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Leprot leptin receptor overlapping transcript [ Mus musculus (house mouse) ]

Gene ID: 230514, updated on 21-Apr-2024

Summary

Official Symbol
Leprotprovided by MGI
Official Full Name
leptin receptor overlapping transcriptprovided by MGI
Primary source
MGI:MGI:2687005
See related
Ensembl:ENSMUSG00000035212 AllianceGenome:MGI:2687005
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
LEPR; VPS55; Obrgrp; OB-RGRP
Summary
Predicted to enable signaling receptor binding activity. Predicted to be involved in late endosome to vacuole transport via multivesicular body sorting pathway; negative regulation of protein localization to cell surface; and negative regulation of signal transduction. Predicted to be located in Golgi apparatus. Predicted to be active in endosome. Is expressed in central nervous system; retina inner nuclear layer; retina nuclear layer; and retina outer nuclear layer. Orthologous to human LEPROT (leptin receptor overlapping transcript). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 58.2), lung adult (RPKM 39.9) and 28 other tissues See more
Orthologs
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Genomic context

Location:
4 C6; 4 46.94 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (101504922..101516561)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (101647783..101659364)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_10910 Neighboring gene adenylate kinase 4 Neighboring gene STARR-seq mESC enhancer starr_10915 Neighboring gene DnaJ heat shock protein family (Hsp40) member C6 Neighboring gene predicted gene, 36012 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:101319917-101320026 Neighboring gene STARR-positive B cell enhancer ABC_E2698 Neighboring gene STARR-seq mESC enhancer starr_10917 Neighboring gene leptin receptor Neighboring gene STARR-seq mESC enhancer starr_10918 Neighboring gene PRAME like 17

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (2) 

General protein information

Preferred Names
leptin receptor gene-related protein
Names
OB-R gene-related protein
endospanin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001419413.1NP_001406342.1  leptin receptor gene-related protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL929373, BX323551
    Related
    ENSMUSP00000102540.2, ENSMUST00000106927.2
  2. NM_175036.5NP_778201.1  leptin receptor gene-related protein isoform 1

    See identical proteins and their annotated locations for NP_778201.1

    Status: VALIDATED

    Source sequence(s)
    AL929373, BX323551
    Consensus CDS
    CCDS18396.1
    UniProtKB/Swiss-Prot
    A2AV64, O89013, Q3TGT4, Q3TWZ2, Q545G9, Q91Z23
    Related
    ENSMUSP00000030254.9, ENSMUST00000030254.15
    Conserved Domains (1) summary
    pfam04133
    Location:7124
    Vps55; Vacuolar protein sorting 55

RNA

  1. NR_185080.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL929373, BX323551

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    101504922..101516561
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)