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Agbl5 ATP/GTP binding protein-like 5 [ Mus musculus (house mouse) ]

Gene ID: 231093, updated on 5-Mar-2024

Summary

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Official Symbol
Agbl5provided by MGI
Official Full Name
ATP/GTP binding protein-like 5provided by MGI
Primary source
MGI:MGI:2441745
See related
Ensembl:ENSMUSG00000029165 AllianceGenome:MGI:2441745
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CCP5; 9430057O19Rik
Summary
Enables metallocarboxypeptidase activity and tubulin binding activity. Involved in defense response to virus and protein branching point deglutamylation. Located in cytosol and nucleus. Human ortholog(s) of this gene implicated in retinitis pigmentosa 75. Orthologous to human AGBL5 (AGBL carboxypeptidase 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 119.1), limb E14.5 (RPKM 12.0) and 6 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 B1; 5 16.9 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (31045321..31064008)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (30888639..30906666)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene microtubule-associated protein, RP/EB family, member 3 Neighboring gene STARR-positive B cell enhancer ABC_E10311 Neighboring gene STARR-seq mESC enhancer starr_12763 Neighboring gene transmembrane protein 214 Neighboring gene nuclear encoded tRNA alanine 15 (anticodon AGC) Neighboring gene predicted gene, 35795 Neighboring gene nuclear encoded tRNA tyrosine 9 (anticodon GTA) Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:31218364-31218473 Neighboring gene oligosaccharyltransferase complex subunit 4 (non-catalytic) Neighboring gene elastin microfibril interfacer 1 Neighboring gene STARR-positive B cell enhancer ABC_E4749 Neighboring gene ketohexokinase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Loss of the deglutamylase CCP5 perturbs multiple steps of spermatogenesis and leads to male infertility. Giordano T, et al. J Cell Sci, 2019 Feb 7. PMID 30635446
  2. Role of Cytosolic Carboxypeptidase 5 in Neuronal Survival and Spermatogenesis. Wu HY, et al. Sci Rep, 2017 Jan 27. PMID 28128286, Free PMC Article
  3. Cytosolic carboxypeptidase 5 removes α- and γ-linked glutamates from tubulin. Berezniuk I, et al. J Biol Chem, 2013 Oct 18. PMID 24022482, Free PMC Article
  4. Identification of tubulin deglutamylase among Caenorhabditis elegans and mammalian cytosolic carboxypeptidases (CCPs). Kimura Y, et al. J Biol Chem, 2010 Jul 23. PMID 20519502, Free PMC Article
  5. A novel subfamily of mouse cytosolic carboxypeptidases. Kalinina E, et al. FASEB J, 2007 Mar. PMID 17244818

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Loss of the deglutamylase CCP5 perturbs multiple steps of spermatogenesis and leads to male infertility.
    Title: Loss of the deglutamylase CCP5 perturbs multiple steps of spermatogenesis and leads to male infertility.
  2. Nna1 and CCP5 do not work coordinately in the same pathway in either the nervous system or spermatogenesis.
    Title: Role of Cytosolic Carboxypeptidase 5 in Neuronal Survival and Spermatogenesis.
  3. CCP5 functions as a dual-functional deglutamylase cleaving both alpha- and gamma-linked glutamate from tubulin.
    Title: Cytosolic carboxypeptidase 5 removes α- and γ-linked glutamates from tubulin.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Clone Names

  • 4930455N08

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metallocarboxypeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metallocarboxypeptidase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables metallocarboxypeptidase activity TAS
Traceable Author Statement
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables tubulin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in C-terminal protein deglutamylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in defense response to virus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein branching point deglutamylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein branching point deglutamylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein deglutamylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein deglutamylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein side chain deglutamylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in midbody ISO
Inferred from Sequence Orthology
more info
  
