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A2ml1 alpha-2-macroglobulin like 1 [ Mus musculus (house mouse) ]

Gene ID: 232400, updated on 2-Oct-2021

Summary

Official Symbol
A2ml1provided by MGI
Official Full Name
alpha-2-macroglobulin like 1provided by MGI
Primary source
MGI:MGI:3039594
See related
Ensembl:ENSMUSG00000047228
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ovos; Ovos2
Expression
Biased expression in ovary adult (RPKM 19.2), liver E18 (RPKM 5.0) and 1 other tissue See more
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Genomic context

See A2ml1 in Genome Data Viewer
Location:
6; 6 F3
Exon count:
39
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (128516785..128577014, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (128539822..128581606, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (128489840..128531624, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene mitochondrial intermembrane space import and assembly protein 40 pseudogene Neighboring gene predicted pseudogene 8724 Neighboring gene killer cell lectin-like receptor subfamily B member 1A Neighboring gene predicted gene, 44478

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

Homology

Clone Names

  • MGC58520

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of peptidase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001179.3NP_001001179.2  ovostatin homolog precursor

    See identical proteins and their annotated locations for NP_001001179.2

    Status: VALIDATED

    Source sequence(s)
    AK138836, AK161068, AU044180
    Consensus CDS
    CCDS39651.1
    UniProtKB/Swiss-Prot
    Q3UU35
    UniProtKB/TrEMBL
    Q3TTY9
    Related
    ENSMUSP00000059426.8, ENSMUST00000060574.9
    Conserved Domains (6) summary
    cd02897
    Location:9561253
    A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
    pfam00207
    Location:736826
    A2M; Alpha-2-macroglobulin family
    pfam01835
    Location:121204
    A2M_N; MG2 domain
    pfam07677
    Location:13641447
    A2M_recep; A-macroglobulin receptor
    pfam07678
    Location:10081253
    A2M_comp; A-macroglobulin complement component
    pfam07703
    Location:450593
    A2M_N_2; Alpha-2-macroglobulin family N-terminal region

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    128516785..128577014 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_004942943.1 RNA Sequence

  2. XR_004942945.1 RNA Sequence

  3. XR_004942944.1 RNA Sequence

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