Abitram actin binding transcription modulator [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Abitramprovided by MGI
Official Full Name: actin binding transcription modulatorprovided by MGI
Primary source: MGI:MGI:2677850
See related: Ensembl:ENSMUSG00000038827 AllianceGenome:MGI:2677850
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fam206a; simiate
Summary: Enables actin filament binding activity and actin monomer binding activity. Involved in dendrite morphogenesis; regulation of actin filament polymerization; and regulation of filopodium assembly. Located in several cellular components, including filopodium tip; lamellipodium; and nuclear speck. Is expressed in cartilage; endocrine gland; genitourinary system; nervous system; and trachea. Orthologous to human ABITRAM (actin binding transcription modulator). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in testis adult (RPKM 5.0), limb E14.5 (RPKM 3.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 B3; 4 31.66 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (56802329..56809605)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (56802329..56809605)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Simiate and the focal adhesion kinase FAK1 cooperate in the regulation of dendritogenesis.
Title: Simiate and the focal adhesion kinase FAK1 cooperate in the regulation of dendritogenesis.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IDA Inferred from Direct Assay more info	PubMed
enables actin monomer binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin monomer binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in dendrite morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of actin filament polymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of actin filament polymerization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of filopodium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of filopodium assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
is_active_in filopodium tip	IBA Inferred from Biological aspect of Ancestor more info
located_in filopodium tip	IDA Inferred from Direct Assay more info	PubMed
located_in growth cone	IDA Inferred from Direct Assay more info	PubMed
is_active_in lamellipodium	IBA Inferred from Biological aspect of Ancestor more info
located_in lamellipodium	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear speck	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: protein Abitram

Names: family with sequence similarity 206, member A; protein FAM206A; protein Simiate

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081420.1 → NP_001074889.1 protein Abitram

See identical proteins and their annotated locations for NP_001074889.1

Status: PROVISIONAL

Source sequence(s)

AL929577

Consensus CDS

CCDS38766.1

UniProtKB/Swiss-Prot

Q80ZQ9, Q8BWF9

Related

ENSMUSP00000047275.6, ENSMUST00000045368.12

Conserved Domains (1) summary

cl11404
Location:123 → 183

Biotinyl_lipoyl_domains; Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl, ...