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ZC3H7B zinc finger CCCH-type containing 7B [ Homo sapiens (human) ]

Gene ID: 23264, updated on 4-Jul-2021

Summary

Official Symbol
ZC3H7Bprovided by HGNC
Official Full Name
zinc finger CCCH-type containing 7Bprovided by HGNC
Primary source
HGNC:HGNC:30869
See related
Ensembl:ENSG00000100403 MIM:618206
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RoXaN; ROXAN1
Summary
This gene encodes a protein that contains a tetratricopeptide repeat domain. The encoded protein also interacts with the rotavirus non-structural protein NSP3. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in kidney (RPKM 25.2), ovary (RPKM 25.2) and 25 other tissues See more
Orthologs
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Genomic context

See ZC3H7B in Genome Data Viewer
Location:
22q13.2
Exon count:
23
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (41301525..41360147)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (41697529..41756151)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene Ran GTPase activating protein 1 Neighboring gene microRNA 6889 Neighboring gene Sharpr-MPRA regulatory region 14092 Neighboring gene uncharacterized LOC100996598 Neighboring gene uncharacterized LOC105373042 Neighboring gene RNA, U6 small nuclear 495, pseudogene Neighboring gene TEF transcription factor, PAR bZIP family member

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of zinc finger CCCH-type containing 7B (ZC3H7B) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13787, KIAA1031, DKFZp434K0920

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables miRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables miRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
zinc finger CCCH domain-containing protein 7B
Names
Rotavirus 'X' associated non-structural protein
rotavirus 'X'-associated non-structural protein
rotavirus X protein associated with NSP3
ubiquitous tetratricopeptide containing protein RoXaN

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017590.6NP_060060.3  zinc finger CCCH domain-containing protein 7B

    See identical proteins and their annotated locations for NP_060060.3

    Status: REVIEWED

    Source sequence(s)
    AL035659
    Consensus CDS
    CCDS14013.1
    UniProtKB/Swiss-Prot
    Q9UGR2
    Related
    ENSP00000345793.4, ENST00000352645.5
    Conserved Domains (6) summary
    sd00020
    Location:844866
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00006
    Location:3964
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:83112
    TPR_1; Tetratricopeptide repeat
    pfam00642
    Location:890913
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam12171
    Location:844867
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    pfam13414
    Location:37112
    TPR_11; TPR repeat

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    41301525..41360147
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011530016.3XP_011528318.1  zinc finger CCCH domain-containing protein 7B isoform X1

    See identical proteins and their annotated locations for XP_011528318.1

    UniProtKB/TrEMBL
    A0A024R1N2
    Conserved Domains (3) summary
    sd00020
    Location:488510
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00642
    Location:534557
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    cl26464
    Location:6160
    Atrophin-1; Atrophin-1 family
  2. XM_024452182.1XP_024307950.1  zinc finger CCCH domain-containing protein 7B isoform X1

    Conserved Domains (3) summary
    sd00020
    Location:488510
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00642
    Location:534557
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    cl26464
    Location:6160
    Atrophin-1; Atrophin-1 family
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