adhesion molecules ISO
Inferred from Sequence Orthology
more info
 
involved_in homophilic cell adhesion via plasma membrane adhesion molecules ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in myelination ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron projection fasciculation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of axonogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of axonogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of potassium ion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of synapse assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of voltage-gated potassium channel activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in integral component of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in pericellular basket ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
part_of voltage-gated potassium channel complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
amphoterin-induced protein 1
Names
AMIGO-1
alivin 2
amphoterin induced gene and ORF (Amigo)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004293.2NP_001004293.1  amphoterin-induced protein 1 isoform a precursor

    See identical proteins and their annotated locations for NP_001004293.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein (isoform a).
    Source sequence(s)
    AK035960, AK173118, AL671854, BB645598
    Consensus CDS
    CCDS17753.1
    UniProtKB/Swiss-Prot
    Q80ZD8
    Related
    ENSMUSP00000102267.2, ENSMUST00000106656.2
    Conserved Domains (5) summary
    smart00410
    Location:279357
    IG_like; Immunoglobulin like
    cd00116
    Location:64198
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:4464
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:110170
    LRR_8; Leucine rich repeat
    cl11960
    Location:283342
    Ig; Immunoglobulin domain
  2. NM_001287093.1NP_001274022.1  amphoterin-induced protein 1 isoform b precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and has a different 3' structure resulting in a frameshift compared to variant 1. The encoded protein (isoform b) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AL671854
    Consensus CDS
    CCDS71305.1
    UniProtKB/Swiss-Prot
    Q80ZD8
    Related
    ENSMUSP00000102270.3, ENSMUST00000106659.3
    Conserved Domains (2) summary
    PRK15370
    Location:30213
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    sd00033
    Location:4464
    LRR_RI; leucine-rich repeat [structural motif]
  3. NM_146137.3NP_666249.2  amphoterin-induced protein 1 isoform a precursor

    See identical proteins and their annotated locations for NP_666249.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK173118, AL671854, BB645598
    Consensus CDS
    CCDS17753.1
    UniProtKB/Swiss-Prot
    Q80ZD8
    Related
    ENSMUSP00000061244.7, ENSMUST00000050909.7
    Conserved Domains (5) summary
    smart00410
    Location:279357
    IG_like; Immunoglobulin like
    cd00116
    Location:64198
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:4464
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:110170
    LRR_8; Leucine rich repeat
    cl11960
    Location:283342
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    108093605..108099602
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163076.1XP_036018969.1  amphoterin-induced protein 1 isoform X1

    Conserved Domains (2) summary
    PRK15370
    Location:30213
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    sd00033
    Location:4464
    LRR_RI; leucine-rich repeat [structural motif]
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