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Slc6a1 solute carrier family 6 (neurotransmitter transporter, GABA), member 1 [ Mus musculus (house mouse) ]

Gene ID: 232333, updated on 16-Oct-2021

Summary

Official Symbol
Slc6a1provided by MGI
Official Full Name
solute carrier family 6 (neurotransmitter transporter, GABA), member 1provided by MGI
Primary source
MGI:MGI:95627
See related
Ensembl:ENSMUSG00000030310
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gabt; Gat1; XT-1; GAT-1; Gabt1; Xtrp1; GABATR; GABATHG; A730043E01
Expression
Biased expression in cerebellum adult (RPKM 126.5), frontal lobe adult (RPKM 110.5) and 5 other tissues See more
Orthologs
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Genomic context

See Slc6a1 in Genome Data Viewer
Location:
6; 6 E3
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (114259596..114294491)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (114282635..114317525)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (114232629..114267519)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 6 (neurotransmitter transporter, GABA), member 11 Neighboring gene high mobility group box 1-like pseudogene Neighboring gene predicted gene, 46972 Neighboring gene predicted gene, 38875 Neighboring gene histamine receptor H1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables gamma-aminobutyric acid transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables gamma-aminobutyric acid:sodium symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables gamma-aminobutyric acid:sodium symporter activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables sodium:chloride symporter activity ISO
Inferred from Sequence Orthology
more info
 
enables symporter activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of associative learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in chloride transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in gamma-aminobutyric acid import IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in gamma-aminobutyric acid import ISO
Inferred from Sequence Orthology
more info
 
involved_in inorganic anion import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in learning ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of synaptic transmission, GABAergic ISO
Inferred from Sequence Orthology
more info
 
involved_in neurotransmitter reuptake ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neurotransmitter transport IEA
Inferred from Electronic Annotation
more info
 
involved_in neurotransmitter transport IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of gamma-aminobutyric acid secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in response to inorganic substance ISO
Inferred from Sequence Orthology
more info
 
involved_in response to organic substance ISO
Inferred from Sequence Orthology
more info
 
involved_in response to purine-containing compound ISO
Inferred from Sequence Orthology
more info
 
involved_in response to toxic substance ISO
Inferred from Sequence Orthology
more info
 
involved_in sodium ion import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in sodium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of synapse organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell junction IEA
Inferred from Electronic Annotation
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
sodium- and chloride-dependent GABA transporter 1
Names
gamma-aminobutyric acid (GABA-A) transporter 1
solute carrier family 6 member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178703.4NP_848818.1  sodium- and chloride-dependent GABA transporter 1

    See identical proteins and their annotated locations for NP_848818.1

    Status: VALIDATED

    Source sequence(s)
    AK053883, BC059080, CB519886
    Consensus CDS
    CCDS20434.1
    UniProtKB/Swiss-Prot
    P31648
    UniProtKB/TrEMBL
    Q6PCX2
    Related
    ENSMUSP00000032454.6, ENSMUST00000032454.8
    Conserved Domains (1) summary
    cd11506
    Location:2599
    SLC6sbd_GAT1; Na(+)- and Cl(-)-dependent GABA transporter 1; solute-binding domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    114259596..114294491
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036166059.1XP_036021952.1  sodium- and chloride-dependent GABA transporter 1 isoform X1

    Related
    ENSMUSP00000145080.2, ENSMUST00000204074.2
    Conserved Domains (1) summary
    cl00456
    Location:1350
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
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