Clca3b chloride channel accessory 3B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Clca3bprovided by MGI
Official Full Name: chloride channel accessory 3Bprovided by MGI
Primary source: MGI:MGI:2181989
See related: Ensembl:ENSMUSG00000037033 AllianceGenome:MGI:2181989
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Clca4
Summary: Predicted to enable intracellular calcium activated chloride channel activity. Predicted to be integral component of plasma membrane. Is expressed in several structures, including brain; genitourinary system; gut; olfactory epithelium; and thymus. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in large intestine adult (RPKM 77.2), colon adult (RPKM 37.3) and 2 other tissues See more
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Genomic context

Location:: 3 H2; 3 69.14 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (144528384..144555063, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (144822623..144849302, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The 125-kDa mCLCA4 gene product is cleaved to 90- and 40-kDa fragments, and the NH(2)- and COOH-terminal fragments are secreted, where they are found in cell media and associated with the plasma membrane.
Title: mCLCA4 ER processing and secretion requires luminal sorting motifs.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)

General gene information

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Markers

Clca4 (e-PCR), detects polymorphism
- UniSTS:547970

Clca4 (e-PCR), detects polymorphism
- UniSTS:547971

Clca4 (e-PCR), detects polymorphism
- UniSTS:547972

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables intracellularly calcium-gated chloride channel activity	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: chloride channel accessory 3B

Names: calcium-activated chloride channel CLCA4; chloride channel calcium activated 3B; chloride channel calcium activated 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_139148.2 → NP_631887.2 chloride channel accessory 3B precursor

Status: PROVISIONAL

Source sequence(s)

AC137128, AY008277

Consensus CDS

CCDS51086.1

UniProtKB/TrEMBL

E9PUL3, Q91ZF5

Related

ENSMUSP00000124581.2, ENSMUST00000159989.2

Conserved Domains (6) summary

TIGR00868
Location:1 → 869

hCaCC; calcium-activated chloride channel protein 1

pfam01391
Location:966 → 1022

Collagen; Collagen triple helix repeat (20 copies)

cd00198
Location:307 → 464

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

pfam04880
Location:859 → 989

NUDE_C; NUDE protein, C-terminal conserved region

pfam06346
Location:875 → 1021

Drf_FH1; Formin Homology Region 1

cl19929
Location:532 → 572

A2M_N; MG2 domain