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Agbl5 ATP/GTP binding protein-like 5 [ Mus musculus (house mouse) ]

Gene ID: 231093, updated on 8-Jul-2021

Summary

Official Symbol
Agbl5provided by MGI
Official Full Name
ATP/GTP binding protein-like 5provided by MGI
Primary source
MGI:MGI:2441745
See related
Ensembl:ENSMUSG00000029165
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ccp; CCP5; 9430057O19Rik
Expression
Biased expression in testis adult (RPKM 119.1), limb E14.5 (RPKM 12.0) and 6 other tissues See more
Orthologs
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Genomic context

See Agbl5 in Genome Data Viewer
Location:
5; 5 B1
Exon count:
20
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (31045321..31064010)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (30888639..30906666)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (31191225..31209039)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46907 Neighboring gene microtubule-associated protein, RP/EB family, member 3 Neighboring gene transmembrane protein 214 Neighboring gene nuclear encoded tRNA alanine 15 (anticodon AGC) Neighboring gene predicted gene, 35795 Neighboring gene nuclear encoded tRNA tyrosine 9 (anticodon GTA) Neighboring gene oligosaccharyltransferase complex subunit 4 (non-catalytic) Neighboring gene elastin microfibril interfacer 1 Neighboring gene ketohexokinase

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Homology

Clone Names

  • 4930455N08

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metallocarboxypeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables metallocarboxypeptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables metallocarboxypeptidase activity TAS
Traceable Author Statement
more info
 
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables tubulin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in defense response to virus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein branching point deglutamylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein deglutamylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein deglutamylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein side chain deglutamylation TAS
Traceable Author Statement
more info
 
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
 
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in midbody ISO
Inferred from Sequence Orthology
more info
 
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
cytosolic carboxypeptidase-like protein 5
Names
carboxypeptidase 5, cytosolic
NP_001041657.1
NP_001281191.1
NP_001361666.1
NP_777274.1
XP_006503930.3
XP_006503931.3
XP_006503933.1
XP_006503934.1
XP_006503935.1
XP_006503936.3
XP_006503938.1
XP_006503939.1
XP_006503940.1
XP_030110238.1
XP_036020907.1
XP_036020908.1
XP_036020909.1
XP_036020910.1
XP_036020911.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001048192.2NP_001041657.1  cytosolic carboxypeptidase-like protein 5 isoform 3

    See identical proteins and their annotated locations for NP_001041657.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) encodes the longest isoform (3).
    Source sequence(s)
    DQ867036
    Consensus CDS
    CCDS39048.1
    UniProtKB/Swiss-Prot
    Q09M02
    Related
    ENSMUSP00000110348.3, ENSMUST00000114700.9
    Conserved Domains (2) summary
    cd06236
    Location:212603
    M14_AGBL5_like; Peptidase M14-like domain of ATP/GTP binding protein (AGBL)-5 and related proteins
    pfam18027
    Location:10122
    Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain
  2. NM_001294262.1NP_001281191.1  cytosolic carboxypeptidase-like protein 5 isoform 6

    See identical proteins and their annotated locations for NP_001281191.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) contains a 3' terminal exon that extends past a splice site that is used in variant 3. This results in a novel 3' coding region and 3' UTR, compared to variant 3. It encodes isoform 6 which is shorter and has a distinct C-terminus, compared to isoform 3.
    Source sequence(s)
    AK029676, AK034894, BY100231
    Consensus CDS
    CCDS80242.1
    UniProtKB/Swiss-Prot
    Q09M02
    Related
    ENSMUSP00000144018.2, ENSMUST00000202060.4
    Conserved Domains (1) summary
    cd06236
    Location:176568
    M14_AGBL5_like; Peptidase M14-like domain of ATP/GTP binding protein (AGBL)-5 and related proteins
  3. NM_001374737.1NP_001361666.1  cytosolic carboxypeptidase-like protein 5 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC109606
    Consensus CDS
    CCDS89898.1
    Related
    ENSMUSP00000144188.2, ENSMUST00000201917.4
    Conserved Domains (2) summary
    cd06236
    Location:183574
    M14_AGBL5_like; Peptidase M14-like domain of ATP/GTP binding protein (AGBL)-5 and related proteins
    pfam18027
    Location:10155
    Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain
  4. NM_174849.3NP_777274.1  cytosolic carboxypeptidase-like protein 5 isoform 5

    See identical proteins and their annotated locations for NP_777274.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) has multiple differences, compared to variant 3. The resulting protein (isoform 5), has a shorter and distinct C-terminus when it is compared to isoform 3.
    Source sequence(s)
    AK029676
    Consensus CDS
    CCDS19165.1
    UniProtKB/Swiss-Prot
    Q09M02
    Related
    ENSMUSP00000063228.5, ENSMUST00000069705.11
    Conserved Domains (1) summary
    cd06236
    Location:176568
    M14_AGBL5_like; Peptidase M14-like domain of ATP/GTP binding protein (AGBL)-5 and related proteins

RNA

  1. NR_122116.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) lacks an alternate internal exon and uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 3, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BC057349, BY089079
    Related
    ENSMUST00000201817.4
  2. NR_122117.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 3, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC109606
    Related
    ENSMUST00000202757.4

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    31045321..31064010
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165015.1XP_036020908.1  cytosolic carboxypeptidase-like protein 5 isoform X4

    Conserved Domains (2) summary
    cd06236
    Location:304695
    M14_AGBL5_like; Peptidase M14-like domain of ATP/GTP binding protein (AGBL)-5 and related proteins
    pfam18027
    Location:102214
    Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain
  2. XM_006503868.5XP_006503931.3  cytosolic carboxypeptidase-like protein 5 isoform X3

