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Aldob aldolase B, fructose-bisphosphate [ Mus musculus (house mouse) ]

Gene ID: 230163, updated on 23-Jun-2021

Summary

Official Symbol
Aldobprovided by MGI
Official Full Name
aldolase B, fructose-bisphosphateprovided by MGI
Primary source
MGI:MGI:87995
See related
Ensembl:ENSMUSG00000028307
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Al; Ald; Aldo2; Aldo-2; BC016435
Summary
This gene encodes a subunit of the homotetrameric enzyme aldolase B, an isozyme of the class I fructose 1,6-bisphosphate aldolase enzyme. This enzyme catalyzes the conversion of fructose 1,6-bisphosphate to dihydroxyacetone phosphate and glyceraldehyde 3-phosphate. Homozygous knockout mice for this gene exhibit liver damage and death following fructose ingestion. A pseudogene of this gene has been identified in the genome. [provided by RefSeq, Aug 2015]
Expression
Biased expression in kidney adult (RPKM 1344.8), liver adult (RPKM 757.5) and 5 other tissues See more
Orthologs
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Genomic context

See Aldob in Genome Data Viewer
Location:
4 B1; 4 26.57 cM
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (49535993..49549546, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (49535993..49549546, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (49548867..49562355, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L50 Neighboring gene zinc finger protein 189 Neighboring gene post-GPI attachment to proteins GalNAc transferase 4 Neighboring gene predicted gene, 33106 Neighboring gene predicted gene, 33159

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC36398

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATPase binding ISO
Inferred from Sequence Orthology
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables cytoskeletal protein binding ISO
Inferred from Sequence Orthology
more info
 
enables fructose binding ISO
Inferred from Sequence Orthology
more info
 
enables fructose-1-phosphate aldolase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables fructose-1-phosphate aldolase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables fructose-1-phosphate aldolase activity ISO
Inferred from Sequence Orthology
more info
 
enables fructose-bisphosphate aldolase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables fructose-bisphosphate aldolase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables fructose-bisphosphate aldolase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables fructose-bisphosphate aldolase activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylcholine binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in lysosome ISO
Inferred from Sequence Orthology
more info
 
located_in microtubule organizing center ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in rough endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in smooth endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
fructose-bisphosphate aldolase B
Names
liver-type aldolase
NP_659152.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_144903.3NP_659152.1  fructose-bisphosphate aldolase B

    See identical proteins and their annotated locations for NP_659152.1

    Status: REVIEWED

    Source sequence(s)
    AK167566, AK168997, AL772310
    Consensus CDS
    CCDS18176.1
    UniProtKB/Swiss-Prot
    Q91Y97
    UniProtKB/TrEMBL
    Q3TJ66, Q3UER1
    Related
    ENSMUSP00000029987.10, ENSMUST00000029987.10
    Conserved Domains (1) summary
    pfam00274
    Location:15364
    Glycolytic; Fructose-bisphosphate aldolase class-I

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    49535993..49549546 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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