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Mrgprb1 MAS-related GPR, member B1 [ Mus musculus (house mouse) ]

Gene ID: 233231, updated on 11-Apr-2024

Summary

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Official Symbol
Mrgprb1provided by MGI
Official Full Name
MAS-related GPR, member B1provided by MGI
Primary source
MGI:MGI:3033115
See related
Ensembl:ENSMUSG00000070547 AllianceGenome:MGI:3033115
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MrgB1
Summary
Predicted to enable G protein-coupled receptor activity and neuropeptide binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway; mast cell degranulation; and positive regulation of cytokinesis. Predicted to act upstream of or within signal transduction. Predicted to be located in membrane. Predicted to be integral component of membrane. Orthologous to human MRGPRX2 (MAS related GPR family member X2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
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Genomic context

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See Mrgprb1 in Genome Data Viewer
Location:
7 B4; 7 31.11 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (48093861..48106090, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (48444113..48456342, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene MAS-related GPR, member B8 Neighboring gene DNA-directed RNA polymerases I, II, and III subunit RPABC4 pseudogene Neighboring gene STARR-seq mESC enhancer starr_18883 Neighboring gene STARR-seq mESC enhancer starr_18884 Neighboring gene MAS-related GPR, member X2 Neighboring gene STARR-seq mESC enhancer starr_18885 Neighboring gene MAS-related GPR, member B2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Orphan G protein-coupled receptors MrgA1 and MrgC11 are distinctively activated by RF-amide-related peptides through the Galpha q/11 pathway. Han SK, et al. Proc Natl Acad Sci U S A, 2002 Nov 12. PMID 12397184, Free PMC Article
  2. A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. Dong X, et al. Cell, 2001 Sep 7. PMID 11551509
  3. Atypical expansion in mice of the sensory neuron-specific Mrg G protein-coupled receptor family. Zylka MJ, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12909716, Free PMC Article
  4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables neuropeptide binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mast cell activation ISO
Inferred from Sequence Orthology
more info
  
involved_in mast cell degranulation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cytokinesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
mas-related G-protein coupled receptor member B1
Names
MrgB1 G protein-coupled receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_205810.4 → NP_991379.3  mas-related G-protein coupled receptor member B1

    See identical proteins and their annotated locations for NP_991379.3

    Status: VALIDATED

    Source sequence(s)
    AK148114, AK148279
    Consensus CDS
    CCDS52257.1
    UniProtKB/Swiss-Prot
    A4FUT5, A4QMY7, Q3UFN5, Q3UFT1, Q3UFW7, Q3UFX0, Q3UFX7, Q3UFY5, Q3UG23, Q3UG61, Q3UG95, Q91ZC3
    UniProtKB/TrEMBL
    W8W3M3
    Related
    ENSMUSP00000091946.4, ENSMUST00000094384.4
    Conserved Domains (1) summary
    cd15107
    Location:43 → 318
    7tmA_MrgprB; mas-related G protein-coupled receptor subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    48093861..48106090 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UG61.1 GenPept UniProtKB/Swiss-Prot:Q3UG61

Gene LinkOut

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