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Mybpc2 myosin binding protein C, fast-type [ Mus musculus (house mouse) ]

Gene ID: 233199, updated on 21-Apr-2024

Summary

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Official Symbol
Mybpc2provided by MGI
Official Full Name
myosin binding protein C, fast-typeprovided by MGI
Primary source
MGI:MGI:1336170
See related
Ensembl:ENSMUSG00000038670 AllianceGenome:MGI:1336170
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to be a structural constituent of cytoskeleton. Acts upstream of or within muscle contraction. Predicted to be located in cytoskeleton. Is expressed in diaphragm; extensor digitorum longus; hindlimb; rectus femoris; and soleus. Orthologous to human MYBPC2 (myosin binding protein C2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in mammary gland adult (RPKM 39.2) and heart adult (RPKM 2.0) See more
Orthologs
human all
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Genomic context

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Location:
7 B3; 7 28.83 cM
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (44151123..44174093, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (44501699..44524715, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 5430431A17 gene Neighboring gene STARR-seq mESC enhancer starr_18800 Neighboring gene ER membrane protein complex subunit 10 Neighboring gene golgi associated RAB2 interactor 5A Neighboring gene STARR-positive B cell enhancer ABC_E10437 Neighboring gene Spi-B transcription factor (Spi-1/PU.1 related) Neighboring gene polymerase (DNA directed), delta 1, catalytic subunit Neighboring gene microRNA 7053

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Fast skeletal myosin-binding protein-C regulates fast skeletal muscle contraction. Song T, et al. Proc Natl Acad Sci U S A, 2021 Apr 27. PMID 33888578, Free PMC Article
  2. Cleavage of poly(ADP-ribose) polymerase: a sensitive parameter to study cell death. Duriez PJ, et al. Biochem Cell Biol, 1997. PMID 9493956
  3. Fast and slow skeletal myosin binding protein-C and aging. Perazza LR, et al. Geroscience, 2023 Apr. PMID 36409445, Free PMC Article
  4. Differential expression of C-protein isoforms in developing and degenerating mouse striated muscles. Kurasawa M, et al. Muscle Nerve, 1999 Feb. PMID 10024132
  5. Isoform transitions of the myosin binding protein C family in developing human and mouse muscles: lack of isoform transcomplementation in cardiac muscle. Gautel M, et al. Circ Res, 1998 Jan 9-23. PMID 9440711

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Fast and slow skeletal myosin binding protein-C and aging.
    Title: Fast and slow skeletal myosin binding protein-C and aging.
  2. Fast skeletal myosin-binding protein-C regulates fast skeletal muscle contraction.
    Title: Fast skeletal myosin-binding protein-C regulates fast skeletal muscle contraction.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC28149

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of cytoskeleton TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cytoskeleton organization TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within muscle contraction TAS
Traceable Author Statement
more info
 PubMed 
involved_in sarcomere organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in M band IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoskeleton TAS
Traceable Author Statement
more info
 PubMed 
located_in myosin filament IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
myosin-binding protein C, fast-type
Names
fast MyBP-C
fast-type C-protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_146189.3 → NP_666301.2  myosin-binding protein C, fast-type

    See identical proteins and their annotated locations for NP_666301.2

    Status: VALIDATED

    Source sequence(s)
    AK029282, AK132563, CK787764
    Consensus CDS
    CCDS52233.1
    UniProtKB/Swiss-Prot
    Q5XKE0, Q8C109, Q8K2V0
    Related
    ENSMUSP00000130127.3, ENSMUST00000165208.4
    Conserved Domains (7) summary
    cd00096
    Location:1062 → 1127
    Ig; Immunoglobulin domain
    cd05748
    Location:853 → 924
    Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins
    cd05894
    Location:545 → 630
    Ig_C5_MyBP-C; C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C)
    smart00410
    Location:548 → 630
    IG_like; Immunoglobulin like
    cd00063
    Location:634 → 720
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:1043 → 1132
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:278 → 325
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    44151123..44174093 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5XKE0.1 GenPept UniProtKB/Swiss-Prot:Q5XKE0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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