    Conserved Domains (2) summary
    cd06236
    Location:304695
    M14_AGBL5_like; Peptidase M14-like domain of ATP/GTP binding protein (AGBL)-5 and related proteins
    pfam18027
    Location:102214
    Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain
  3. XM_036165014.1XP_036020907.1  cytosolic carboxypeptidase-like protein 5 isoform X1

    Conserved Domains (2) summary
    cd06236
    Location:304695
    M14_AGBL5_like; Peptidase M14-like domain of ATP/GTP binding protein (AGBL)-5 and related proteins
    pfam18027
    Location:102214
    Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain
  4. XM_036165018.1XP_036020911.1  cytosolic carboxypeptidase-like protein 5 isoform X10

    Conserved Domains (2) summary
    cd06236
    Location:275666
    M14_AGBL5_like; Peptidase M14-like domain of ATP/GTP binding protein (AGBL)-5 and related proteins
    pfam18027
    Location:102247
    Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain
  5. XM_036165016.1XP_036020909.1  cytosolic carboxypeptidase-like protein 5 isoform X7

    Conserved Domains (2) summary
    cd06236
    Location:275666
    M14_AGBL5_like; Peptidase M14-like domain of ATP/GTP binding protein (AGBL)-5 and related proteins
    pfam18027
    Location:102247
    Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain
  6. XM_006503873.5XP_006503936.3  cytosolic carboxypeptidase-like protein 5 isoform X6

    Conserved Domains (2) summary
    cd06236
    Location:275666
    M14_AGBL5_like; Peptidase M14-like domain of ATP/GTP binding protein (AGBL)-5 and related proteins
    pfam18027
    Location:102247
    Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain
  7. XM_006503867.5XP_006503930.3  cytosolic carboxypeptidase-like protein 5 isoform X2

    Conserved Domains (2) summary
    cd06236
    Location:275666
    M14_AGBL5_like; Peptidase M14-like domain of ATP/GTP binding protein (AGBL)-5 and related proteins
    pfam18027
    Location:102247
    Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain
  8. XM_006503877.3XP_006503940.1  cytosolic carboxypeptidase-like protein 5 isoform X8

    See identical proteins and their annotated locations for XP_006503940.1

    UniProtKB/Swiss-Prot
    Q09M02
    Conserved Domains (2) summary
    cd06236
    Location:183574
    M14_AGBL5_like; Peptidase M14-like domain of ATP/GTP binding protein (AGBL)-5 and related proteins
    pfam18027
    Location:10155
    Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain
  9. XM_006503872.3XP_006503935.1  cytosolic carboxypeptidase-like protein 5 isoform X5

    See identical proteins and their annotated locations for XP_006503935.1

    Conserved Domains (2) summary
    cd06236
    Location:212603
    M14_AGBL5_like; Peptidase M14-like domain of ATP/GTP binding protein (AGBL)-5 and related proteins
    pfam18027
    Location:10122
    Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain
  10. XM_006503871.3XP_006503934.1  cytosolic carboxypeptidase-like protein 5 isoform X5

    See identical proteins and their annotated locations for XP_006503934.1

    Conserved Domains (2) summary
    cd06236
    Location:212603
    M14_AGBL5_like; Peptidase M14-like domain of ATP/GTP binding protein (AGBL)-5 and related proteins
    pfam18027
    Location:10122
    Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain
  11. XM_006503875.3XP_006503938.1  cytosolic carboxypeptidase-like protein 5 isoform X8

    See identical proteins and their annotated locations for XP_006503938.1

    UniProtKB/Swiss-Prot
    Q09M02
    Conserved Domains (2) summary
    cd06236
    Location:183574
    M14_AGBL5_like; Peptidase M14-like domain of ATP/GTP binding protein (AGBL)-5 and related proteins
    pfam18027
    Location:10155
    Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain
  12. XM_006503876.3XP_006503939.1  cytosolic carboxypeptidase-like protein 5 isoform X8

    See identical proteins and their annotated locations for XP_006503939.1

    UniProtKB/Swiss-Prot
    Q09M02
    Related
    ENSMUSP00000143808.2, ENSMUST00000201168.4
    Conserved Domains (2) summary
    cd06236
    Location:183574
    M14_AGBL5_like; Peptidase M14-like domain of ATP/GTP binding protein (AGBL)-5 and related proteins
    pfam18027
    Location:10155
    Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain
  13. XM_030254378.2XP_030110238.1  cytosolic carboxypeptidase-like protein 5 isoform X9

    Conserved Domains (2) summary
    cd06236
    Location:212603
    M14_AGBL5_like; Peptidase M14-like domain of ATP/GTP binding protein (AGBL)-5 and related proteins
    pfam18027
    Location:10122
    Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain
  14. XM_006503870.3XP_006503933.1  cytosolic carboxypeptidase-like protein 5 isoform X5

    See identical proteins and their annotated locations for XP_006503933.1

    Conserved Domains (2) summary
    cd06236
    Location:212603
    M14_AGBL5_like; Peptidase M14-like domain of ATP/GTP binding protein (AGBL)-5 and related proteins
    pfam18027
    Location:10122
    Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain
  15. XM_036165017.1XP_036020910.1  cytosolic carboxypeptidase-like protein 5 isoform X8

    Conserved Domains (2) summary
    cd06236
    Location:183574
    M14_AGBL5_like; Peptidase M14-like domain of ATP/GTP binding protein (AGBL)-5 and related proteins
    pfam18027
    Location:10155
    Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001048190.1: Suppressed sequence

    Description
    NM_001048190.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
  2. NM_001048191.1: Suppressed sequence

    Description
    NM_001048191.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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