Format

Send to:

Choose Destination

Prc1 protein regulator of cytokinesis 1 [ Mus musculus (house mouse) ]

Gene ID: 233406, updated on 26-Jul-2021

Summary

Official Symbol
Prc1provided by MGI
Official Full Name
protein regulator of cytokinesis 1provided by MGI
Primary source
MGI:MGI:1858961
See related
Ensembl:ENSMUSG00000038943
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D7Ertd348; D7Ertd348e
Expression
Broad expression in CNS E11.5 (RPKM 31.2), liver E14 (RPKM 29.8) and 16 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Prc1 in Genome Data Viewer
Location:
7 D2; 7 45.62 cM
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (79944024..79966007)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (80294445..80316259)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (87439351..87461145)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene neugrin, neurite outgrowth associated Neighboring gene vacuolar protein sorting 33B Neighboring gene RCC1 domain containing 1 Neighboring gene unc-45 myosin chaperone A Neighboring gene HD domain containing 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Chemically induced (ENU) (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC6745

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables kinesin binding ISO
Inferred from Sequence Orthology
more info
 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cytokinesis ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within microtubule bundle formation ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitotic spindle midzone assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cytokinesis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in contractile ring ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in midbody ISO
Inferred from Sequence Orthology
more info
 
is_active_in mitotic spindle midzone IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in spindle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in spindle ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
protein regulator of cytokinesis 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001285997.1NP_001272926.1  protein regulator of cytokinesis 1 isoform 2

    See identical proteins and their annotated locations for NP_001272926.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple differences in the coding region but maintains the reading frame, compared to variant 4. This variant encodes isoform 2, which is shorter than isoform 4.
    Source sequence(s)
    AC136740, BC059808, CF736005
    Consensus CDS
    CCDS71985.1
    UniProtKB/Swiss-Prot
    Q99K43
    Related
    ENSMUSP00000043379.8, ENSMUST00000047558.14
    Conserved Domains (2) summary
    pfam03999
    Location:37598
    MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
    pfam13094
    Location:34130
    CENP-Q; CENP-Q, a CENPA-CAD centromere complex subunit
  2. NM_001285998.1NP_001272927.1  protein regulator of cytokinesis 1 isoform 3

    See identical proteins and their annotated locations for NP_001272927.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has multiple differences in the coding region but maintains the reading frame, compared to variant 4. This variant encodes isoform 3, which is shorter than isoform 4.
    Source sequence(s)
    AC136740, BC059808, CF736005
    Consensus CDS
    CCDS71986.1
    UniProtKB/TrEMBL
    G3UY19
    Related
    ENSMUSP00000133910.2, ENSMUST00000173824.8
    Conserved Domains (1) summary
    pfam03999
    Location:37560
    MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
  3. NM_001374624.1NP_001361553.1  protein regulator of cytokinesis 1 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) encodes the longest isoform (4).
    Source sequence(s)
    AC109232, AC136740
    Consensus CDS
    CCDS90258.1
    Related
    ENSMUSP00000133387.2, ENSMUST00000174172.8
    Conserved Domains (1) summary
    pfam03999
    Location:37615
    MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
  4. NM_001382385.1NP_001369314.1  protein regulator of cytokinesis 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC109232, AC136740
    Conserved Domains (1) summary
    pfam03999
    Location:37549
    MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
  5. NM_001382386.1NP_001369315.1  protein regulator of cytokinesis 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC109232, AC136740
    Conserved Domains (1) summary
    pfam03999
    Location:1496
    MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
  6. NM_001382387.1NP_001369316.1  protein regulator of cytokinesis 1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC109232, AC136740
    Conserved Domains (1) summary
    pfam03999
    Location:37517
    MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
  7. NM_001382388.1NP_001369317.1  protein regulator of cytokinesis 1 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC109232, AC136740
    Conserved Domains (1) summary
    pfam03999
    Location:37612
    MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
  8. NM_001382389.1NP_001369318.1  protein regulator of cytokinesis 1 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC109232, AC136740
    Conserved Domains (1) summary
    pfam03999
    Location:37614
    MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
  9. NM_001382390.1NP_001369319.1  protein regulator of cytokinesis 1 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC109232, AC136740
    Conserved Domains (1) summary
    pfam03999
    Location:1440
    MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
  10. NM_145150.3NP_660132.2  protein regulator of cytokinesis 1 isoform 1

    See identical proteins and their annotated locations for NP_660132.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) has multiple differences in the coding region but maintains the reading frame, compared to variant 4. This variant encodes isoform 1 which is shorter than isoform 4.
    Source sequence(s)
    AC136740, BC059808, CF736005
    Consensus CDS
    CCDS39998.2
    UniProtKB/TrEMBL
    G3UW86
    Related
    ENSMUSP00000129675.3, ENSMUST00000163812.9
    Conserved Domains (2) summary
    pfam03999
    Location:37601
    MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
    pfam13094
    Location:34130
    CENP-Q; CENP-Q, a CENPA-CAD centromere complex subunit

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    79944024..79966007
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006540855.5XP_006540918.1  protein regulator of cytokinesis 1 isoform X1

    Conserved Domains (1) summary
    pfam03999
    Location:37597
    MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
Support Center