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Mepce methylphosphate capping enzyme [ Mus musculus (house mouse) ]

Gene ID: 231803, updated on 11-Apr-2024

Summary

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Official Symbol
Mepceprovided by MGI
Official Full Name
methylphosphate capping enzymeprovided by MGI
Primary source
MGI:MGI:106477
See related
Ensembl:ENSMUSG00000029726 AllianceGenome:MGI:106477
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bcdin3; D5Wsu46e
Summary
Predicted to enable 7SK snRNA binding activity and RNA 5'-methyltransferase activity. Acts upstream of or within negative regulation of chromatin binding activity; negative regulation of transcription by RNA polymerase II; and positive regulation of G1/S transition of mitotic cell cycle. Predicted to be located in nucleus. Predicted to be part of 7SK snRNP. Is expressed in several structures, including adrenal gland; alimentary system; brain; early conceptus; and genitourinary system. Orthologous to human MEPCE (methylphosphate capping enzyme). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 32.4), thymus adult (RPKM 24.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 G2; 5 76.7 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (137780168..137785915, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (137781906..137786701, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 57848 Neighboring gene sperm acrosome developmental regulator Neighboring gene STARR-positive B cell enhancer ABC_E4797 Neighboring gene STARR-positive B cell enhancer ABC_E857 Neighboring gene STARR-positive B cell enhancer ABC_E1312 Neighboring gene protein phosphatase 1, regulatory subunit 35 Neighboring gene STARR-positive B cell enhancer ABC_E4798 Neighboring gene zinc finger, CW type with PWWP domain 1 Neighboring gene STARR-seq mESC enhancer starr_14656 Neighboring gene paired immunoglobin-like type 2 receptor alpha Neighboring gene paired immunoglobin-like type 2 receptor beta 1 Neighboring gene predicted gene, 36551

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cell cycle gene-specific control of transcription has a critical role in proliferation of primordial germ cells. Okamura D, et al. Genes Dev, 2012 Nov 15. PMID 23154982, Free PMC Article
  2. Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Ko MS, et al. Hum Mol Genet, 1998 Nov. PMID 9811942
  3. ATG5 is required for B cell polarization and presentation of particulate antigens. Arbogast F, et al. Autophagy, 2019 Feb. PMID 30196744, Free PMC Article
  4. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
  5. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC28888, MGC30590

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 7SK snRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables O-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA 5'-gamma-phosphate methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables S-adenosylmethionine-dependent methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables snRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA methylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within methylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of chromatin binding IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within positive regulation of G1/S transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein localization to Cajal body ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of snRNA transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in snRNA metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in snRNA modification IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in snRNA modification ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of 7SK snRNP ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
7SK snRNA methylphosphate capping enzyme
Names
bin3, bicoid-interacting 3, homolog
NP_001411556.1
NP_659162.3
XP_017176362.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001424627.1 → NP_001411556.1  7SK snRNA methylphosphate capping enzyme isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC125063

  2. NM_144913.4 → NP_659162.3  7SK snRNA methylphosphate capping enzyme isoform 1

    See identical proteins and their annotated locations for NP_659162.3

    Status: VALIDATED

    Source sequence(s)
    AC125063
    Consensus CDS
    CCDS39337.1
    UniProtKB/Swiss-Prot
    Q2YFS5, Q3U465, Q3UT64, Q8K3A9, Q91W35
    Related
    ENSMUSP00000031740.10, ENSMUST00000031740.16
    Conserved Domains (2) summary
    cd02440
    Location:423 → 593
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    pfam06859
    Location:552 → 660
    Bin3; Bicoid-interacting protein 3 (Bin3)

RNA

  1. NR_188806.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC125063

  2. NR_188808.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC125063

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    137780168..137785915 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017320873.1 → XP_017176362.1  7SK snRNA methylphosphate capping enzyme isoform X1

    Conserved Domains (2) summary
    cd02440
    Location:423 → 593
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    pfam06859
    Location:552 → 650
    Bin3; Bicoid-interacting protein 3 (Bin3)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K3A9.2 GenPept UniProtKB/Swiss-Prot:Q8K3A9

Gene LinkOut

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