Tufm Tu translation elongation factor, mitochondrial [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tufmprovided by MGI
Official Full Name: Tu translation elongation factor, mitochondrialprovided by MGI
Primary source: MGI:MGI:1923686
See related: Ensembl:ENSMUSG00000073838 AllianceGenome:MGI:1923686
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: EFTU; EF-TuMT; 2300002G02Rik
Summary: Predicted to enable translation elongation factor activity. Predicted to be involved in mitochondrial translational elongation. Predicted to act upstream of or within translation. Located in mitochondrial inner membrane and myelin sheath. Is expressed in embryo. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 4. Orthologous to human TUFM (Tu translation elongation factor, mitochondrial). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in adrenal adult (RPKM 104.1), heart adult (RPKM 88.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 F3; 7 69.08 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (126086445..126089903)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (126487271..126490731)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FUNDC1 protects against doxorubicin-induced cardiomyocyte PANoptosis through stabilizing mtDNA via interaction with TUFM.
Title: FUNDC1 protects against doxorubicin-induced cardiomyocyte PANoptosis through stabilizing mtDNA via interaction with TUFM.
TUFM is involved in Alzheimer's disease-like pathologies that are associated with ROS.
Title: TUFM is involved in Alzheimer's disease-like pathologies that are associated with ROS.
Activation of mitochondrial TUFM ameliorates metabolic dysregulation through coordinating autophagy induction.
Title: Activation of mitochondrial TUFM ameliorates metabolic dysregulation through coordinating autophagy induction.
Fancd2 localizes in the mitochondrion and associates with the nucleoid complex components Atad3 and Tufm.
Title: Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function.
By recruiting Atg5-Atg12 and NLRX1, TUFM serves as a nodal checkpoint of the RIG-I-MAVS axis. It acts similarly to NLRX1 by inhibiting RigI-like-receptor-induced IFN-I but promoting autophagy.
Title: The mitochondrial proteins NLRX1 and TUFM form a complex that regulates type I interferon and autophagy.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH126559 (e-PCR)
- UniSTS:209686

C76308 (e-PCR)
- UniSTS:179648

C76389 (e-PCR)
- UniSTS:159687

RH127594 (e-PCR)
- UniSTS:210904

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables translation elongation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables translation elongation factor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in mitochondrial translational elongation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within translation	IEA Inferred from Electronic Annotation more info
involved_in translational elongation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	HDA more info	PubMed
located_in mitochondrial nucleoid	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in myelin sheath	HDA more info	PubMed
is_active_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: elongation factor Tu, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001163713.1 → NP_001157185.1 elongation factor Tu, mitochondrial isoform 2

See identical proteins and their annotated locations for NP_001157185.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) includes an alternate segment that results in a frameshift compared to variant 1. The resulting protein (isoform 2) has a distinct C-terminus compared to isoform 1.

Source sequence(s)

AK152858, BC060959, BU699735, BY246546

Consensus CDS

CCDS52398.1

UniProtKB/Swiss-Prot

Q8BFR5

Related

ENSMUSP00000102000.4, ENSMUST00000106392.10

Conserved Domains (3) summary

cd01884
Location:56 → 250

EF_Tu; Elongation Factor Tu (EF-Tu) GTP-binding proteins

pfam00009
Location:55 → 248

GTP_EFTU; Elongation factor Tu GTP binding domain

cd03697
Location:258 → 344

EFTU_II; Domain II of elongation factor Tu
NM_172745.3 → NP_766333.1 elongation factor Tu, mitochondrial isoform 1

See identical proteins and their annotated locations for NP_766333.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AK152858, BC060959, BY246546

Consensus CDS

CCDS21830.1

UniProtKB/Swiss-Prot

Q497E7, Q6P919, Q8BFR5

Related

ENSMUSP00000095656.5, ENSMUST00000098048.6

Conserved Domains (4) summary

cd01884
Location:56 → 250

EF_Tu; Elongation Factor Tu (EF-Tu) GTP-binding proteins

PRK00049
Location:47 → 439

PRK00049; elongation factor Tu; Reviewed

cd03697
Location:258 → 344

EFTU_II; Domain II of elongation factor Tu

cd03706
Location:347 → 439

mtEFTU_III; Domain III of mitochondrial EF-TU (mtEF-TU)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

126086445..126089903

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006507719.5 → XP_006507782.1 elongation factor Tu, mitochondrial isoform X1

Conserved Domains (1) summary

PRK00049
Location:47 → 411

PRK00049; elongation factor Tu; Reviewed
XM_036153012.1 → XP_036008905.1 elongation factor Tu, mitochondrial isoform X2

Conserved Domains (1) summary

PRK00049
Location:1 → 303

PRK00049; elongation factor Tu; Reviewed