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Rerg RAS-like, estrogen-regulated, growth-inhibitor [ Mus musculus (house mouse) ]

Gene ID: 232441, updated on 3-Aug-2021

Summary

Official Symbol
Rergprovided by MGI
Official Full Name
RAS-like, estrogen-regulated, growth-inhibitorprovided by MGI
Primary source
MGI:MGI:2665139
See related
Ensembl:ENSMUSG00000030222
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Expression
Broad expression in adrenal adult (RPKM 26.0), bladder adult (RPKM 12.7) and 16 other tissues See more
Orthologs
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Genomic context

See Rerg in Genome Data Viewer
Location:
6; 6 G1
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (137031822..137147494, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (137054825..137170496, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (137003346..137119017, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene phosphodiesterase 6H, cGMP-specific, cone, gamma Neighboring gene predicted gene, 30055 Neighboring gene predicted gene, 52923 Neighboring gene predicted gene, 38914 Neighboring gene protein tyrosine phosphatase, receptor type, O Neighboring gene predicted gene, 52924 Neighboring gene epidermal growth factor receptor pathway substrate 8

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein activity IEA
Inferred from Electronic Annotation
more info
 
enables GDP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in response to hormone ISO
Inferred from Sequence Orthology
more info
 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ras-related and estrogen-regulated growth inhibitor
NP_001157684.1
NP_001157686.1
NP_871788.1
XP_036021981.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164212.1NP_001157684.1  ras-related and estrogen-regulated growth inhibitor isoform a

    See identical proteins and their annotated locations for NP_001157684.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 each encode isoform a.
    Source sequence(s)
    AC122303, AC144767, AK133734
    Consensus CDS
    CCDS20663.1
    UniProtKB/Swiss-Prot
    Q8R367
    Related
    ENSMUSP00000113105.2, ENSMUST00000117919.8
    Conserved Domains (1) summary
    cd04146
    Location:8169
    RERG_RasL11_like; Ras-related and Estrogen-Regulated Growth inhibitor (RERG) and Ras-like 11 (RasL11)-like families
  2. NM_001164214.1NP_001157686.1  ras-related and estrogen-regulated growth inhibitor isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AC122303, AC144767, AK133734
    Consensus CDS
    CCDS51942.1
    UniProtKB/Swiss-Prot
    Q8R367
    UniProtKB/TrEMBL
    E9PUF8
    Related
    ENSMUSP00000113702.2, ENSMUST00000119610.4
    Conserved Domains (1) summary
    cl21455
    Location:8150
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  3. NM_181988.2NP_871788.1  ras-related and estrogen-regulated growth inhibitor isoform a

    See identical proteins and their annotated locations for NP_871788.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 each encode isoform a.
    Source sequence(s)
    AC122303, AC144767, AK133734
    Consensus CDS
    CCDS20663.1
    UniProtKB/Swiss-Prot
    Q8R367
    Related
    ENSMUSP00000032347.5, ENSMUST00000032347.11
    Conserved Domains (1) summary
    cd04146
    Location:8169
    RERG_RasL11_like; Ras-related and Estrogen-Regulated Growth inhibitor (RERG) and Ras-like 11 (RasL11)-like families

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    137031822..137147494 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036166088.1XP_036021981.1  ras-related and estrogen-regulated growth inhibitor isoform X1

    Conserved Domains (1) summary
    cl38936
    Location:1114
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
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