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cytosolic carboxypeptidase-like protein 5
Names
carboxypeptidase 5, cytosolic
protein deglutamylase CCP5
NP_001041657.1
NP_001281191.1
NP_001361666.1
NP_001395007.1
NP_001395008.1
NP_001395009.1
NP_001395010.1
NP_001395011.1
NP_001395012.1
NP_001395013.1
NP_001395014.1
NP_001395015.1
NP_001395016.1
NP_777274.1
XP_006503930.3
XP_006503931.3
XP_006503933.1
XP_006503934.1
XP_006503935.1
XP_006503936.3
XP_006503938.1
XP_006503939.1
XP_006503940.1
XP_036020907.1
XP_036020908.1
XP_036020909.1
XP_036020910.1
XP_036020911.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001048192.3 → NP_001041657.1  cytosolic carboxypeptidase-like protein 5 isoform 3

    See identical proteins and their annotated locations for NP_001041657.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) encodes the longest isoform (3).
    Source sequence(s)
    AC109606
    Consensus CDS
    CCDS39048.1
    UniProtKB/Swiss-Prot
    Q09M02
    Related
    ENSMUSP00000110348.3, ENSMUST00000114700.9
    Conserved Domains (2) summary
    cd06236
    Location:212 → 603
    M14_AGBL5_like; Peptidase M14-like domain of ATP/GTP binding protein (AGBL)-5 and related proteins
    pfam18027
    Location:10 → 122
    Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

  2. NM_001294262.2 → NP_001281191.1  cytosolic carboxypeptidase-like protein 5 isoform 6

    See identical proteins and their annotated locations for NP_001281191.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) contains a 3' terminal exon that extends past a splice site that is used in variant 3. This results in a novel 3' coding region and 3' UTR, compared to variant 3. It encodes isoform 6 which is shorter and has a distinct C-terminus, compared to isoform 3.
    Source sequence(s)
    AC109606
    Consensus CDS
    CCDS80242.1
    UniProtKB/Swiss-Prot
    Q09M02
    Related
    ENSMUSP00000144018.2, ENSMUST00000202060.4
    Conserved Domains (1) summary
    cd06236
    Location:176 → 568
    M14_AGBL5_like; Peptidase M14-like domain of ATP/GTP binding protein (AGBL)-5 and related proteins

  3. NM_001374737.2 → NP_001361666.1  cytosolic carboxypeptidase-like protein 5 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC109606
    Consensus CDS
    CCDS89898.1
    Related
    ENSMUSP00000144188.2, ENSMUST00000201917.4
    Conserved Domains (2) summary
    cd06236
    Location:183 → 574
    M14_AGBL5_like; Peptidase M14-like domain of ATP/GTP binding protein (AGBL)-5 and related proteins
    pfam18027
    Location:10 → 155
    Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

  4. NM_001408078.1 → NP_001395007.1  cytosolic carboxypeptidase-like protein 5 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC109606

  5. NM_001408079.1 → NP_001395008.1  cytosolic carboxypeptidase-like protein 5 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC109606

  6. NM_001408080.1 → NP_001395009.1  cytosolic carboxypeptidase-like protein 5 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC109606

  7. NM_001408081.1 → NP_001395010.1  cytosolic carboxypeptidase-like protein 5 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC109606
    Related
    ENSMUSP00000143934.2, ENSMUST00000201225.4

  8. NM_001408082.1 → NP_001395011.1  cytosolic carboxypeptidase-like protein 5 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC109606

  9. NM_001408083.1 → NP_001395012.1  cytosolic carboxypeptidase-like protein 5 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC109606
    Related
    ENSMUST00000201918.4

  10. NM_001408084.1 → NP_001395013.1  cytosolic carboxypeptidase-like protein 5 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC109606

  11. NM_001408085.1 → NP_001395014.1  cytosolic carboxypeptidase-like protein 5 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC109606

  12. NM_001408086.1 → NP_001395015.1  cytosolic carboxypeptidase-like protein 5 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC109606

  13. NM_001408087.1 → NP_001395016.1  cytosolic carboxypeptidase-like protein 5 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC109606

