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Hnrnpul1 heterogeneous nuclear ribonucleoprotein U-like 1 [ Mus musculus (house mouse) ]

Gene ID: 232989, updated on 11-Apr-2024

Summary

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Official Symbol
Hnrnpul1provided by MGI
Official Full Name
heterogeneous nuclear ribonucleoprotein U-like 1provided by MGI
Primary source
MGI:MGI:2443517
See related
Ensembl:ENSMUSG00000040725 AllianceGenome:MGI:2443517
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
E1BAP5; E1B-AP5; Hnrnpul; Hnrpul1; E130317O14Rik
Summary
Predicted to enable RNA binding activity and enzyme binding activity. Predicted to be involved in RNA processing and response to virus. Predicted to be located in nucleus. Predicted to be active in nucleoplasm. Orthologous to human HNRNPUL1 (heterogeneous nuclear ribonucleoprotein U like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 34.0), testis adult (RPKM 32.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 A3; 7 14.0 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (25420586..25455695, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (25721161..25756268, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene transforming growth factor, beta 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:26503991-26504174 Neighboring gene coiled-coil domain containing 97 Neighboring gene STARR-seq mESC enhancer starr_18313 Neighboring gene AXL receptor tyrosine kinase Neighboring gene predicted gene, 29763 Neighboring gene cytochrome P450, family 2, subfamily s, polypeptide 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Dynamics of alternative splicing during somatic cell reprogramming reveals functions for RNA-binding proteins CPSF3, hnRNP UL1, and TIA1. Vivori C, et al. Genome Biol, 2021 Jun 3. PMID 34082786, Free PMC Article
  2. Identification of differential protein interactors of lamin A and progerin. Kubben N, et al. Nucleus, 2010 Nov-Dec. PMID 21327095, Free PMC Article
  3. In-depth protein profiling of the postsynaptic density from mouse hippocampus using data-independent acquisition proteomics. Distler U, et al. Proteomics, 2014 Nov. PMID 25211037
  4. The ATG5 interactome links clathrin-mediated vesicular trafficking with the autophagosome assembly machinery. Baines K, et al. Autophagy Rep, 2022. PMID 35449600, Free PMC Article
  5. Interactome of vertebrate GAF/ThPOK reveals its diverse functions in gene regulation and DNA repair. Srivastava A, et al. J Biosci, 2020. PMID 32098917

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dynamics of alternative splicing during somatic cell reprogramming reveals functions for RNA-binding proteins CPSF3, hnRNP UL1, and TIA1.
    Title: Dynamics of alternative splicing during somatic cell reprogramming reveals functions for RNA-binding proteins CPSF3, hnRNP UL1, and TIA1.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC36621, MGC78330

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in alternative mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in synapse EXP
Inferred from Experiment
more info
 PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
heterogeneous nuclear ribonucleoprotein U-like protein 1
Names
EIB-55kDa associated protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360789.1 → NP_001347718.1  heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 3, which has a shorer N-terminus, compared to isoform 1.
    Source sequence(s)
    AK087545, AK143666, AK155604, BY482198, CD804713
    Consensus CDS
    CCDS90188.1
    Related
    ENSMUSP00000037268.9, ENSMUST00000043765.14
    Conserved Domains (2) summary
    cd12884
    Location:112 → 289
    SPRY_hnRNP; SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1
    pfam13671
    Location:324 → 469
    AAA_33; AAA domain

  2. NM_144922.3 → NP_659171.1  heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform 1

    See identical proteins and their annotated locations for NP_659171.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK087545, AK143666, AK155604, BY482198, CD804713
    Consensus CDS
    CCDS20995.1
    UniProtKB/Swiss-Prot
    Q3U201, Q3UPB0, Q6AZA7, Q8BY45, Q8K365, Q8VDM6
    Related
    ENSMUSP00000146263.2, ENSMUST00000206832.2
    Conserved Domains (4) summary
    smart00513
    Location:3 → 37
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam13671
    Location:424 → 569
    AAA_33; AAA domain
    cd12884
    Location:212 → 389
    SPRY_hnRNP; SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1
    cl17190
    Location:424 → 562
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

  3. NM_178089.3 → NP_835190.1  heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform 2

    See identical proteins and their annotated locations for NP_835190.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks several exons and contains an alternale 3' terminal exon, resulting in novel 3' coding region, compared to variant 1. It encodes isoform 2, which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK042090, AK143666, AK155604, AW494828
    Consensus CDS
    CCDS39841.1
    UniProtKB/Swiss-Prot
    Q8VDM6
    Related
    ENSMUSP00000104038.2, ENSMUST00000108401.3
    Conserved Domains (2) summary
    smart00513
    Location:3 → 37
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    cd12884
    Location:212 → 337
    SPRY_hnRNP; SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    25420586..25455695 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006539856.4 → XP_006539919.1  heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006539919.1

    UniProtKB/Swiss-Prot
    Q8VDM6
    Conserved Domains (2) summary
    cd12884
    Location:112 → 289
    SPRY_hnRNP; SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1
    pfam13671
    Location:324 → 469
    AAA_33; AAA domain

  2. XM_036152949.1 → XP_036008842.1  heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform X1

    Conserved Domains (2) summary
    cd12884
    Location:112 → 289
    SPRY_hnRNP; SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1
    pfam13671
    Location:324 → 469
    AAA_33; AAA domain

  3. XM_036152950.1 → XP_036008843.1  heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform X2

    Conserved Domains (1) summary
    pfam13671
    Location:1 → 144
    AAA_33; AAA domain

RNA

  1. XR_004934071.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VDM6.1 GenPept UniProtKB/Swiss-Prot:Q8VDM6

Gene LinkOut

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