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Mat2a methionine adenosyltransferase II, alpha [ Mus musculus (house mouse) ]

Gene ID: 232087, updated on 5-Jan-2022

Summary

Official Symbol
Mat2aprovided by MGI
Official Full Name
methionine adenosyltransferase II, alphaprovided by MGI
Primary source
MGI:MGI:2443731
See related
Ensembl:ENSMUSG00000053907
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MAT 2; D630045P18Rik
Summary
Enables methionine adenosyltransferase activity. Acts upstream of or within S-adenosylmethionine biosynthetic process and cellular response to leukemia inhibitory factor. Predicted to be part of methionine adenosyltransferase complex. Predicted to be active in cytosol. Is expressed in eye; gut; male reproductive gland or organ; metanephros; and nervous system. Orthologous to human MAT2A (methionine adenosyltransferase 2A). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Ubiquitous expression in CNS E14 (RPKM 103.5), whole brain E14.5 (RPKM 90.6) and 25 other tissues See more
Orthologs
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Genomic context

See Mat2a in Genome Data Viewer
Location:
6; 6 C1
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (72409779..72416539, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (72432796..72439556, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (72382793..72389552, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene vesicle-associated membrane protein 8 Neighboring gene gamma-glutamyl carboxylase Neighboring gene promoter of Mat2a antisense radiation induced circulating long non-coding RNA Neighboring gene SH2 domain containing 6 Neighboring gene capping protein (actin filament), gelsolin-like

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC6545

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables amino acid binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables methionine adenosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables methionine adenosyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables methionine adenosyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
part_of methionine adenosyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of methionine adenosyltransferase complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
S-adenosylmethionine synthase isoform type-2
Names
adoMet synthase 2
adoMet synthetase 2
methionine adenosyltransferase 2
NP_001350727.1
NP_001350728.1
NP_663544.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363798.1NP_001350727.1  S-adenosylmethionine synthase isoform type-2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK160869, BC058360
    Consensus CDS
    CCDS90059.1
    Related
    ENSMUSP00000145696.2, ENSMUST00000205335.2
    Conserved Domains (1) summary
    cl27369
    Location:16362
    S-AdoMet_synt_C; S-adenosylmethionine synthetase, C-terminal domain
  2. NM_001363799.1NP_001350728.1  S-adenosylmethionine synthase isoform type-2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AK133960, BC058360
    Consensus CDS
    CCDS90060.1
    Related
    ENSMUSP00000145603.2, ENSMUST00000206692.2
    Conserved Domains (1) summary
    cl27369
    Location:16364
    S-AdoMet_synt_C; S-adenosylmethionine synthetase, C-terminal domain
  3. NM_145569.5NP_663544.1  S-adenosylmethionine synthase isoform type-2 isoform 1

    See identical proteins and their annotated locations for NP_663544.1

    Status: VALIDATED

    Source sequence(s)
    AC116115
    Consensus CDS
    CCDS39515.1
    UniProtKB/Swiss-Prot
    Q3THS6
    UniProtKB/TrEMBL
    Q99J57
    Related
    ENSMUSP00000087118.7, ENSMUST00000059472.10
    Conserved Domains (1) summary
    PTZ00104
    Location:16395
    PTZ00104; S-adenosylmethionine synthase; Provisional

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    72409779..72416539 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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