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RRP1B ribosomal RNA processing 1B [ Homo sapiens (human) ]

Gene ID: 23076, updated on 5-Sep-2021

Summary

Official Symbol
RRP1Bprovided by HGNC
Official Full Name
ribosomal RNA processing 1Bprovided by HGNC
Primary source
HGNC:HGNC:23818
See related
Ensembl:ENSG00000160208 MIM:610654
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Nnp1; RRP1; NNP1L; KIAA0179; PPP1R136
Expression
Ubiquitous expression in lymph node (RPKM 10.6), testis (RPKM 10.3) and 25 other tissues See more
Orthologs
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Genomic context

See RRP1B in Genome Data Viewer
Location:
21q22.3
Exon count:
16
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 21 NC_000021.9 (43659560..43696079)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (45079441..45115960)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene heat shock transcription factor 2 binding protein Neighboring gene H2B.S histone 1 Neighboring gene microRNA 6070 Neighboring gene RRP1B-PDXK intergenic CAGE-defined mid-level expression enhancer Neighboring gene uncharacterized LOC105372824 Neighboring gene pyridoxal kinase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association analysis of eosinophilic esophagitis provides insight into the tissue specificity of this allergic disease.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0179

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription coactivator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
 
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to virus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation by host of viral transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in rRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of RNA splicing ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in chromosome IDA
Inferred from Direct Assay
more info
 
located_in cytosol HDA PubMed 
located_in granular component IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of preribosome, large subunit precursor IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of preribosome, small subunit precursor IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ribosomal RNA processing protein 1 homolog B
Names
RRP1-like protein B
protein phosphatase 1, regulatory subunit 136
ribosomal RNA processing 1 homolog B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015056.3NP_055871.1  ribosomal RNA processing protein 1 homolog B

    See identical proteins and their annotated locations for NP_055871.1

    Status: VALIDATED

    Source sequence(s)
    AK056263, AK124620, AP001052, BC028386, BE544027, BX479134
    Consensus CDS
    CCDS33577.1
    UniProtKB/Swiss-Prot
    Q14684
    Related
    ENSP00000339145.4, ENST00000340648.6
    Conserved Domains (1) summary
    pfam05997
    Location:10218
    Nop52; Nucleolar protein,Nop52

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p13 Primary Assembly

    Range
    43659560..43696079
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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