  14. NM_174849.4 → NP_777274.1  cytosolic carboxypeptidase-like protein 5 isoform 5

    See identical proteins and their annotated locations for NP_777274.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) has multiple differences, compared to variant 3. The resulting protein (isoform 5), has a shorter and distinct C-terminus when it is compared to isoform 3.
    Source sequence(s)
    AC109606
    Consensus CDS
    CCDS19165.1
    UniProtKB/Swiss-Prot
    Q09M02
    Related
    ENSMUSP00000063228.5, ENSMUST00000069705.11
    Conserved Domains (1) summary
    cd06236
    Location:176 → 568
    M14_AGBL5_like; Peptidase M14-like domain of ATP/GTP binding protein (AGBL)-5 and related proteins

RNA

  1. NR_122116.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) lacks an alternate internal exon and uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 3, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC109606
    Related
    ENSMUST00000201817.4

  2. NR_122117.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 3, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC109606
    Related
    ENSMUST00000202757.4

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    31045321..31064008
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165015.1 → XP_036020908.1  cytosolic carboxypeptidase-like protein 5 isoform X4

    Conserved Domains (2) summary
    cd06236
    Location:304 → 695
    M14_AGBL5_like; Peptidase M14-like domain of ATP/GTP binding protein (AGBL)-5 and related proteins
    pfam18027
    Location:102 → 214
    Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

  2. XM_006503868.5 → XP_006503931.3  cytosolic carboxypeptidase-like protein 5 isoform X3

    Conserved Domains (2) summary
    cd06236
    Location:304 → 695
    M14_AGBL5_like; Peptidase M14-like domain of ATP/GTP binding protein (AGBL)-5 and related proteins
    pfam18027
    Location:102 → 214
    Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

  3. XM_036165014.1 → XP_036020907.1  cytosolic carboxypeptidase-like protein 5 isoform X1

    Conserved Domains (2) summary
    cd06236
    Location:304 → 695
    M14_AGBL5_like; Peptidase M14-like domain of ATP/GTP binding protein (AGBL)-5 and related proteins
    pfam18027
    Location:102 → 214
    Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

  4. XM_036165018.1 → XP_036020911.1  cytosolic carboxypeptidase-like protein 5 isoform X10

    Conserved Domains (2) summary
    cd06236
    Location:275 → 666
    M14_AGBL5_like; Peptidase M14-like domain of ATP/GTP binding protein (AGBL)-5 and related proteins
    pfam18027
    Location:102 → 247
    Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

  5. XM_036165016.1 → XP_036020909.1  cytosolic carboxypeptidase-like protein 5 isoform X7

    Conserved Domains (2) summary
    cd06236
    Location:275 → 666
    M14_AGBL5_like; Peptidase M14-like domain of ATP/GTP binding protein (AGBL)-5 and related proteins
    pfam18027
    Location:102 → 247
    Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

  6. XM_006503873.5 → XP_006503936.3  cytosolic carboxypeptidase-like protein 5 isoform X6

    Conserved Domains (2) summary
    cd06236
    Location:275 → 666
    M14_AGBL5_like; Peptidase M14-like domain of ATP/GTP binding protein (AGBL)-5 and related proteins
    pfam18027
    Location:102 → 247
    Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

  7. XM_006503867.5 → XP_006503930.3  cytosolic carboxypeptidase-like protein 5 isoform X2

    Conserved Domains (2) summary
    cd06236
    Location:275 → 666
    M14_AGBL5_like; Peptidase M14-like domain of ATP/GTP binding protein (AGBL)-5 and related proteins
    pfam18027
    Location:102 → 247
    Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

