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ZCCHC14 zinc finger CCHC-type containing 14 [ Homo sapiens (human) ]

Gene ID: 23174, updated on 3-Apr-2024

Summary

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Official Symbol
ZCCHC14provided by HGNC
Official Full Name
zinc finger CCHC-type containing 14provided by HGNC
Primary source
HGNC:HGNC:24134
See related
Ensembl:ENSG00000140948 MIM:620697; AllianceGenome:HGNC:24134
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BDG29; BDG-29
Summary
Predicted to enable nucleic acid binding activity; phosphatidylinositol binding activity; and zinc ion binding activity. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 26.9), ovary (RPKM 7.6) and 24 other tissues See more
Orthologs
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Genomic context

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Location:
16q24.2
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (87406248..87493024, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (93477129..93563941, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (87439854..87526630, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene F-box protein 31 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:87417185-87417838 Neighboring gene uncharacterized LOC124903747 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:87417839-87418490 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11321 Neighboring gene tRNA-Met (anticodon CAT) 6-1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:87424900-87425858 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7836 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7837 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11322 Neighboring gene microtubule associated protein 1 light chain 3 beta Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr16:87440788-87441987 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:87456781-87457290 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:87457291-87457798 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:87458817-87459326 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:87460343-87460850 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:87468667-87469584 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:87486642-87487142 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr16:87490779-87491978 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:87502852-87503437 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:87503438-87504022 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:87504708-87505665 Neighboring gene nuclear receptor subfamily 3 group C member 1 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7838 Neighboring gene ZCCHC14 divergent transcript Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:87552465-87553062 Neighboring gene uncharacterized LOC124903748 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:87573595-87573826 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:87575434-87575934

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. ZCCHC14 regulates proliferation and invasion of non-small cell lung cancer through the MAPK-P38 signalling pathway. Shi X, et al. J Cell Mol Med, 2021 Feb. PMID 33345444, Free PMC Article
  2. Plasma concentration of ZCCHC14 contributes to prognostic efficacy in intracerebral hemorrhage patients. Li DL, et al. Eur Rev Med Pharmacol Sci, 2019 Oct. PMID 31646585
  3. Genetic variation at 16q24.2 is associated with small vessel stroke. Traylor M, et al. Ann Neurol, 2017 Mar. PMID 27997041, Free PMC Article
  4. A Genome-wide CRISPR Screen Identifies ZCCHC14 as a Host Factor Required for Hepatitis B Surface Antigen Production. Hyrina A, et al. Cell Rep, 2019 Dec 3. PMID 31801065
  5. circRNA-ZCCHC14 affects the chondrogenic differentiation ability of peripheral blood-derived mesenchymal stem cells by regulating GREM1 through miR-181a. Zhao D, et al. Sci Rep, 2023 Feb 18. PMID 36804426, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. circRNA-ZCCHC14 affects the chondrogenic differentiation ability of peripheral blood-derived mesenchymal stem cells by regulating GREM1 through miR-181a.
    Title: circRNA-ZCCHC14 affects the chondrogenic differentiation ability of peripheral blood-derived mesenchymal stem cells by regulating GREM1 through miR-181a.
  2. The ZCCHC14/TENT4 complex is required for hepatitis A virus RNA synthesis.
    Title: The ZCCHC14/TENT4 complex is required for hepatitis A virus RNA synthesis.
  3. ZCCHC14 regulates proliferation and invasion of non-small cell lung cancer through the MAPK-P38 signalling pathway.
    Title: ZCCHC14 regulates proliferation and invasion of non-small cell lung cancer through the MAPK-P38 signalling pathway.
  4. Plasma concentration of ZCCHC14 contributes to prognostic efficacy in intracerebral hemorrhage patients.
    Title: Plasma concentration of ZCCHC14 contributes to prognostic efficacy in intracerebral hemorrhage patients.
  5. Viral hijacking of the TENT4-ZCCHC14 complex protects viral RNAs via mixed tailing.
    Title: Viral hijacking of the TENT4-ZCCHC14 complex protects viral RNAs via mixed tailing.
  6. A Genome-wide CRISPR Screen Identifies ZCCHC14 as a Host Factor Required for Hepatitis B Surface Antigen Production.
    Title: A Genome-wide CRISPR Screen Identifies ZCCHC14 as a Host Factor Required for Hepatitis B Surface Antigen Production.
  7. ZCCHC14 expression is associated with small vessel disease.
    Title: Genetic variation at 16q24.2 is associated with small vessel stroke.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A mega-analysis of genome-wide association studies for major depressive disorder.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of zinc finger, CCHC domain containing 14 (ZCCHC14) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC14139, MGC126527

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger CCHC domain-containing protein 14
Names
zinc finger, CCHC domain containing 14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015144.3 → NP_055959.2  zinc finger CCHC domain-containing protein 14

    Status: VALIDATED

    Source sequence(s)
    AC010531, AC092720, AC105429
    Consensus CDS
    CCDS10961.2
    UniProtKB/TrEMBL
    A0A590UJW6, A0A5F9XIK1
    Related
    ENSP00000499622.1, ENST00000671377.2
    Conserved Domains (3) summary
    cd09558
    Location:431 → 495
    SAM_ZCCH14; SAM domain of ZCCH14 subfamily
    pfam00098
    Location:1045 → 1060
    zf-CCHC; Zinc knuckle
    cl02563
    Location:256 → 339
    PX_domain; The Phox Homology domain, a phosphoinositide binding module

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    87406248..87493024 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005255858.4 → XP_005255915.3  zinc finger CCHC domain-containing protein 14 isoform X1

  2. XM_017023082.3 → XP_016878571.1  zinc finger CCHC domain-containing protein 14 isoform X2

    UniProtKB/TrEMBL
    H3BS18
    Related
    ENSP00000456499.1, ENST00000561928.1

RNA

  1. XR_243401.4 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    93477129..93563941 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054379872.1 → XP_054235847.1  zinc finger CCHC domain-containing protein 14 isoform X1

  2. XM_054379873.1 → XP_054235848.1  zinc finger CCHC domain-containing protein 14 isoform X2

RNA

  1. XR_008489065.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8WYQ9.1 GenPept UniProtKB/Swiss-Prot:Q8WYQ9

Gene LinkOut

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