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Sds serine dehydratase [ Mus musculus (house mouse) ]

Gene ID: 231691, updated on 6-May-2021

Summary

Official Symbol
Sdsprovided by MGI
Official Full Name
serine dehydrataseprovided by MGI
Primary source
MGI:MGI:98270
See related
Ensembl:ENSMUSG00000029597
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SD; SDH; 4432411H13Rik
Expression
Restricted expression toward liver adult (RPKM 181.2) See more
Orthologs
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Genomic context

See Sds in Genome Data Viewer
Location:
5; 5 F
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (120614612..120621997)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (120476547..120483932)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (120926556..120933914)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene LIM homeobox protein 5 Neighboring gene serine dehydratase-like Neighboring gene phospholipase B domain containing 2 Neighboring gene solute carrier family 8 (sodium/lithium/calcium exchanger), member B1 Neighboring gene two pore channel 1 Neighboring gene IQ motif containing D

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3) 

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables L-serine ammonia-lyase activity ISO
Inferred from Sequence Orthology
more info
 
enables L-threonine ammonia-lyase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables pyridoxal phosphate binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in L-serine catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular amino acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within gluconeogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in isoleucine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in pyruvate biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in threonine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
L-serine dehydratase/L-threonine deaminase
Names
L-serine deaminase
L-threonine dehydratase
TDH
NP_663540.1
XP_006530361.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145565.1NP_663540.1  L-serine dehydratase/L-threonine deaminase

    See identical proteins and their annotated locations for NP_663540.1

    Status: PROVISIONAL

    Source sequence(s)
    BC021950
    Consensus CDS
    CCDS19619.1
    UniProtKB/Swiss-Prot
    Q8VBT2
    UniProtKB/TrEMBL
    Q3UEN6
    Related
    ENSMUSP00000064849.8, ENSMUST00000066540.14
    Conserved Domains (2) summary
    cd06448
    Location:10320
    L-Ser-dehyd; Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- , D-serine, or L-threonine to pyruvate/ketobutyrate and ammonia.
    pfam00291
    Location:10304
    PALP; Pyridoxal-phosphate dependent enzyme

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    120614612..120621997
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530298.4XP_006530361.1  L-serine dehydratase/L-threonine deaminase isoform X1

    Conserved Domains (1) summary
    cd06448
    Location:35345
    L-Ser-dehyd; Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- , D-serine, or L-threonine to pyruvate/ketobutyrate and ammonia.
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