  8. XM_006503877.3 → XP_006503940.1  cytosolic carboxypeptidase-like protein 5 isoform X8

    See identical proteins and their annotated locations for XP_006503940.1

    UniProtKB/Swiss-Prot
    D3Z6S8, Q09M01, Q09M02, Q09M03, Q09M04, Q6PFZ3, Q8BLL9, Q8BM52, Q8BZD8, Q8C0W4
    Conserved Domains (2) summary
    cd06236
    Location:183 → 574
    M14_AGBL5_like; Peptidase M14-like domain of ATP/GTP binding protein (AGBL)-5 and related proteins
    pfam18027
    Location:10 → 155
    Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

  9. XM_006503872.3 → XP_006503935.1  cytosolic carboxypeptidase-like protein 5 isoform X5

    See identical proteins and their annotated locations for XP_006503935.1

    Conserved Domains (2) summary
    cd06236
    Location:212 → 603
    M14_AGBL5_like; Peptidase M14-like domain of ATP/GTP binding protein (AGBL)-5 and related proteins
    pfam18027
    Location:10 → 122
    Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

  10. XM_006503871.3 → XP_006503934.1  cytosolic carboxypeptidase-like protein 5 isoform X5

    See identical proteins and their annotated locations for XP_006503934.1

    Conserved Domains (2) summary
    cd06236
    Location:212 → 603
    M14_AGBL5_like; Peptidase M14-like domain of ATP/GTP binding protein (AGBL)-5 and related proteins
    pfam18027
    Location:10 → 122
    Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

  11. XM_006503875.3 → XP_006503938.1  cytosolic carboxypeptidase-like protein 5 isoform X8

    See identical proteins and their annotated locations for XP_006503938.1

    UniProtKB/Swiss-Prot
    D3Z6S8, Q09M01, Q09M02, Q09M03, Q09M04, Q6PFZ3, Q8BLL9, Q8BM52, Q8BZD8, Q8C0W4
    Conserved Domains (2) summary
    cd06236
    Location:183 → 574
    M14_AGBL5_like; Peptidase M14-like domain of ATP/GTP binding protein (AGBL)-5 and related proteins
    pfam18027
    Location:10 → 155
    Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

  12. XM_006503876.3 → XP_006503939.1  cytosolic carboxypeptidase-like protein 5 isoform X8

    See identical proteins and their annotated locations for XP_006503939.1

    UniProtKB/Swiss-Prot
    D3Z6S8, Q09M01, Q09M02, Q09M03, Q09M04, Q6PFZ3, Q8BLL9, Q8BM52, Q8BZD8, Q8C0W4
    Related
    ENSMUSP00000143808.2, ENSMUST00000201168.4
    Conserved Domains (2) summary
    cd06236
    Location:183 → 574
    M14_AGBL5_like; Peptidase M14-like domain of ATP/GTP binding protein (AGBL)-5 and related proteins
    pfam18027
    Location:10 → 155
    Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

  13. XM_006503870.3 → XP_006503933.1  cytosolic carboxypeptidase-like protein 5 isoform X5

    See identical proteins and their annotated locations for XP_006503933.1

    Conserved Domains (2) summary
    cd06236
    Location:212 → 603
    M14_AGBL5_like; Peptidase M14-like domain of ATP/GTP binding protein (AGBL)-5 and related proteins
    pfam18027
    Location:10 → 122
    Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

  14. XM_036165017.1 → XP_036020910.1  cytosolic carboxypeptidase-like protein 5 isoform X8

    UniProtKB/Swiss-Prot
    D3Z6S8, Q09M01, Q09M02, Q09M03, Q09M04, Q6PFZ3, Q8BLL9, Q8BM52, Q8BZD8, Q8C0W4
    Conserved Domains (2) summary
    cd06236
    Location:183 → 574
    M14_AGBL5_like; Peptidase M14-like domain of ATP/GTP binding protein (AGBL)-5 and related proteins
    pfam18027
    Location:10 → 155
    Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001048190.1: Suppressed sequence

    Description
    NM_001048190.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.

  2. NM_001048191.1: Suppressed sequence

    Description
    NM_001048191.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q09M02.2 GenPept UniProtKB/Swiss-Prot:Q09M02

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