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Efcab14 EF-hand calcium binding domain 14 [ Mus musculus (house mouse) ]

Gene ID: 230648, updated on 5-Mar-2024

Summary

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Official Symbol
Efcab14provided by MGI
Official Full Name
EF-hand calcium binding domain 14provided by MGI
Primary source
MGI:MGI:2442397
See related
Ensembl:ENSMUSG00000034210 AllianceGenome:MGI:2442397
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4732418C07Rik
Summary
Predicted to enable metal ion binding activity. Is expressed in several structures, including genitourinary system; gut gland; liver and biliary system; nervous system; and retina nuclear layer. Orthologous to human EFCAB14 (EF-hand calcium binding domain 14). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 10.8), adrenal adult (RPKM 10.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 D1; 4 53.06 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (115594914..115634590)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (115737716..115777393)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 4, subfamily b, polypeptide 1 Neighboring gene eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) pseudogene Neighboring gene testis expressed 38 Neighboring gene ATP synthase mitochondrial F1 complex assembly factor 1 Neighboring gene STARR-seq mESC enhancer starr_11125 Neighboring gene MOB kinase activator 3C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A STUB1 ubiquitin ligase/CHIC2 protein complex negatively regulates the IL-3, IL-5, and GM-CSF cytokine receptor common β chain (CSF2RB) protein stability. Koochaki SHJ, et al. J Biol Chem, 2022 Oct. PMID 36108743, Free PMC Article
  2. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article
  3. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  4. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  5. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0494

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
EF-hand calcium-binding domain-containing protein 14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368627.1 → NP_001355556.1  EF-hand calcium-binding domain-containing protein 14 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK028618, AL626806
    Consensus CDS
    CCDS89810.1
    UniProtKB/Swiss-Prot
    A2A8U1, Q3TQN6, Q8BGQ6, Q8BJV7, Q8C0R1
    UniProtKB/TrEMBL
    Q3V1D2
    Related
    ENSMUSP00000102135.3, ENSMUST00000106525.9
    Conserved Domains (1) summary
    COG1196
    Location:97 → 331
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  2. NM_172698.2 → NP_766286.2  EF-hand calcium-binding domain-containing protein 14 isoform 1

    See identical proteins and their annotated locations for NP_766286.2

    Status: VALIDATED

    Source sequence(s)
    BC059213
    Consensus CDS
    CCDS18494.1
    UniProtKB/TrEMBL
    Q3V1D2, Q6PCQ6
    Related
    ENSMUSP00000074025.7, ENSMUST00000074425.13
    Conserved Domains (1) summary
    COG1196
    Location:97 → 333
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    115594914..115634590
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164033.1 → XP_036019926.1  EF-hand calcium-binding domain-containing protein 14 isoform X3

    UniProtKB/TrEMBL
    Q3V1D2
    Related
    ENSMUSP00000102134.4, ENSMUST00000106524.4

  2. XM_036164034.1 → XP_036019927.1  EF-hand calcium-binding domain-containing protein 14 isoform X4

    UniProtKB/TrEMBL
    Q3V1D2
    Conserved Domains (1) summary
    TIGR04523
    Location:97 → 376
    Mplasa_alph_rch; helix-rich Mycoplasma protein

  3. XM_036164032.1 → XP_036019925.1  EF-hand calcium-binding domain-containing protein 14 isoform X1

    UniProtKB/TrEMBL
    Q3V1D2
    Conserved Domains (1) summary
    TIGR04523
    Location:97 → 376
    Mplasa_alph_rch; helix-rich Mycoplasma protein

  4. XM_006503006.5 → XP_006503069.1  EF-hand calcium-binding domain-containing protein 14 isoform X2

    See identical proteins and their annotated locations for XP_006503069.1

    UniProtKB/Swiss-Prot
    A2A8U1, Q3TQN6, Q8BGQ6, Q8BJV7, Q8C0R1
    UniProtKB/TrEMBL
    Q3V1D2
    Related
    ENSMUSP00000102132.3, ENSMUST00000106522.9
    Conserved Domains (1) summary
    COG1196
    Location:97 → 331
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BGQ6.1 GenPept UniProtKB/Swiss-Prot:Q8BGQ6

Gene LinkOut

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